Job Description P37648 Confidence 100.00% Date Thu Jan 5 11:56:20 GMT 2012 Rank 6 Aligned Residues 415 % Identity 12% Template c2wk3A_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:insulin degrading enzyme; PDBTitle: crystal structure of human insulin-degrading enzyme in2 complex with amyloid-beta (1-42) Resolution 2.59 Å

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		26	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.		.	.	.	.	.	100	.	.	.	.
Predicted Secondary structure																																																																							.
Query SS confidence																																																																							.
Query Sequence		A	L	Q	P	D	P	A	W	Q	Q	G	T	L	S	N	G	L	Q	W	Q	V	L	T	T	P	Q	R	P	S	D	R	V	E	I	R	L	L	V	N	T	G	S	L	A	E	S	T	Q	Q	S	G	Y	S	H	A	I	P	R	I	A	L	T	Q	S	G	G	L	D	A	.	A	Q	A	R	S	L	W	Q	Q	G
Query Conservation																																																																							.
Alig confidence																															.	.																																							.										.
Template Conservation																															.	.																																																	.
Template Sequence		S	P	E	D	K	R	E	Y	R	G	L	E	L	A	N	G	I	K	V	L	L	I	S	D	P	T	T	D	K	.	.	S	S	A	A	L	D	V	H	I	G	S	L	S	D	P	P	N	I	A	G	L	S	H	F	L	Q	H	M	L	F	L	G	T	K	K	Y	P	K	E	N	E	Y	S	Q	F	L	S	E	.
Template Known Secondary structure			T	T											T	T										T	T		S		.	.								S			G	G	G	S		T	T	S	T	T									G	G	G		B	S	S	S		S	T	T									.
Template Predicted Secondary structure																															.	.																																																	.
Template SS confidence
		57	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.			.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.
		105	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.
Predicted Secondary structure																																																																															.	.	.
Query SS confidence																																																																															.	.	.
Query Sequence		I	D	P	K	R	P	M	P	P	V	I	V	S	Y	D	T	T	L	F	N	L	S	L	P	N	N	R	N	D	L	L	K	E	A	L	S	Y	L	A	N	A	T	G	K	L	T	I	T	P	E	T	I	N	H	A	L	Q	S	Q	D	M	V	A	T	W	P	A	D	T	K	E	G	W	W	R	Y	R	.	.	.
Query Conservation																																																																															.	.	.
Alig confidence		.	.	.																						.	.	.																																																			.	.	.
Template Conservation		.	.	.																						.	.	.
Template Sequence		.	.	.	H	A	G	S	S	N	A	F	T	S	G	E	H	T	N	Y	Y	F	D	V	S	.	.	.	H	E	H	L	E	G	A	L	D	R	F	A	Q	F	F	L	S	P	L	F	D	E	S	A	K	D	R	E	V	N	A	V	D	S	E	H	E	K	N	V	M	N	D	A	W	R	L	F	Q	L	E	K	A
Template Known Secondary structure		.	.	.	T	T									S	S										.	.	.	G	G	G										G	G	G	T		B																						T	T
Template Predicted Secondary structure		.	.	.																						.	.	.
Template SS confidence
					134	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.				.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.
			182	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.										200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.
Predicted Secondary structure		.																			.	.	.	.	.	.	.	.	.
Query SS confidence		.																			.	.	.	.	.	.	.	.	.
Query Sequence		.	L	K	G	S	T	L	L	G	H	D	P	A	D	P	L	K	Q	P	.	.	.	.	.	.	.	.	.	V	E	A	E	K	I	K	D	F	Y	Q	K	W	Y	T	P	D	A	M	T	L	L	V	V	G	N	V	D	A	R	S	V	V	D	Q	I	N	K	T	F	G	E	L	K	G	K	R	E	T	P	A	P
Query Conservation		.																			.	.	.	.	.	.	.	.	.
Alig confidence		.																			.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		T	G	N	P	K	H	P	F	S	K	F	G	T	G	N	K	Y	T	L	E	T	R	P	N	Q	E	G	I	D	V	R	Q	E	L	L	K	F	H	S	A	Y	Y	S	S	N	L	M	A	V	V	V	L	G	R	E	S	L	D	D	L	T	N	L	V	V	K	L	F	S	E	V	E	N	K	N	V	P	L	P	E
Template Known Secondary structure		T	S		T	T	S	G	G	G	S			S							T						T	T																	G	G	G								S	S														T	T	S
Template Predicted Secondary structure
Template SS confidence
		208	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.
		252	.	.	.	.			.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.
Predicted Secondary structure							.	.
Query SS confidence							.	.
Query Sequence		V	P	T	L	S	.	.	P	L	R	A	E	A	V	S	I	M	T	D	A	V	R	Q	D	R	L	S	I	M	W	D	T	P	W	Q	P	I	R	E	S	A	A	L	L	R	Y	W	R	A	D	L	A	R	E	A	L	F	W	H	V	Q	Q	A	L	S	A	S	N	S	K	D	I	G	L	G	F	D	C	R	V
Query Conservation							.	.
Alig confidence							.	.																																	.
Template Conservation																																									.
Template Sequence		F	P	E	H	P	F	Q	E	E	H	L	K	Q	L	Y	K	I	V	P	I	K	D	I	R	N	L	Y	V	T	F	P	I	P	D	L	Q	K	Y	Y	.	K	S	N	P	G	H	Y	L	G	H	L	I	G	H	E	G	P	G	S	L	L	S	E	L	K	S	K	G	W	V	N	T	L	V	G	G	Q	K	E	G
Template Known Secondary structure				S		S			G	G	G	S	S								S	S	S														G	G	G	T	.	T	T											T			S	T	T									T	T	S		S
Template Predicted Secondary structure																																									.
Template SS confidence
		288	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.		.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.
		330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.				.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.
Predicted Secondary structure																		.	.	.
Query SS confidence																		.	.	.
Query Sequence		L	Y	L	R	A	Q	C	A	I	N	I	E	S	P	N	D	.	.	.	K	L	N	S	N	L	N	L	V	A	R	E	L	A	K	V	R	D	K	G	L	P	E	E	E	F	N	A	L	V	A	Q	K	K	L	E	L	Q	K	L	F	A	A	Y	A	R	A	D	T	D	I	L	M	G	Q	R	M	R	S	L	Q
Query Conservation																		.	.	.
Alig confidence																		.	.	.																																																									.	.	.	.	.
Template Conservation																																																																													.	.	.	.	.
Template Sequence		A	R	G	F	M	F	F	I	I	N	V	D	L	T	E	E	G	L	L	H	V	E	D	I	I	L	H	M	F	Q	Y	I	Q	K	L	R	A	E	G	P	Q	E	W	V	F	Q	E	L	K	D	L	N	A	V	A	F	R	F	K	D	K	E	R	P	R	G	Y	T	S	K	I	A	G	I	L	.	.	.	.	.
Template Known Secondary structure			T	T																T	T																																						T																	T	.	.	.	.	.
Template Predicted Secondary structure																																																																													.	.	.	.	.
Template SS confidence
		367	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.
		407	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	Q	V	V	D	I	A	P	E	Q	Y	Q	K	L	R	Q	D	F	L	N	S	L	T	V	E	M	L	N	Q	D	L	R	Q	Q	L	S	N	D	M	A	L	I	L	L	Q	P	K	G	E	P	E	F	N
Query Conservation
Alig confidence		.	.	.	.
Template Conservation		.	.	.	.
Template Sequence		.	.	.	.	H	Y	Y	P	L	E	E	V	L	T	A	E	Y	L	L	E	E	F	R	P	D	L	I	E	M	V	L	D	K	L	R	P	E	N	V	R	V	A	I	V	S	K	S	F	E	G	K	T	D
Template Known Secondary structure		.	.	.	.	T	T	S		G	G	G	T	T	T	T	T	T															T	T		S	G	G	G								G	G	G	T	T
Template Predicted Secondary structure		.	.	.	.
Template SS confidence
						442	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490