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Job DescriptionQ46814
Confidence100.00%DateThu Jan 5 12:34:41 GMT 2012
Rank1Aligned Residues880
% Identity27%Templatec1wygA_
PDB info PDB header:oxidoreductaseChain: A: PDB Molecule:xanthine dehydrogenase/oxidase; PDBTitle: crystal structure of a rat xanthine dehydrogenase triple mutant2 (c535a, c992r and c1324s)
Resolution2.60 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   3......10.... .....20........ .30.........40.........50.. .......60.........70
Predicted Secondary structure 

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Query Sequence  IHFTLNGAPQEL. TVNPGENVQKLLFN. MGMHSVRNSDDGFGFAGSDAIIFN. . . . . . . . . . GNIVNASLLIAAQLEKAD
Query Conservation    
 


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Template Conservation 
 
  

  
      
  


  

    




 

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Template Sequence  LVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGC. GEGGCGACTVMISKYDRLQNKIVHFSVNACLAPICSLHHVA
Template Known Secondary structure  TTSS

TT
BSS


SS

S
.SSSSS
TTTTTTTTT
BGGG
TT
Template Predicted Secondary structure 




















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   6...10.........20.........30.........40... ......50.........60.........70.........80....
 
   71........80.........90.........100.........110.........120.........130.........140.........150
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Query Sequence  IRTAESLGKWNELSLVQQAMVDVGVVQSGYNDPAAALIITDLLDRIAAPTREEIDDALSGLFSRDAGWQQYYQVIELAVA
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Template Conservation 
 





    




   
  










 







     

   
  

 














    
 
Template Sequence  VTTVEGIGNTQKLHPVQERIARSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAK
Template Known Secondary structure 
GGGT

SSS

TT

SS
SS
SS

GGG


SSS
STT

Template Predicted Secondary structure 




































Template SS confidence 















































































   85....90.........100.........110.........120.........130.........140.........150.........160....
 
   151......
Predicted Secondary structure 






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Query SS confidence 






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Query Sequence  RKNNPQA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation         .........................................................................
Alig confidence 






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Template Conservation                      
                         
 

 

  

   
 
 









      
Template Sequence  PSLFNPEDFKPLDPTQEPIFPPELLRLKDTPQKKLRFEGERVTWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKN
Template Known Secondary structure 

S

GGGS



GGGS



TTS




SS


S
TT

SS
TTS
Template Predicted Secondary structure 











































Template SS confidence 















































































   192.......200.........210.........220.........230.........240.........250.........260.........270.
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
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Template Sequence  MLFPLIVCPAWIPELNSVVHGPEGISFGASCPLSLVESVLAEEIAKLPEQKTEVFRGVMEQLRWFAGKQVKSVASIGGNI
Template Known Secondary structure 


S
TT
SGGG

SSTT
BS
TTT
TTSS
TT
B
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   272.......280.........290.........300.........310.........320.........330.........340.........350.
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation    


 

  
 
 

 
 
 
 
  
 
 
   
 

 
   
 
   


  
 

           
   
   


Template Sequence  ITASPISDLNPVFMASGAKLTLVSRGTRRTVRMDHTFFPGYRKTLLRPEEILLSIEIPYSKEGEFFSAFKQASRREDDIA
Template Known Secondary structure 

TT
SSTTT

SS

STTT

STT

S

TT



TT
S
SSS


Template Predicted Secondary structure 







































Template SS confidence 















































































   352.......360.........370.........380.........390.........400.........410.........420.........430.
 
  
Predicted Secondary structure  ................................................................................
Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation   
 

  
 
      
   


 



  
 

   
  
 
       
  
   
  
  
  
    
 


  

Template Sequence  KVTSGMRVLFKPGTIEVQELSLCFGGMADRTISALKTTPKQLSKSWNEELLQSVCAGLAEELQLAPDAPGGMVEFRRTLT
Template Known Secondary structure  S
TTS
BSSSSS

TTTTGGGTT
BSST


TT
TT

Template Predicted Secondary structure 



























Template SS confidence 















































































   432.......440.........450.........460.........470.........480.........490.........500.........510.
 
   158.160.........170.........180.........190
Predicted Secondary structure  ...............................................




























Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
































Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . TIDIAPTFRDDLEVIGKHYPKTDAAKMVQAKPC
Query Conservation  ...............................................              

    
 
    


   
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Template Conservation    

 

 
 
                                   
              



  
     



 
 
Template Sequence  LSFFFKFYLTVLQKLGRADLEDMAGKLDPTFASATLLFQKDPPANVQLFQEVPKDQSEEDMVGRPLPHLAANMQASGEAV
Template Known Secondary structure  TTTT



TTTSGGG














SSS
TT

TTS



TTT
S
Template Predicted Secondary structure 






















































Template SS confidence 















































































   512.......520.........530.........540.........550.........560.........570.........580.........590.
 
   191.... ....200.........210.........220.........230.........240.........250.........260.........
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Query Sequence  YVEDR. VTADACVIKMLRSPHAHALITHLDVSKAEALPGVVHVITHLNCPDIYYTPGGQSAPEPSPLDRRMFGKKMRHVG
Query Conservation 
  
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Template Conservation 
 


    
 
 
  



 


 
 


 
 
   


  
 
  


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Template Sequence  YCDDIPRYENELSLRLVTSTRAHAKITSIDTSEAKKVPGFVCFLTAEDVPNSNATGLFN. . . . . . . DETVFAKDEVTCVG
Template Known Secondary structure 
GGGS


SS

SSSS
TTGGGSTT
STT
SS

STTS.......
SS

S
STT
Template Predicted Secondary structure 





























.......






Template SS confidence 















































































   592.......600.........610.........620.........630.........640.........650 .........660....
 
   270.........280.........290.........300.........310.........320.........330.........340.........
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Query Sequence  DRVAAVVAESEEIALEALKLIDVEYEVLKPVMSIDEAMAEDAPVVHDEPVVYVAGAPDTLEDDNSHAAQRGEHMIINFPI
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Template Sequence  HIIGAVVADTPEHAQRAARGVKITYEDLPAIITIQDAINNNSFYGSEIK. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure 
SSTT







ST
BSSS
...............................
Template Predicted Secondary structure 























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Template SS confidence 















































































   665....670.........680.........690.........700.........710...
 
   350.........360.........370.........380.........390.........400.. .......410.........420.......
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Query Sequence  GSRPRKNIAASIHGHIGDMDKGFADADVIIERTYNSTQAQQCPTETHICFTRM. . DGDRLVIHASTQVPWHLRRQVARLV
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Template Conservation  .............   

    
  
  


       
 
  


   

      
 
 
  


 
   
  

  
Template Sequence  . . . . . . . . . . . . . IEKGDLKKGFSEADNVVSGELYIGGQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKML
Template Known Secondary structure  .............S
T
S

B



SS


SSTT


S
Template Predicted Secondary structure  .............























Template SS confidence 















































































   714.....720.........730.........740.........750.........760.........770.........780
 
   428.430.........440.........450.. .......460.........470.........480.........490.........500.....
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Query Sequence  GMKQHKVHVIKERVGGGFGSKQDIL. . LEEVCAWATCVTGRPVLFRYTREEEFIANTSRHVAKVTVKLGAKKDGRLTAVK
Query Conservation 


   
 
    







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Template Conservation 


   


    





 
          




   




   

 
 
     
       


   

 
 

 
Template Sequence  GVPDNRIVVRVKRMGGGFGGKETRSTVVSTALALAAHKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTVVALE
Template Known Secondary structure  T

GGGS

S

TTTTSSSTSS




B


TTS
Template Predicted Secondary structure 


































Template SS confidence 















































































   781........790.........800.........810.........820.........830.........840.........850.........860
 
   506...510.........520.........530.........540.........550.........560.........570.........580.....
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Query Sequence  MDFRANTGPYGNHSLTVPCNGPALSLPLYPCDNVDFQVTTYYSNICPNGAYQGYGAPKGNFAITMALAELAEQLQIDQLE
Query Conservation       
 

       
           
 


       
 

     
 

 
  
   
 
  

 

  

 

 
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Template Conservation       
 

       
         
 
 


       
 

     
 

 
 

  

 
  

 

  

 

 
Template Sequence  VAHFSNGGNTEDLSRSIMERALFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAITCGLPAEE
Template Known Secondary structure  SS
TTTTTTTTB

SS
SS





TTTTTS
Template Predicted Secondary structure 
































Template SS confidence 















































































   861........870.........880.........890.........900.........910.........920.........930.........940
 
   586...590.........600.........610.........620.........630....... ..640.........650.........660
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Query Sequence  IIERNRVHEGQELKILGAIGEGKAPTSVPSAASCALEEILRQGREMIQWSSP. . . . . KPQNGDWHIGRGVAIIMQKSGIP
Query Conservation 

  
    

                            
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Template Conservation   
  
    
     
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Template Sequence  VRRKNMYKEGDLTHFNQKLEGF. . . . . . . . . . . . TLPRCWDECIASSQYLARKREVEKFNRENRWKKRGLCIIPTKFGIS
Template Known Secondary structure  B

TT
B
TT

B

S
............
TS
SS
S
Template Predicted Secondary structure 
















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   941........950.........960.. .......970.........980.........990.........1000........
 
   661. .......670.........680.........690.........700.........710.........720.........730......
Predicted Secondary structure 

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Query Sequence  DI. . . . DQANCMIKLESDGTFIVHSGGADIGTGLDTVVTKLAAEVLHCPPQDVHVISGDTDHALFDKGAYASSGTCFSGN
Query Conservation    ....    
 
 
  



 
  
  
 


  
   



  



   
 
   

   
    
  
  
   
 
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Template Conservation            
 
 
  



 
  
  
 


  
  




  



   
 
   

   
    
 


 
   
 
Template Sequence  FTLPFLNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHISETSTNTVPNTSPTAASASADLNGQ
Template Known Secondary structure 
SSGGG

TTS
S


SSS
TTS
GGG

TTTS
S


S
TTT
Template Predicted Secondary structure 

































Template SS confidence 















































































   10091010.........1020.........1030.........1040.........1050.........1060.........1070.........1080........
 
   737..740.........750.........760.........770.........780.........790.........800.........810......
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Query Sequence  AARLAAENLREKILFHGAQMLGEPVADVQLATPGVVRGKKGEVSFGDIAHKGETGTGFGSLVGTGSYITPDFAFPYGANF
Query Conservation 

  
   
  

   

                                 
                 
      

  
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Template Conservation 

  

  
  

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Template Sequence  GVYEACQTILKRLEPFKKKKPTGPWEAW. . . . . . VMDAYTSAVSL. . . SATGFYKTPNLGYSFETNSGNPFHYFSYGVAC
Template Known Secondary structure  STTS
......TT


...
TT


BTTTTBS


S
Template Predicted Secondary structure 




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Template SS confidence 















































































   10891090.........1100.........1110...... ...1120....... ..1130.........1140.........1150.........
 
   817..820.........830.........840.........850.........860.........870.........880.........890......
Predicted Secondary structure 




































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Query Sequence  AEVAVNTRTGEIRLDKFYALLDCGTPVNPELALGQIYGATLRAIGHSMSEEIIYDAEGHPLTRDLRSYGAPKIGDIPRDF
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Template Conservation 





  

 
 
 
   
 
 
  


 
  





 




 

 

  

  
 
 
     
 

   


   
Template Sequence  SEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEF
Template Known Secondary structure 
TTTS
B


B
BS
S
T



B
TTS
B


STTTS



GGGS
SS
Template Predicted Secondary structure 



































Template SS confidence 















































































   1160.........1170.........1180.........1190.........1200.........1210.........1220.........1230.........
 
   897..900. ........910.........920..... ....930.... .....940.. .......950.....
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Query Sequence  RAVLV. PSDDKVGPFGAKSISEIGVNGAAP. . . AIATAIHDA. . . CGIWLREW. . . . . HFTPEKILTALEK
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Template Sequence  RVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDNAKQLFQLDSPATPEKIRNACVD
Template Known Secondary structure 
SS


TTTGGGB


SSGGGGGGTTSS

S
SS



BS

S
S
Template Predicted Secondary structure 









































Template SS confidence 






































































   1240.........1250.........1260.........1270.........1280.........1290.........1300.........1310
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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