Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	P	S	L	R	K	A	V	A	A	A	I	G	G	G	A	I	A	I	A	S	V	L	I	T	G	P	S	G	N	D	G	L	E	G	V	S	Y	I	P	Y	K	D	I	V	G	V	W	T	V	C	H	G	H	T	G	K	D	I
Secondary structure
SS confidence
Disorder		?	?											?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	L	G	K	T	Y	T	K	A	E	C	K	A	L	L	N	K	D	L	A	T	V	A	R	Q	I	N	P	Y	I	K	V	D	I	P	E	T	T	R	G	A	L	Y	S	F	V	Y	N	V	G	A	G	N	F	R	T	S	T	L	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.
Sequence		R	K	I	N	Q	G	D	I	K	G	A	C	D	Q	L	R	R	W	T	Y	A	G	G	K	Q	W	K	G	L	M	T	R	R	E	I	E	R	E	V	C	L	W	G	Q	Q
Secondary structure
SS confidence
Disorder																																											?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3hde chain A Region: 1 - 165 Aligned: 165 Modelled: 165 Confidence: 100.0% Identity: 99% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of full-length endolysin r21 from phage 21 Phyre2 PDB 1xjt chain A Region: 23 - 164 Aligned: 141 Modelled: 142 Confidence: 100.0% Identity: 27% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 3hdf chain A Region: 32 - 164 Aligned: 133 Modelled: 133 Confidence: 100.0% Identity: 98% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of truncated endolysin r21 from phage 21 Phyre2 PDB 2anx chain B Region: 20 - 162 Aligned: 142 Modelled: 143 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:lysozyme; PDBTitle: crystal structure of bacteriophage p22 lysozyme mutant l87m Phyre2 PDB 1xju chain A Region: 23 - 164 Aligned: 139 Modelled: 142 Confidence: 100.0% Identity: 29% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1lpy chain A Region: 27 - 164 Aligned: 133 Modelled: 138 Confidence: 100.0% Identity: 22% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 176l chain A Region: 26 - 164 Aligned: 132 Modelled: 139 Confidence: 100.0% Identity: 28% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1jtm chain A Region: 26 - 164 Aligned: 134 Modelled: 139 Confidence: 100.0% Identity: 24% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 169l chain A Region: 28 - 164 Aligned: 132 Modelled: 137 Confidence: 100.0% Identity: 25% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 191l chain A Region: 26 - 164 Aligned: 132 Modelled: 139 Confidence: 100.0% Identity: 26% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1p37 chain A Region: 27 - 164 Aligned: 133 Modelled: 138 Confidence: 100.0% Identity: 23% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1swy chain A Region: 27 - 164 Aligned: 131 Modelled: 138 Confidence: 100.0% Identity: 26% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1t8f chain A Region: 27 - 164 Aligned: 131 Modelled: 138 Confidence: 100.0% Identity: 26% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 157l chain A Region: 27 - 164 Aligned: 131 Modelled: 138 Confidence: 100.0% Identity: 24% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 146l chain A Region: 26 - 164 Aligned: 132 Modelled: 139 Confidence: 100.0% Identity: 24% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1l64 chain A Region: 27 - 164 Aligned: 131 Modelled: 138 Confidence: 100.0% Identity: 25% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 2f2q chain A domain 1 Region: 26 - 164 Aligned: 132 Modelled: 139 Confidence: 100.0% Identity: 27% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 189l chain A Region: 26 - 164 Aligned: 132 Modelled: 139 Confidence: 100.0% Identity: 27% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1k28 chain A domain 3 Region: 27 - 155 Aligned: 127 Modelled: 129 Confidence: 100.0% Identity: 28% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 2o4w chain A Region: 37 - 164 Aligned: 123 Modelled: 128 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: t4 lysozyme circular permutant Phyre2 1 c3hdeA_ 2 d1xjta_ 3 c3hdfA_ 4 c2anxB_ 5 d1xjua_ 6 d1lpya_ 7 d176la_ 8 d1jtma_ 9 d169la_ 10 d191la_ 11 d1p37a_ 12 d1swya_ 13 d1t8fa_ 14 d157la_ 15 d146la_ 16 d1l64a_ 17 d2f2qa1 18 d189la_ 19 d1k28a3 20 c2o4wA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3hdeA_ 100.0 99 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of full-length endolysin r21 from phage 21 2 d1xjta_ 100.0 27 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 3 c3hdfA_ 100.0 98 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of truncated endolysin r21 from phage 21 4 c2anxB_ 100.0 30 PDB header:hydrolase Chain: B: PDB Molecule:lysozyme; PDBTitle: crystal structure of bacteriophage p22 lysozyme mutant l87m 5 d1xjua_ 100.0 29 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 6 d1lpya_ 100.0 22 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 7 d176la_ 100.0 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 8 d1jtma_ 100.0 24 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 9 d169la_ 100.0 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 10 d191la_ 100.0 26 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 11 d1p37a_ 100.0 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 12 d1swya_ 100.0 26 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 13 d1t8fa_ 100.0 26 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 14 d157la_ 100.0 24 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 15 d146la_ 100.0 24 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 16 d1l64a_ 100.0 25 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 17 d2f2qa1 100.0 27 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 18 d189la_ 100.0 27 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 19 d1k28a3 100.0 28 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 20 c2o4wA_ 100.0 27 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: t4 lysozyme circular permutant 21 d1p5ca_ not modelled 100.0 27 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 22 c2qb0D_ not modelled 100.0 24 PDB header:hydrolase regulator Chain: D: PDB Molecule:telsam domain - lysozyme chimera; PDBTitle: structure of the 2tel crystallization module fused to t4 lysozyme with2 an ala-gly-pro linker. 23 c3sn6R_ not modelled 100.0 26 PDB header:signaling protein/hydrolase Chain: R: PDB Molecule:lysozyme, beta-2 adrenergic receptor; PDBTitle: crystal structure of the beta2 adrenergic receptor-gs protein complex 24 c1pdlC_ not modelled 99.9 26 PDB header:hydrolase Chain: C: PDB Molecule:tail-associated lysozyme; PDBTitle: fitting of gp5 in the cryoem reconstruction of the2 bacteriophage t4 baseplate 25 c2o7aA_ not modelled 99.8 26 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: t4 lysozyme c-terminal fragment 26 d2ikba1 not modelled 63.9 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:NMB1012-like 27 c2qvwA_ not modelled 59.8 14 PDB header:hydrolase Chain: A: PDB Molecule:glp_546_48378_50642; PDBTitle: structure of giardia dicer refined against twinned data 28 d2nr7a1 not modelled 36.8 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:NMB1012-like 29 d1a77a1 not modelled 13.5 16 Fold:SAM domain-like Superfamily:5' to 3' exonuclease, C-terminal subdomain Family:5' to 3' exonuclease, C-terminal subdomain 30 c3gabC_ not modelled 11.8 17 PDB header:hydrolase Chain: C: PDB Molecule:dna mismatch repair protein mutl; PDBTitle: c-terminal domain of bacillus subtilis mutl crystal form i 31 c2bvbA_ not modelled 10.3 40 PDB header:adhesion Chain: A: PDB Molecule:micronemal protein 1; PDBTitle: the c-terminal domain from micronemal protein 1 (mic1) from2 toxoplasma gondii 32 d2gboa1 not modelled 10.3 16 Fold:Open three-helical up-and-down bundle Superfamily:EF2458-like Family:EF2458-like 33 c2gboB_ not modelled 10.3 16 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:upf0358 protein ef2458; PDBTitle: protein of unknown function ef2458 from enterococcus faecalis 34 c2fmmE_ not modelled 9.8 13 PDB header:transcription Chain: E: PDB Molecule:protein emsy; PDBTitle: crystal structure of emsy-hp1 complex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0