Job Description P0AFI2 Confidence 100.00% Date Thu Jan 5 11:26:24 GMT 2012 Rank 11 Aligned Residues 446 % Identity 22% Template c3qx3B_ PDB info PDB header:isomerase/dna/isomerase inhibitor Chain: B: PDB Molecule:dna topoisomerase 2-beta; PDBTitle: human topoisomerase iibeta in complex with dna and etoposide Resolution 2.16 Å

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		3	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70			.	.	.	.	.	.	.	.	.	80
Predicted Secondary structure																																																																						.	.
Query SS confidence																																																																						.	.
Query Sequence		D	M	A	E	R	L	A	L	H	E	F	T	E	N	A	Y	L	N	Y	S	M	Y	V	I	M	D	R	A	L	P	F	I	G	D	G	L	K	P	V	Q	R	R	I	V	Y	A	M	S	E	L	G	L	N	A	S	A	K	F	K	K	S	A	R	T	V	G	D	V	.	.	L	G	K	Y	H	P	H	G	D	S
Query Conservation																																																																						.	.
Alig confidence																											.																											.	.	.														.	.						.
Template Conservation																											.																											.	.	.																					.
Template Sequence		H	G	T	K	H	L	T	Y	N	D	F	I	N	K	E	L	I	L	F	S	N	S	D	N	E	.	R	S	I	P	S	L	V	D	G	F	K	P	G	Q	R	K	V	L	F	T	C	F	K	R	N	D	.	.	.	K	R	E	V	K	V	A	Q	L	A	G	S	V	A	E	M	S	A	Y	H	.	H	G	E	Q
Template Known Secondary structure																T											.			S		B	T	T	T	S																		.	.	.	S	S																T			.	S
Template Predicted Secondary structure																											.																											.	.	.																					.
Template SS confidence
		694	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.		.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.				.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.		.	.	.	.
		81	.	.	.	.	.	.	.	.	90	.	.	.			.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110		.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.
Predicted Secondary structure															.	.																		.
Query SS confidence															.	.																		.
Query Sequence		A	C	Y	E	A	M	V	L	M	A	Q	P	F	.	.	S	Y	R	Y	P	L	V	D	G	Q	G	N	W	G	A	P	D	.	D	P	K	S	F	A	A	M	R	Y	T	E	S	R	L	S	K	Y	S	E	L	L	L	S	E	L	G	Q	G	T	A	D	W	V	P	N	F	D	G	T	L	Q	E	P	K	M	L
Query Conservation															.	.																		.
Alig confidence															.	.																		.																																					.
Template Conservation																																																																							.
Template Sequence		A	L	M	M	T	I	V	N	L	A	Q	N	F	V	G	S	N	N	I	N	L	L	Q	P	I	G	Q	F	G	T	R	L	H	G	G	K	D	A	A	S	P	R	Y	I	F	T	M	L	S	T	L	A	R	L	L	F	P	A	V	D	D	N	L	L	K	F	L	Y	D	.	D	N	Q	R	V	E	P	E	W	Y
Template Known Secondary structure														S	T	T	S		S	S		S	B			B	S					T	T	T	T	T	T	T				T	T	S					B		T	T					S		G	G	G	G	G	G	S						.	T	T						S
Template Predicted Secondary structure																																																																							.
Template SS confidence
		779	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.		.	.	850	.	.	.	.	.	.	.
		158	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	A	R	L	P	N	I	L	L	N	G	T	T	G	I	A	V	G	M	A	T	D	I	P	P	H	N	L	R	E	V	A	Q	A	A	I	A	L	I	D	Q	P	K	T	T	L	D	Q	L	L	D	I	V	Q	G	P	D	Y	P	T	E	A	E	I	I	T	S	R	A	E	I	R	K	I	Y	E	N	G	R	G
Query Conservation
Alig confidence																																																		.	.	.	.	.	.	.											.	.	.	.	.	.	.	.	.
Template Conservation																																																		.	.	.	.	.	.	.											.	.	.	.	.	.	.	.	.
Template Sequence		I	P	I	I	P	M	V	L	I	N	G	A	E	G	I	G	T	G	W	A	C	K	L	P	N	Y	D	A	R	E	I	V	N	N	V	R	R	M	L	D	G	L	D	P	H	P	M	L	.	.	.	.	.	.	.	P	N	Y	K	N	F	K	G	T	I	.	.	.	.	.	.	.	.	.	Q	E	L	G	Q	N
Template Known Secondary structure				S	S						T	T						S	S																						T	T								.	.	.	.	.	.	.				T	T			S			.	.	.	.	.	.	.	.	.					T	T
Template Predicted Secondary structure																																																		.	.	.	.	.	.	.											.	.	.	.	.	.	.	.	.
Template SS confidence
		858	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.								.	.	.	.	910	.	.	.	.	.										.	.	.	.	920	.
		238	.	240	.	.	.	.	.	.		.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.
Predicted Secondary structure											.
Query SS confidence											.
Query Sequence		S	V	R	M	R	A	V	W	K	.	K	E	D	G	A	V	V	I	S	A	L	P	H	Q	V	S	G	A	R	V	L	E	Q	I	A	A	Q	M	R	N	K	K	L	P	M	V	D	D	L	R	D	E	S	D	H	E	N	P	T	R	L	V	I	V	P	R	S	N	R	V	D	M	D	Q	V	M	N	H	L	F
Query Conservation											.
Alig confidence											.																																	.															.											.
Template Conservation																																												.															.											.
Template Sequence		Q	Y	A	V	S	G	E	I	F	V	V	D	R	N	T	V	E	I	T	E	L	P	V	R	T	W	T	Q	V	Y	K	E	Q	V	L	E	P	M	L	N	G	P	.	A	L	I	S	D	Y	K	E	Y	H	T	D	T	T	.	V	K	F	V	V	K	M	T	E	E	.	K	L	A	Q	A	E	A	A	G	L	H
Template Known Secondary structure														T	T									T	T										T									.				S								S	S		.											.								S
Template Predicted Secondary structure																																												.															.											.
Template SS confidence
		922	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.		.	.	.	.	.	.	970	.	.	.	.	.	.	.		.	.	980	.	.	.	.	.	.	.		.	.	990	.	.	.	.	.	.	.	.
		317	.	.	320	.	.	.	.	.	.	.		.	.	330	.	.	.	.	.	.	.	.	.	340	.		.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.		.	.	.	.	390	.	.	.
Predicted Secondary structure													.															.																																													.
Query SS confidence													.															.																																													.
Query Sequence		A	T	T	D	L	E	K	S	Y	R	I	.	N	L	N	M	I	G	L	D	G	R	P	A	V	K	.	N	L	L	E	I	L	S	E	W	L	V	F	R	R	D	T	V	R	R	R	L	N	Y	R	L	E	K	V	L	K	R	L	H	I	L	E	G	L	L	V	A	F	L	N	.	I	D	E	V	I	E	I	I
Query Conservation													.															.																																													.
Alig confidence													.															.																																													.
Template Conservation
Template Sequence		K	V	F	K	L	Q	T	T	L	T	C	N	S	M	V	L	F	D	H	M	G	C	L	K	K	Y	E	T	V	Q	D	I	L	K	E	F	F	D	L	R	L	S	Y	Y	G	L	R	K	E	W	L	V	G	M	L	G	A	E	S	T	K	L	N	N	Q	A	R	F	I	L	E	K	I	Q	G	K	I	T	I	E
Template Known Secondary structure				T	T															T	T	S						S	S																																															T	S				T
Template Predicted Secondary structure
Template SS confidence
		1003	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.
		394	.	.	.	.			.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.										.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.
Predicted Secondary structure							.	.																	.	.	.	.	.	.	.	.	.																																														.	.	.
Query SS confidence							.	.																	.	.	.	.	.	.	.	.	.																																														.	.	.
Query Sequence		R	N	E	D	E	.	.	P	K	P	A	L	M	S	R	F	G	L	T	E	T	Q	A	.	.	.	.	.	.	.	.	.	E	A	I	L	E	L	K	L	R	H	L	A	K	L	E	E	M	K	I	R	G	E	Q	S	E	L	E	K	E	R	D	Q	L	Q	G	I	L	A	S	E	R	K	M	N	N	.	.	.
Query Conservation							.	.																	.	.	.	.	.	.	.	.	.																																														.	.	.
Alig confidence							.	.																	.	.	.	.	.	.	.	.	.																																				.	.									.	.	.
Template Conservation																																																																					.	.
Template Sequence		N	R	S	K	K	D	L	I	Q	M	L	V	Q	R	G	Y	E	S	D	P	V	K	A	W	K	E	A	Q	G	P	D	F	N	Y	I	L	N	M	S	L	W	S	L	T	K	E	K	V	E	E	L	I	K	Q	R	D	A	K	G	R	E	V	N	D	L	K	R	.	.	K	S	P	S	D	L	W	K	E	D	L
Template Known Secondary structure		T													T	T			S																			T	S		G	G	G	G	S																								.	.	S
Template Predicted Secondary structure																																																																					.	.
Template SS confidence
		1083	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140	.	.	.	.	.	.	.	.	.			1150	.	.	.	.	.	.	.	.	.	1160
			460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.
Predicted Secondary structure		.
Query SS confidence		.
Query Sequence		.	L	L	K	K	E	L	Q	A	D	A	Q	A	Y	G	D	D
Query Conservation		.
Alig confidence		.
Template Conservation
Template Sequence		A	A	F	V	E	E	L	D	K	V	E	S	Q	E	R	E	D
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		1185	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200	.