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Job DescriptionP76464
Confidence100.00%DateWed Jan 25 15:21:08 GMT 2012
Rank1Aligned Residues1209
% Identity14%Templatec3cu7A_
PDB info PDB header:immune systemChain: A: PDB Molecule:complement c5; PDBTitle: human complement component 5
Resolution3.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   264.....270.........280.........290.........300.........310.... .....320......
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Query Sequence  VSGKELLVWTAGKKQGEAKPGSEILWTDGLGVMTRGVTDDSGTLQLQHISP. . . . . . . . . . . . . . . . . ERSYILGKDAEG
Query Conservation        

 
  
 

 

 

 
       

    

  
 
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Template Conservation 
 
    
 
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Template Sequence  RVGASENIVIQVYGYTEAF. DATISIKSYP. . . DKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVV
Template Known Secondary structure  TT






S

B.
TT...S


B

B
TTTTT









SS





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   32.......40.........50 .........60 .........70.........80.........90.........100.......
 
   327..330.........340.........350.........360.........370.........380.........390.........400......
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Query Sequence  GVFVSENFFYESEIYNTRLYIFTDRPLYRAGDRVDVKVIGREFHDPLHSSPIVSAPAKLSVLDANGSLLQTVNVTLDARN
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Template Sequence  SKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLK. . . . . PAKRETVLTFIDPEGSEVDMVEEIDHIGI
Template Known Secondary structure  SS




SS
S
TT


TT
S.....




TTT




SSS
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   108.110.........120.........130.........140.........150... ......160.........170.........180..
 
   407..410.........420.........430. ........440.........450.........460... ......470.........480.
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Query Sequence  GGQGSFRLPENAVAGGYELRLAYRN. . . QVYSSSFRVANYIKPHFEIGLALAKKEFKTGE. . AVSGKLQLLYPDGEPVKN
Query Conservation       
 

  
  
 
 
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Template Conservation       
 

     
 
 
 
          
  
 






 


 
              


 
 
 
  
 

 
Template Sequence  ISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTE
Template Known Secondary structure 




SS


BSSS






SS

S
S
STTSS


TTT
S
Template Predicted Secondary structure 






























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   183......190.........200.........210.........220.........230.........240.........250.........260..
 
   482.......490.........500.........510.........520.........530.. .......540....... .
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Query Sequence  ARVQLSLRAQQLSMVGNDLRYAGRFPVSLEGSETVSDASGHVALNLPAADK. . . . . . . . . . . PSRYLLTVSASDGAA. . Y
Query Conservation    
   
                            

  
     

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Template Conservation    
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Template Sequence  ADVYITFGIREDLKDDQKEMMQTA. . . . . MQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFS
Template Known Secondary structure  S
SS
S

SS
.....
B


TTB

TTTTTTTTSS


STT

SSSS


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   263......270.........280...... ...290.........300.........310.........320.........330.......
 
   549550.........560.........570.........580.........590.........600... ......610.....
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Query Sequence  RVTTTKEILIERGLAHYSLSTAAQYSNSGESVVFRYAALESSKQVPVTYEWLRLE. . . . . . . . . . . . . DRTSHSGELPSG
Query Conservation   
  
  
 
        
         
                

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Template Conservation         
        
          

 
    
 
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Template Sequence  EEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVK. DSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDG
Template Known Secondary structure 



S
S

BS

S
SSS
.TT

B

S
TTS





SSS
Template Predicted Secondary structure 








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   338.340.........350.........360.........370...... ...380.........390.........400.........410......
 
   616...620.... .....630.........640 .........650.........660.........670.........680.........
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Query Sequence  GKSFTVNFA. KPGNYNLTLRDKDGLI. . . . . LAGLSHAVSGKGSTAHTGTVDIVADKTLYQPGETAKMLITFPEPIDEAL
Query Conservation           .  
 
 
 
 
  
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Template Conservation       
  
       
 
                       
 
 
   
    
      
    
 
 
        
Template Sequence  VASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKI
Template Known Secondary structure 


TT

TTS
GGGS



TTS




SSSSB
TT




S



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   417..420.........430.........440.........450.........460.........470.........480.........490......
 
   690. ........700.........710.........720.........730.........740.. .......750........
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Query Sequence  LT. . . . . LERDRVEQQSLLSHPANWLTLQRLNDTQYEARVPVSNSFAPNITFSVLYTR. . . . NGQYSFQNAGIKVAVP. .
Query Conservation 

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Template Conservation      
 




 
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Template Sequence  THYNYLILSKGKIIHFGTREKF. . . . . . . . SDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCG
Template Known Secondary structure 
TT

........SSSS


GGGSS

SSS
B



S
Template Predicted Secondary structure 


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   497..500.........510........ .520.........530.........540.........550.........560........
 
   759760.........770.........780.........790.........800.........810.........820.........830.......
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Query Sequence  . QLDIRVKTDKTHYQPGELVNVELTSSLKGKPVSAQLTVGVVDEMIYALQPEIAPNIGKFFYPLGRNNVRTSSSLSFISY
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Template Conservation    
 
          

  
 
 
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Template Sequence  NQLQVHLSPDADAYSPGQTVSLNMATGMD. . . . . SWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNA
Template Known Secondary structure  S



SS

SSB
TT

SS
.....
BTTTT
SS

TT
STTTT



SSS

SSS
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   569570.........580.........590....... ..600.........610.........620.........630.........640...
 
   838.
Predicted Secondary structure 

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Query SS confidence 

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Query Sequence  DQ. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation    ..............................................................................
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Template Conservation   

  


   
                                         
           
             
Template Sequence  NVFHLAGLTFLTNANADDSQENDEPCKEILLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAF
Template Known Secondary structure  TT
SSS



SSS




S



TGGG

SSGGGS


SS
T

S
TTT
Template Predicted Secondary structure 


































































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   644.....650.........660.........670.........680.........690.........700.........710.........720...
 
   840.........850.........860.........870.........880.........890.........900.........910..
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Query Sequence  . . . . . . . ALSSEPVAPGATNRSERRVKMLERPRREEVDTAAWMPSLTTDKQGKAYFTFLMPDSLTRWRITARGMNGDGLV
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Template Conservation                                 

  






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Template Sequence  TECCVVASQLRANISLGRLHMKTLLPVSKPEIRSYFPESWLWEV. . . HLVPRRKQLQFALPDSLTTWEIQGIGISNTGIC
Template Known Secondary structure  TT












TT

S





B


...SS

SSS
TT
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   729730.........740.........750.........760.........770.. .......780.........790.........800.....
 
   913......920.........930.........940.........950.........960....... ..970........ .980....
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Query Sequence  GQGRAYLRSEKNLYMKWSMPTVYRVGDKPAAGLFIFSQQDNEPVALVTKFAGAEM. . . . . . . RQTLTLHKGAN. YISLTQ
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Template Conservation   
    
 
 


 
   

 

  

   
 
 
 
       
 
 
                  
       
 
 
Template Sequence  VADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPKCVRQKVEGSSSHLVTFTV
Template Known Secondary structure 




S

S
TT


SSS
B






TT
SS







B
TT

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   811........820.........830.........840.........850.........860.........870.........880.........890
 
   985....990........ .1000.........1010.........1020.........1030..... ....1040........
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Query Sequence  NIQQSGLLSAELQQ. NGQVQDSISTKLSFVDNSWPVEQQKNVMLGGGDNALM. . . . . . . . . . . . . . . LPEQASNIRLQSS
Query Conservation       
   
 
 
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Template Conservation   
   
   
 
 
      
 
 
 
 
 


       
  
                  

   

 
     

  
Template Sequence  LPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVK
Template Known Secondary structure 
SSS


TT



S
BTT
TTTS
B






TTB
TT


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   901........910.........920.........930.........940.........950.........960.........970.........980
 
   10491050....... ..1060.........1070.........1080.........1090.... .....1100.........1110...
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Query Sequence  ETPQEIFRN. . . . . . NLDALVDEPWGGVINTGSRLIPLSLAWRSLADHQSAA. . . . . . . . . ANDIRQMIQDNRLRLMQLA
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Template Conservation 
   
           
  

  
 

 




   
 
    

  
 
                  
  

 
 
 

Template Sequence  GLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYR
Template Known Secondary structure  SSTTSSSS


SSS

S
SSTTSTT
GGG
SS
GGGGB
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   981........990.........1000.........1010.........1020.........1030.........1040.........1050.........1060
 
   1114.....1120.........1130.........1140.........1150.........1160.........
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Query Sequence  GPGARFTWWGEDGNGDAFLTAWAWYADWQASQAIGVTQQPEYWQHMLDSYAEQADN. . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation    




 
      
 





   
  


  
  

   
 


  
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Template Sequence  NADYSYSVWKGG. SASTWLTAFALRVLGQ. VNKYVE. QNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEA
Template Known Secondary structure 
TTS
B
SSSSS.


.TTS
.

SB
TTS
B


SS






S
Template Predicted Secondary structure 









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   1061........1070.. .......1080........ .1090.... .....1100.........1110.........1120.........1130.......
 
   1170.........1180...... ...1190.........1200.........1210.........1220....... ..1230.........1240....
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Query Sequence  . . MPLLHRALVLAWAQEMN. . LPCKTLLKGLDEAIARRGTKTEDFSEEDTRDINDSLILDTP. ESPLADAVANVLTMTLL
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Template Conservation        


 

 

 
               

   
          
  

 



 
              
   
 
Template Sequence  RENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREAL
Template Known Secondary structure  TGGGS

SS
S
TTS
TT

Template Predicted Secondary structure 




















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   1138.1140.........1150.........1160.........1170.........1180.........1190.........1200.........1210.......
 
   1245....1250... ......1260.........1270.........1280.........1290..... ....1300.........1310.
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Query Sequence  KKAQLKSTV. . . . . . MPQVQQYAWDKAANSNQPLAHTVVLLNSGGDATQTAAILSGL. . . . . . . TAEQSTIERALAMNWL
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Template Sequence  VKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGL
Template Known Secondary structure  TTTTS

S
SS

SS


S


TT
S
SSS

STTTT
Template Predicted Secondary structure 



































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   1218.1220.........1230.........1240.........1250.........1260.........1270.........1280.........1290.......
 
   1312.......1320.........1330.........1340.........1350.........1360.........1370.........1380.........1390.
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Query Sequence  AKYMATMPPVVLPAPAGAWAKHKLTGGGEDWRWVGQGVPDILSFGDELSPQNVQVRWREPAKMAQQSNIPVTVERQLYRL
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Template Conservation    
            
 
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Template Sequence  TEYSLLVKQLRLSMDIDVSYKHKGALHN. . YKMTDKN. FLGRPVEVLLNDDLIVSTGFGSGLA. . . . . . TVHVTTVVHKT
Template Known Secondary structure  S









SSS




..



SSS.
S




SSS



S

S
......BS
Template Predicted Secondary structure 










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   1298.1300.........1310.........1320..... ....1330.. .......1340.........1350....... ..1360........
 
   1392.......1400.........1410.........1420......... 1430.........1440.........1450.........1460.........1470
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Query Sequence  IPGEEEMSFILQPVTSNEIDSDALYLDEITLTSEQDAV. LRYGQVEVPLPPGADVERTTWGISVNKPNAAKQQGQLLEKA
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Template Conservation          
 
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Template Sequence  STSEEVCSFYLK. IDTQDIYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQL. . . . . FTDYQ
Template Known Secondary structure 

SSS

S.






TT

SS


S

TT

SSTT
S.....
SB

Template Predicted Secondary structure 







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   13691370.........1380 .........1390.........1400.........1410.........1420.........1430....... ..1440..
 
   1471........1480.........1490.........1500.........1510.........1520.
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Query Sequence  RNEMGELAYMVPVKELTGTVTFRHLLRFSQKGQFVLPPARYVRSYAPAQQS
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Template Conservation       
 

   
   
  
  
       
   


 
 




 
    
Template Sequence  IKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQC
Template Known Secondary structure  TTS


SSS

SS

SS


TT
Template Predicted Secondary structure 



















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   1455....1460.........1470.........1480.........1490.........1500.....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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