Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	M	V	Q	P	K	S	Q	K	A	R	L	F	I	T	H	L	L	L	L	L	F	I	A	A	I	M	F	P	L	L	M	V	V	A	I	S	L	R	Q	G	N	F	A	T	G	S	L	I	P	E	Q	I	S	W	D	H	W	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																															?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	L	G	F	S	V	E	Q	A	D	G	R	I	T	P	P	P	F	P	V	L	L	W	L	W	N	S	V	K	V	A	G	I	S	A	I	G	I	V	A	L	S	T	T	C	A	Y	A	F	A	R	M	R	F	P	G	K	A	T
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	K	G	M	L	I	F	Q	M	F	P	A	V	L	S	L	V	A	L	Y	A	L	F	D	R	L	G	E	Y	I	P	F	I	G	L	N	T	H	G	G	V	I	F	A	Y	L	G	G	I	A	L	H	V	W	T	I	K	G	Y
Secondary structure
SS confidence
Disorder												?																		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	E	T	I	D	S	S	L	E	E	A	A	A	L	D	G	A	T	P	W	Q	A	F	R	L	V	L	L	P	L	S	V	P	I	L	A	V	V	F	I	L	S	F	I	A	A	I	T	E	V	P	V	A	S	L	L	L	R	D	V
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Sequence		N	S	Y	T	L	A	V	G	M	Q	Q	Y	L	N	P	Q	N	Y	L	W	G	D	F	A	A	A	A	V	M	S	A	L	P	I	T	I	V	F	L	L	A	Q	R	W	L	V	N	G	L	T	A	G	G	V	K	G
Secondary structure
SS confidence
Disorder		?	?										?	?	?			?																																	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2r6g chain G domain 1 Region: 7 - 296 Aligned: 284 Modelled: 290 Confidence: 100.0% Identity: 96% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3fh6 chain F Region: 7 - 283 Aligned: 268 Modelled: 277 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2r6g chain F Region: 50 - 280 Aligned: 222 Modelled: 231 Confidence: 100.0% Identity: 21% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2r6g chain F domain 2 Region: 56 - 280 Aligned: 216 Modelled: 225 Confidence: 100.0% Identity: 21% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C domain 1 Region: 9 - 283 Aligned: 244 Modelled: 248 Confidence: 100.0% Identity: 22% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 9 - 283 Aligned: 244 Modelled: 248 Confidence: 100.0% Identity: 22% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 3d31 chain D Region: 13 - 282 Aligned: 240 Modelled: 244 Confidence: 100.0% Identity: 23% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 3d31 chain C domain 1 Region: 13 - 282 Aligned: 240 Modelled: 244 Confidence: 100.0% Identity: 23% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3dhw chain A domain 1 Region: 81 - 280 Aligned: 191 Modelled: 200 Confidence: 99.8% Identity: 17% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F domain 1 Region: 7 - 43 Aligned: 37 Modelled: 37 Confidence: 88.0% Identity: 14% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 1l7v chain A Region: 1 - 28 Aligned: 28 Modelled: 26 Confidence: 33.6% Identity: 11% Fold: ABC transporter involved in vitamin B12 uptake, BtuC Superfamily: ABC transporter involved in vitamin B12 uptake, BtuC Family: ABC transporter involved in vitamin B12 uptake, BtuC Phyre2 PDB 2hx6 chain A Region: 175 - 202 Aligned: 28 Modelled: 28 Confidence: 26.8% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease; PDBTitle: solution structure analysis of the phage t42 endoribonuclease regb Phyre2 PDB 3ipd chain B Region: 6 - 31 Aligned: 26 Modelled: 26 Confidence: 10.0% Identity: 4% PDB header:exocytosis Chain: B: PDB Molecule:syntaxin-1a; PDBTitle: helical extension of the neuronal snare complex into the2 membrane, spacegroup i 21 21 21 Phyre2 PDB 1umq chain A Region: 176 - 206 Aligned: 31 Modelled: 31 Confidence: 9.7% Identity: 19% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 PDB 1umq chain A Region: 176 - 206 Aligned: 31 Modelled: 31 Confidence: 9.7% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1ntc chain A Region: 176 - 206 Aligned: 31 Modelled: 31 Confidence: 7.7% Identity: 16% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1eto chain B Region: 176 - 206 Aligned: 31 Modelled: 31 Confidence: 7.7% Identity: 10% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 1 d2r6gg1 2 c3fh6F_ 3 c2r6gF_ 4 d2r6gf2 5 d2onkc1 6 c2onkC_ 7 c3d31D_ 8 d3d31c1 9 d3dhwa1 10 d2r6gf1 11 d1l7va_ 12 c2hx6A_ 13 c3ipdB_ 14 c1umqA_ 15 d1umqa_ 16 d1ntca_ 17 d1etob_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2r6gg1 100.0 96 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 2 c3fh6F_ 100.0 18 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 3 c2r6gF_ 100.0 21 PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter 4 d2r6gf2 100.0 21 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 5 d2onkc1 100.0 22 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 6 c2onkC_ 100.0 22 PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda 7 c3d31D_ 100.0 23 PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans 8 d3d31c1 100.0 23 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 9 d3dhwa1 99.8 17 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 10 d2r6gf1 88.0 14 Fold:MalF N-terminal region-like Superfamily:MalF N-terminal region-like Family:MalF N-terminal region-like 11 d1l7va_ 33.6 11 Fold:ABC transporter involved in vitamin B12 uptake, BtuC Superfamily:ABC transporter involved in vitamin B12 uptake, BtuC Family:ABC transporter involved in vitamin B12 uptake, BtuC 12 c2hx6A_ 26.8 18 PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease; PDBTitle: solution structure analysis of the phage t42 endoribonuclease regb 13 c3ipdB_ 10.0 4 PDB header:exocytosis Chain: B: PDB Molecule:syntaxin-1a; PDBTitle: helical extension of the neuronal snare complex into the2 membrane, spacegroup i 21 21 21 14 c1umqA_ 9.7 19 PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity 15 d1umqa_ 9.7 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 16 d1ntca_ 7.7 16 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 17 d1etob_ 7.7 10 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0