Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	L	M	L	F	N	L	F	S	P	A	L	K	L	N	T	G	L	A	I	L	S	P	G	A	F	E	V	H	S	D	G	I	D	V	D	N	E	L	F	H	Y	P	I	K	K	A	Y	T	P	Y	N	I	H	T	Y	K	T	E
Secondary structure
SS confidence
Disorder		?	?	?		?	?	?				?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.
Sequence		E	V	V	N	Q	M	N	I	K	V	K	N	M	T	L	D	E	I	N	N	T	Y	C	N	N	D	Y	Y	N	Q	A	I	R	E	E	P	I	D	L	L	D	R	S	F	S	S	S	S	W	P	F
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2b5d chain X domain 1 Region: 88 - 111 Aligned: 18 Modelled: 24 Confidence: 32.8% Identity: 56% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Families 57/38 glycoside transferase middle domain Family: AmyC C-terminal domain-like Phyre2 PDB 3bgh chain B Region: 41 - 55 Aligned: 15 Modelled: 15 Confidence: 21.6% Identity: 60% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative neuraminyllactose-binding hemagglutinin homolog; PDBTitle: crystal structure of putative neuraminyllactose-binding hemagglutinin2 homolog from helicobacter pylori Phyre2 PDB 1ufa chain A domain 1 Region: 89 - 111 Aligned: 17 Modelled: 23 Confidence: 17.5% Identity: 59% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Families 57/38 glycoside transferase middle domain Family: AmyC C-terminal domain-like Phyre2 PDB 2i9i chain A Region: 41 - 55 Aligned: 15 Modelled: 15 Confidence: 16.6% Identity: 47% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of helicobacter pylori protein hp0492 Phyre2 PDB 2i9i chain A domain 1 Region: 41 - 55 Aligned: 15 Modelled: 15 Confidence: 16.6% Identity: 47% Fold: Anticodon-binding domain-like Superfamily: XCC0632-like Family: NLBH-like Phyre2 PDB 2cu1 chain A domain 1 Region: 82 - 108 Aligned: 27 Modelled: 27 Confidence: 14.9% Identity: 37% Fold: beta-Grasp (ubiquitin-like) Superfamily: CAD & PB1 domains Family: PB1 domain Phyre2 PDB 1jt6 chain A domain 2 Region: 41 - 67 Aligned: 27 Modelled: 27 Confidence: 12.8% Identity: 30% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 2dlo chain A domain 2 Region: 73 - 90 Aligned: 18 Modelled: 18 Confidence: 12.2% Identity: 22% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 2rbg chain B Region: 52 - 86 Aligned: 33 Modelled: 35 Confidence: 12.0% Identity: 24% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative uncharacterized protein st0493; PDBTitle: crystal structure of hypothetical protein(st0493) from2 sulfolobus tokodaii Phyre2 PDB 2npt chain B domain 1 Region: 64 - 108 Aligned: 45 Modelled: 45 Confidence: 11.1% Identity: 27% Fold: beta-Grasp (ubiquitin-like) Superfamily: CAD & PB1 domains Family: PB1 domain Phyre2 PDB 1f2j chain A Region: 11 - 35 Aligned: 25 Modelled: 25 Confidence: 6.6% Identity: 36% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3kx6 chain C Region: 11 - 35 Aligned: 25 Modelled: 25 Confidence: 6.6% Identity: 32% PDB header:lyase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-1,6-bisphosphate aldolase from babesia2 bovis at 2.1a resolution Phyre2 PDB 1xrx chain D Region: 34 - 43 Aligned: 10 Modelled: 10 Confidence: 6.1% Identity: 60% PDB header:replication inhibitor Chain: D: PDB Molecule:seqa protein; PDBTitle: crystal structure of a dna-binding protein Phyre2 PDB 1xrx chain A domain 1 Region: 34 - 43 Aligned: 10 Modelled: 10 Confidence: 6.1% Identity: 60% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: SeqA N-terminal domain-like Phyre2 1 d2b5dx1 2 c3bghB_ 3 d1ufaa1 4 c2i9iA_ 5 d2i9ia1 6 d2cu1a1 7 d1jt6a2 8 d2dloa2 9 c2rbgB_ 10 d2nptb1 11 d1f2ja_ 12 c3kx6C_ 13 c1xrxD_ 14 d1xrxa1

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2b5dx1 32.8 56 Fold:immunoglobulin/albumin-binding domain-like Superfamily:Families 57/38 glycoside transferase middle domain Family:AmyC C-terminal domain-like 2 c3bghB_ 21.6 60 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative neuraminyllactose-binding hemagglutinin homolog; PDBTitle: crystal structure of putative neuraminyllactose-binding hemagglutinin2 homolog from helicobacter pylori 3 d1ufaa1 17.5 59 Fold:immunoglobulin/albumin-binding domain-like Superfamily:Families 57/38 glycoside transferase middle domain Family:AmyC C-terminal domain-like 4 c2i9iA_ 16.6 47 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of helicobacter pylori protein hp0492 5 d2i9ia1 16.6 47 Fold:Anticodon-binding domain-like Superfamily:XCC0632-like Family:NLBH-like 6 d2cu1a1 14.9 37 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:PB1 domain 7 d1jt6a2 12.8 30 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 8 d2dloa2 12.2 22 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 9 c2rbgB_ 12.0 24 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative uncharacterized protein st0493; PDBTitle: crystal structure of hypothetical protein(st0493) from2 sulfolobus tokodaii 10 d2nptb1 11.1 27 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:PB1 domain 11 d1f2ja_ 6.6 36 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 12 c3kx6C_ 6.6 32 PDB header:lyase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: crystal structure of fructose-1,6-bisphosphate aldolase from babesia2 bovis at 2.1a resolution 13 c1xrxD_ 6.1 60 PDB header:replication inhibitor Chain: D: PDB Molecule:seqa protein; PDBTitle: crystal structure of a dna-binding protein 14 d1xrxa1 6.1 60 Fold:Ribbon-helix-helix Superfamily:Ribbon-helix-helix Family:SeqA N-terminal domain-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0