PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c8dyoA_

Fold library id	PDB Header	Molecule	Title
c8dyoA_	7.10	PDB header: protein transport	Chain: A: PDB Molecule: importin-4;

Links to external resources
Added to library: Sat Sep 24 14:06:28 2022

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence A G L E Q L L R E L L L P D T E R I R R A T E Q L Q I V L R A P A A L P A L C D L L A S A A D P Q I R Q F A A V L T R R R L N T R W R R L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
T T T
S S
S S T T T T G G G
S
T T S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence A E Q R E S L K S L I L T A L Q R E T E H C V S L S L A Q L S A T I F R K E G L E A W P Q L L Q L L Q H S T H S P H S P E R E M G L L L L S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T T S S
T T S S
S S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence V V V T S R P E A F Q P H H R E L L R L L N E T L G E V G S P G L L F Y S L R T L T T M A P Y L S T E D V P L A R M L V P K L I M A M Q T L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S S
T T
G G G
S S
T T
S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence I P I D E A K A C E A L E A L D E L L E S E V P V I T P Y L S E V L T F C L E V A R N V A L G N A I R I R I L C C L T F L V K V K S K A L L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
S S
T T T T T S
T
S S
T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence K N R L L P P L L H T L F P I V A A E P P P G Q L D P E D Q D S E E E E L E I E L M G E T P K H F A V Q V V D M L A L H L P P E K L C P Q L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T
T T
T T
S
S
S
S S
T T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence M P M L E E A L R S E S P Y Q R K A G L L V L A V L S D G A G D H I R Q R L L P P L L Q I V C K G L E D P S Q V V R N A A L F A L G Q F S E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S S
S
S
S S T T T T T T S
T T S T

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence N L Q P H I S S Y S R E V M P L L L A Y L K S V P L G H T H H L A K A C Y A L E N F V E N L G P K V Q P Y L P E L M E C M L Q L L R N P S S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S G G G S S S
T T T
S S
S S S S G G G
S G G G G G G T T T T T S S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence P R A K E L A V S A L G A I A T A A Q A S L L P Y F P A I M E H L R E F L L T G R E D L Q P V Q I Q S L E T L G V L A R A V G E P M R P L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T T T T S
T T
G G G

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence E E C C Q L G L G L C D Q V D D P D L R R C T Y S L F A A L S G L M G E G L A P H L E Q I T T L M L L S L R S T E G I N A F F D E K E D T C

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S S S T T S S S
T T T T T T S S T T S T T S S S
S
T T

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence A A V G E I S V N T S V A F L P Y M E S V F E E V F K L L E C P H L N V R K A A H E A L G Q F C C A L H K A C Q S C P S E P N T A A L Q A A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S
T T T T T S
S
T T S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence L A R V V P S Y M Q A V N R E R E R Q V V M A V L E A L T G V L R S C G T L T L K P P G R L A E L C G V L K A V L Q R K T A C Q D T D E E E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T S
S T
G G G G
S T T T T T S S T T
S S
S S

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence E E E D D D Q A E Y D A M L L E H A G E A I P A L A A A A G G D S F A P F F A G F L P L L V C K T K Q G C T V A E K S F A V G T L A E T I Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T G G G T T T T T G G G
S S
T T G G G S T T S

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence G L G A A S A Q F V S R L L P V L L S T A Q E A D P E V R S N A I F G M G V L A E H G G H P A Q E H F P K L L G L L F P L L A R E R H D R V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T S S S S S S T S
S S G G G G G G
S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence R D N I C G A L A R L L M A S P T R K P E P Q V L A A L L H A L P L K E D L E E W V T I G R L F S F L D Q V I D V A P E L L R I C S L I L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S
T T T
S S
T T
T T
S
S
S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . .

Sequence D N K I P P D T K A A L L L L L T F Q A A L G S L P V D K A Q E L Q A V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
G G G T T S S S G G G
S
S S
G G G T
S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	A	G	L	E	Q	L	L	R	E	L	L	L	P	D	T	E	R	I	R	R	A	T	E	Q	L	Q	I	V	L	R	A	P	A	A	L	P	A	L	C	D	L	L	A	S	A	A	D	P	Q	I	R	Q	F	A	A	V	L	T	R	R	R	L	N	T	R	W	R	R	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T	S									T					T	T				S	S		S	S	T	T	T	T	G	G	G		S																				T	T	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	A	E	Q	R	E	S	L	K	S	L	I	L	T	A	L	Q	R	E	T	E	H	C	V	S	L	S	L	A	Q	L	S	A	T	I	F	R	K	E	G	L	E	A	W	P	Q	L	L	Q	L	L	Q	H	S	T	H	S	P	H	S	P	E	R	E	M	G	L	L	L	L	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	T	T	S													S																		T	T	S	S		S	S																	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	V	V	V	T	S	R	P	E	A	F	Q	P	H	H	R	E	L	L	R	L	L	N	E	T	L	G	E	V	G	S	P	G	L	L	F	Y	S	L	R	T	L	T	T	M	A	P	Y	L	S	T	E	D	V	P	L	A	R	M	L	V	P	K	L	I	M	A	M	Q	T	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S	S	S	S																T	T																			G	G	G				S	S		T	T			S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	I	P	I	D	E	A	K	A	C	E	A	L	E	A	L	D	E	L	L	E	S	E	V	P	V	I	T	P	Y	L	S	E	V	L	T	F	C	L	E	V	A	R	N	V	A	L	G	N	A	I	R	I	R	I	L	C	C	L	T	F	L	V	K	V	K	S	K	A	L	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	T																	S	S			T	T	T	T	T	S													T			S	S		T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	K	N	R	L	L	P	P	L	L	H	T	L	F	P	I	V	A	A	E	P	P	P	G	Q	L	D	P	E	D	Q	D	S	E	E	E	E	L	E	I	E	L	M	G	E	T	P	K	H	F	A	V	Q	V	V	D	M	L	A	L	H	L	P	P	E	K	L	C	P	Q	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S															T				T	T					T	T			S				S			S							S																S			T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	M	P	M	L	E	E	A	L	R	S	E	S	P	Y	Q	R	K	A	G	L	L	V	L	A	V	L	S	D	G	A	G	D	H	I	R	Q	R	L	L	P	P	L	L	Q	I	V	C	K	G	L	E	D	P	S	Q	V	V	R	N	A	A	L	F	A	L	G	Q	F	S	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T			S	S																	S								S		S	S	T	T	T	T					T	T	S		T	T	S															T
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	N	L	Q	P	H	I	S	S	Y	S	R	E	V	M	P	L	L	L	A	Y	L	K	S	V	P	L	G	H	T	H	H	L	A	K	A	C	Y	A	L	E	N	F	V	E	N	L	G	P	K	V	Q	P	Y	L	P	E	L	M	E	C	M	L	Q	L	L	R	N	P	S	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T		S	G	G	G	S	S	S		T	T											T			S	S												S	S	S	S	G	G	G		S	G	G	G	G	G	G									T	T	T	T	T	S	S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	P	R	A	K	E	L	A	V	S	A	L	G	A	I	A	T	A	A	Q	A	S	L	L	P	Y	F	P	A	I	M	E	H	L	R	E	F	L	L	T	G	R	E	D	L	Q	P	V	Q	I	Q	S	L	E	T	L	G	V	L	A	R	A	V	G	E	P	M	R	P	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																			T	T	T	T	T	T	T													S				T	T																					G	G	G
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	E	E	C	C	Q	L	G	L	G	L	C	D	Q	V	D	D	P	D	L	R	R	C	T	Y	S	L	F	A	A	L	S	G	L	M	G	E	G	L	A	P	H	L	E	Q	I	T	T	L	M	L	L	S	L	R	S	T	E	G	I	N	A	F	F	D	E	K	E	D	T	C
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S	S	S	S					T	T	S	S	S			T	T	T	T	T	T													S	S	T	T	S	T	T	S												S	S		S					T	T
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	A	A	V	G	E	I	S	V	N	T	S	V	A	F	L	P	Y	M	E	S	V	F	E	E	V	F	K	L	L	E	C	P	H	L	N	V	R	K	A	A	H	E	A	L	G	Q	F	C	C	A	L	H	K	A	C	Q	S	C	P	S	E	P	N	T	A	A	L	Q	A	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	T	S		T	T	T	T														T	S			S													T	T											S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	L	A	R	V	V	P	S	Y	M	Q	A	V	N	R	E	R	E	R	Q	V	V	M	A	V	L	E	A	L	T	G	V	L	R	S	C	G	T	L	T	L	K	P	P	G	R	L	A	E	L	C	G	V	L	K	A	V	L	Q	R	K	T	A	C	Q	D	T	D	E	E	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										T	T	T	T	S				S																T			G	G	G	G		S	T	T	T	T	T										S	S	T	T		S	S				S	S
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	E	E	E	D	D	D	Q	A	E	Y	D	A	M	L	L	E	H	A	G	E	A	I	P	A	L	A	A	A	A	G	G	D	S	F	A	P	F	F	A	G	F	L	P	L	L	V	C	K	T	K	Q	G	C	T	V	A	E	K	S	F	A	V	G	T	L	A	E	T	I	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S								T								G	G	G	T	T	T	T	T	G	G	G		S	S		T	T	G	G	G													S	T	T	S
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	G	L	G	A	A	S	A	Q	F	V	S	R	L	L	P	V	L	L	S	T	A	Q	E	A	D	P	E	V	R	S	N	A	I	F	G	M	G	V	L	A	E	H	G	G	H	P	A	Q	E	H	F	P	K	L	L	G	L	L	F	P	L	L	A	R	E	R	H	D	R	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																								S		T	T	S	S												S	S	S	S						T					S		S	S	G	G	G	G	G	G			S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	R	D	N	I	C	G	A	L	A	R	L	L	M	A	S	P	T	R	K	P	E	P	Q	V	L	A	A	L	L	H	A	L	P	L	K	E	D	L	E	E	W	V	T	I	G	R	L	F	S	F	L	D	Q	V	I	D	V	A	P	E	L	L	R	I	C	S	L	I	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														T	S	S						T	T								T				S	S		T	T									T	T						S		S													S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.
Sequence	D	N	K	I	P	P	D	T	K	A	A	L	L	L	L	L	T	F	Q	A	A	L	G	S	L	P	V	D	K	A	Q	E	L	Q	A	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S				G	G	G	T	T	S	S	S	G	G	G								S		S	S		G	G	G	T		S