PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c7mbqB_

Fold library id	PDB Header	Molecule	Title
c7mbqB_	2.30	PDB header: transport protein	Chain: B: PDB Molecule: transient receptor potential melastatin 5;

Links to external resources
Added to library: Sat Jul 10 08:54:18 2021

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence R L G D I D F T G V S R T R G K F V R V T S S T D P A E I Y Q I L T K Q W G L A P P H L V V A L M G G D E V A Q L K P W L R D T L R K G L V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
T T S
T T T
S
S S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence K A A Q S T G A W I L T S G L R F G I T K N L G Q A V R D H S L A S T S P K V R V V A I G I A P W N M I Q N R D L L L S A K P D H P A T Y P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S
B S S
S
S S
G G G B T T S
S S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence T E D L P Y G A V Y S L D C N H S H F I L V D E D P K R P G A T G E M R V K M L K H I S L Q R T G Y G G T G S I E I P V L C L L V H G E P R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
B
B
T T
S S
S
T
T T T
S
G G

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence I L Q K M Y K N I Q N S I P W L I L A G S G G V A D I L V T L M D R G C W D A D I V Q E L L I N T F P D G L H S T E I T S W T K L I Q R I L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G T T
T T S S S S
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence D H G H L L T V H D P E Q D S E L D T V I L K A L V K A C K S Q S Q E A Q D F L D E L K L A V A W N R V D I A K S E I F S G D V Q W S A Q D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T T T
S G G G T
T T T S S S S
T G G

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence L E E V M M E A L V N D K P D F V R L F V D N G V N I K Q F L T Y G R L Q E L Y C S V S E K N L L H T L L L K K N Q E R Q A Q L K F R F T F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G T T
T T
B
S S S
S S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence H E V S K V L K D F L D D T C K G F Y Q K L N L P D M D R R C E H P W R D L F L W A I L Q N R Q E M A N Y F W A M G P E A V A A A L V G C K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S S S
T T S S S
T T S B
S S T T
T
S S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence I M K E M A H L A T E A E S A R S M K N A K Y E Q F A M D L F S E C Y S N S E D R A Y S L L V R K T C C W S K A T V L N I A T L A E A K C F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S S
T S S B B
T T T T S
B T

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence F A H D G V Q A L L T K V W W G A M R T D T S I S R L V L T F F I P P L V W T S L I K F N P E S A T F I R V V L R R W N R F W S A P V T V F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S T T B
T T
S G G G G G S T T S
B
T S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence M G N V I M Y F A F L I L F S Y V L L L D F R P P P P Y G P S A A E I I L Y F W V F T L V L E E I R Q S F F T D E D M S I L K K M K L Y V E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S T T T
S S S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence D N W N K C D M V A I S L F V V G L S C R M A M S T Y E A G R T V L A L D F M V F T L R L I H I F A I H K Q L G P K I I I V E R M I K D V F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T S G G G G G G G G G G S T T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence F F L F F L S V W L I A Y G V T T Q A L L H P N D P R I D W V F R R A L Y R P Y L H I F G Q I P L E E I D A A K M P D D N C T T D V Q E I I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T T
G G G T
G G G
B

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence L G T L P P C P N I Y A N W L V I L L L V I Y L L V T N V L L L N L L I A M F S Y T F Q V V Q E N A D I F W K F Q R Y N L I V E Y H S R P A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S
B
T T T T S S
S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence L A P P F I I I S H I T Q A L L S F I K D L L E R E L P S G L D Q K L M T W E T V Q K E N Y L A K L E H E H R E S S G E R L R Y T S S K V Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S T
S S B
T S

. . . . . . . . . 990 . . . . . .

Sequence T L L R M V G G F K D Q E K R M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	R	L	G	D	I	D	F	T	G	V	S	R	T	R	G	K	F	V	R	V	T	S	S	T	D	P	A	E	I	Y	Q	I	L	T	K	Q	W	G	L	A	P	P	H	L	V	V	A	L	M	G	G	D	E	V	A	Q	L	K	P	W	L	R	D	T	L	R	K	G	L	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	S	S											T	T	S											T	T	T						S										S	S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	K	A	A	Q	S	T	G	A	W	I	L	T	S	G	L	R	F	G	I	T	K	N	L	G	Q	A	V	R	D	H	S	L	A	S	T	S	P	K	V	R	V	V	A	I	G	I	A	P	W	N	M	I	Q	N	R	D	L	L	L	S	A	K	P	D	H	P	A	T	Y	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S	S									B	S	S																		S			S	S										G	G	G	B	T	T					S				S	S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	T	E	D	L	P	Y	G	A	V	Y	S	L	D	C	N	H	S	H	F	I	L	V	D	E	D	P	K	R	P	G	A	T	G	E	M	R	V	K	M	L	K	H	I	S	L	Q	R	T	G	Y	G	G	T	G	S	I	E	I	P	V	L	C	L	L	V	H	G	E	P	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S	S	S		B		B		T	T											S	S		S																T						T	T	T													S			G	G
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	I	L	Q	K	M	Y	K	N	I	Q	N	S	I	P	W	L	I	L	A	G	S	G	G	V	A	D	I	L	V	T	L	M	D	R	G	C	W	D	A	D	I	V	Q	E	L	L	I	N	T	F	P	D	G	L	H	S	T	E	I	T	S	W	T	K	L	I	Q	R	I	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G										T	T							T	T	S	S	S												S																T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	D	H	G	H	L	L	T	V	H	D	P	E	Q	D	S	E	L	D	T	V	I	L	K	A	L	V	K	A	C	K	S	Q	S	Q	E	A	Q	D	F	L	D	E	L	K	L	A	V	A	W	N	R	V	D	I	A	K	S	E	I	F	S	G	D	V	Q	W	S	A	Q	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T						T	T	T	T																						S	G	G	G											T								T	T	T	S	S	S	S				T	G	G
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	L	E	E	V	M	M	E	A	L	V	N	D	K	P	D	F	V	R	L	F	V	D	N	G	V	N	I	K	Q	F	L	T	Y	G	R	L	Q	E	L	Y	C	S	V	S	E	K	N	L	L	H	T	L	L	L	K	K	N	Q	E	R	Q	A	Q	L	K	F	R	F	T	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G										T	T											T	T								B													S	S	S																				S	S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	H	E	V	S	K	V	L	K	D	F	L	D	D	T	C	K	G	F	Y	Q	K	L	N	L	P	D	M	D	R	R	C	E	H	P	W	R	D	L	F	L	W	A	I	L	Q	N	R	Q	E	M	A	N	Y	F	W	A	M	G	P	E	A	V	A	A	A	L	V	G	C	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									T	T	T	S	S	S		T	T	S	S	S							T	T	S	B		S	S												T	T											T		S	S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	I	M	K	E	M	A	H	L	A	T	E	A	E	S	A	R	S	M	K	N	A	K	Y	E	Q	F	A	M	D	L	F	S	E	C	Y	S	N	S	E	D	R	A	Y	S	L	L	V	R	K	T	C	C	W	S	K	A	T	V	L	N	I	A	T	L	A	E	A	K	C	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										S	S	S								S																		T	S	S								B	B		T	T	T	T	S		B									T
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	F	A	H	D	G	V	Q	A	L	L	T	K	V	W	W	G	A	M	R	T	D	T	S	I	S	R	L	V	L	T	F	F	I	P	P	L	V	W	T	S	L	I	K	F	N	P	E	S	A	T	F	I	R	V	V	L	R	R	W	N	R	F	W	S	A	P	V	T	V	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	S													T	T	B		T	T												S	G	G	G	G	G	S	T	T	S		B																				T	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	M	G	N	V	I	M	Y	F	A	F	L	I	L	F	S	Y	V	L	L	L	D	F	R	P	P	P	P	Y	G	P	S	A	A	E	I	I	L	Y	F	W	V	F	T	L	V	L	E	E	I	R	Q	S	F	F	T	D	E	D	M	S	I	L	K	K	M	K	L	Y	V	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																				T					S	T	T	T																										S	S	S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	D	N	W	N	K	C	D	M	V	A	I	S	L	F	V	V	G	L	S	C	R	M	A	M	S	T	Y	E	A	G	R	T	V	L	A	L	D	F	M	V	F	T	L	R	L	I	H	I	F	A	I	H	K	Q	L	G	P	K	I	I	I	V	E	R	M	I	K	D	V	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S																					T	S	G	G	G																			G	G	G	G	G	G	G	S	T	T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	F	F	L	F	F	L	S	V	W	L	I	A	Y	G	V	T	T	Q	A	L	L	H	P	N	D	P	R	I	D	W	V	F	R	R	A	L	Y	R	P	Y	L	H	I	F	G	Q	I	P	L	E	E	I	D	A	A	K	M	P	D	D	N	C	T	T	D	V	Q	E	I	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																							T	T																			T	T	T				G	G	G	T		G	G	G							B
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	L	G	T	L	P	P	C	P	N	I	Y	A	N	W	L	V	I	L	L	L	V	I	Y	L	L	V	T	N	V	L	L	L	N	L	L	I	A	M	F	S	Y	T	F	Q	V	V	Q	E	N	A	D	I	F	W	K	F	Q	R	Y	N	L	I	V	E	Y	H	S	R	P	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	S	S		B					T	T																	T																				T																		S	S		S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	L	A	P	P	F	I	I	I	S	H	I	T	Q	A	L	L	S	F	I	K	D	L	L	E	R	E	L	P	S	G	L	D	Q	K	L	M	T	W	E	T	V	Q	K	E	N	Y	L	A	K	L	E	H	E	H	R	E	S	S	G	E	R	L	R	Y	T	S	S	K	V	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S		S	S	T																		S	S	B																															T	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.
Sequence	T	L	L	R	M	V	G	G	F	K	D	Q	E	K	R	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)