PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c6xr4B_

Fold library id	PDB Header	Molecule	Title
c6xr4B_	14.00	PDB header: signaling protein, transferase	Chain: B: PDB Molecule: leucine-rich repeat serine/threonine-protein kinase 2;

Links to external resources
Added to library: Sat Aug 22 15:33:58 2020

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence Y N R M K L M I V G N T G S G K T T L L Q Q L M K T K K S D L G M Q S A T V G I D V K D W P I Q I R D K R K R D L V L N V W D F A G R E E F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S T T S S
S S S S S
S S
T T S G G G G
T T
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence Y S T H P H F M T Q R A L Y L A V Y D L S K G Q A E V D A M K P W L F N I K A R A S S S P V I L V G T H L D V S D E K Q R K A C M S K I T K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S
S S
T T T T T T T S
T T T S S S
T T T T S
T T S T T T S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence E L L N K R G F P A I R D Y H F V N A T E E S D A L A K L R K T I I N E S L N F K I R P D C Y V E L E K I I L S E R K N V P I E F P V I D R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S T T T T
S
S T T
S T T S S G G G
S T
T T S S
S B

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence K R L L Q L V R E N Q L Q L D E N E L P H A V H F L N E S G V L L H F Q D P A L Q L S D L Y F V E P K W L C K I M A Q I L T V K V E G C P K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T S
S S T S S B
S S T T T T
S S S
B B
S
T T S S S T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence H P K G I I S R R D V E K F L S K K R K F P K N Y M S Q Y F K L L E K F Q I A L P I G E E Y L L V I I I R L Y E M P Y F P M G F W S R L I N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T S S S S S S
T T S
S S S
S
S S
T T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence R L L E I S P Y M L S G R E R A L R P N R M Y W R Q G I Y L N W S P E A Y C L V G S E V L D N H P E S F L K I T V P S C R K G C I L L G Q V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S S S
S S S
T T S S T T
S S
S S S
T T
S T T

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence V D H I D S L M E E W F P G L L E I D I C G E G E T L L K K W A L Y S F N D G E E H Q K I L L D D L M K K A E E G F L L G D G S F G S V Y R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T T
S S
S S
T T
T T T
T S
S S
S S S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence A A Y E G E E V A V K I F N K H T S L R L L R Q E L V V L C H L H H P S L I S L L A A G I R P R M L V M E L A S K G S L D R L L Q Q D K A S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
S
S S
T
S S B
B
S S
S S
T
T T S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence L T R T L Q H R I A L H V A D G L R Y L H S A M I I Y R D L K P H N V L L F T L Y P N A A I I A K I A D Y G T A Q Y C C R M G I K T S E G T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
S G G G
S
S T T
S
G G G
S S
S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence P G F R A P E V A R G N V I Y N Q Q A D V Y S F G L L L Y D I L T T G G R I V E G L K F P N E F D E L E I Q G K L P D P V K E Y G C A P W P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G S
G G G G
T T
T T
S T T T T T T T T T S
S S T T
T
T

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence M V E K L I K Q C L K E N P Q E R P T S A Q V F D I L N S A R R I L L P K N V I V E C M V A T N A S I W L G C G H T D R G Q L S F L D L N T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S T T S S
S S
B S
S S T T S S S
T T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence E G Y T S E E V A D S R I L C L A L V H L P V E K E S W I V S G T Q S G T L L V I N T E D G K K R H T L E K M T D S V T C L Y C N S F Q K N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
T T T T
T T S
S S
S S
S S
S S S

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence F L L V G T A D G K L A I F E D K T V K L K G A A P L K I L N I G N V S T P L M C L S E V M W G G C G T K I F S F S N D F T I Q K L I E T R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S G G G T T S T T
S
S
T T S
B
S S S T T
S S
T T

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence T S Q L F S Y A A F S D S N I I T V V V D T A L Y I A K Q N S P V V E V W D K K T E K L C G L I D C V H F L R E M S Y S G R V K T L C L Q K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S
S S
S S S T T
T T T T T T T S
T

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040

Sequence N T A L W I G T G G G H I L L L D L S T R R L I R V I Y N F C N S V R V M M T A Q N V M L V L G Y N R E I Q S C L T V W

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S S
S S S
S
S S S
S S
T T S B

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	Y	N	R	M	K	L	M	I	V	G	N	T	G	S	G	K	T	T	L	L	Q	Q	L	M	K	T	K	K	S	D	L	G	M	Q	S	A	T	V	G	I	D	V	K	D	W	P	I	Q	I	R	D	K	R	K	R	D	L	V	L	N	V	W	D	F	A	G	R	E	E	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										S	S	T	T	S	S											S	S	S	S	S							S	S												T	T	S	G	G	G	G									T	T			T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	Y	S	T	H	P	H	F	M	T	Q	R	A	L	Y	L	A	V	Y	D	L	S	K	G	Q	A	E	V	D	A	M	K	P	W	L	F	N	I	K	A	R	A	S	S	S	P	V	I	L	V	G	T	H	L	D	V	S	D	E	K	Q	R	K	A	C	M	S	K	I	T	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S	S							S	S									T	T	T	T	T	T	T	S		T										T	T	S	S	S											T	T	T	T	S		T	T	S	T	T	T	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	E	L	L	N	K	R	G	F	P	A	I	R	D	Y	H	F	V	N	A	T	E	E	S	D	A	L	A	K	L	R	K	T	I	I	N	E	S	L	N	F	K	I	R	P	D	C	Y	V	E	L	E	K	I	I	L	S	E	R	K	N	V	P	I	E	F	P	V	I	D	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	T	T	T	T			S									S	T	T		S	T	T											S	S	G	G	G						S														T		T	T	S	S		S	B
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	K	R	L	L	Q	L	V	R	E	N	Q	L	Q	L	D	E	N	E	L	P	H	A	V	H	F	L	N	E	S	G	V	L	L	H	F	Q	D	P	A	L	Q	L	S	D	L	Y	F	V	E	P	K	W	L	C	K	I	M	A	Q	I	L	T	V	K	V	E	G	C	P	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										T	T	T	T	S		S	S													T	S	S	B			S	S	T	T	T	T		S	S	S		B	B														S		T	T	S	S	S	T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	H	P	K	G	I	I	S	R	R	D	V	E	K	F	L	S	K	K	R	K	F	P	K	N	Y	M	S	Q	Y	F	K	L	L	E	K	F	Q	I	A	L	P	I	G	E	E	Y	L	L	V	I	I	I	R	L	Y	E	M	P	Y	F	P	M	G	F	W	S	R	L	I	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S				T	T	S					S	S	S	S	S																	T	T	S					S	S	S							S						S	S			T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	R	L	L	E	I	S	P	Y	M	L	S	G	R	E	R	A	L	R	P	N	R	M	Y	W	R	Q	G	I	Y	L	N	W	S	P	E	A	Y	C	L	V	G	S	E	V	L	D	N	H	P	E	S	F	L	K	I	T	V	P	S	C	R	K	G	C	I	L	L	G	Q	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T	T	S	S	S		S	S	S					T	T	S	S	T	T				S	S							S	S	S								T	T						S	T	T
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	V	D	H	I	D	S	L	M	E	E	W	F	P	G	L	L	E	I	D	I	C	G	E	G	E	T	L	L	K	K	W	A	L	Y	S	F	N	D	G	E	E	H	Q	K	I	L	L	D	D	L	M	K	K	A	E	E	G	F	L	L	G	D	G	S	F	G	S	V	Y	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	T	T										S	S		S	S														T	T							T	T	T												T	S					S	S				S	S	S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	A	A	Y	E	G	E	E	V	A	V	K	I	F	N	K	H	T	S	L	R	L	L	R	Q	E	L	V	V	L	C	H	L	H	H	P	S	L	I	S	L	L	A	A	G	I	R	P	R	M	L	V	M	E	L	A	S	K	G	S	L	D	R	L	L	Q	Q	D	K	A	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	T									S		S	S													T				S	S	B			B						S	S									S	S								T		T	T	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	L	T	R	T	L	Q	H	R	I	A	L	H	V	A	D	G	L	R	Y	L	H	S	A	M	I	I	Y	R	D	L	K	P	H	N	V	L	L	F	T	L	Y	P	N	A	A	I	I	A	K	I	A	D	Y	G	T	A	Q	Y	C	C	R	M	G	I	K	T	S	E	G	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																								T				T	T		S	G	G	G				S			S	T	T		S								G	G	G					S	S					S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	P	G	F	R	A	P	E	V	A	R	G	N	V	I	Y	N	Q	Q	A	D	V	Y	S	F	G	L	L	L	Y	D	I	L	T	T	G	G	R	I	V	E	G	L	K	F	P	N	E	F	D	E	L	E	I	Q	G	K	L	P	D	P	V	K	E	Y	G	C	A	P	W	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G	S		G	G	G	G		T	T					T																	T							S	T	T	T	T	T	T	T	T	T	S				S	S	T	T		T						T
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	M	V	E	K	L	I	K	Q	C	L	K	E	N	P	Q	E	R	P	T	S	A	Q	V	F	D	I	L	N	S	A	R	R	I	L	L	P	K	N	V	I	V	E	C	M	V	A	T	N	A	S	I	W	L	G	C	G	H	T	D	R	G	Q	L	S	F	L	D	L	N	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										S		S	S	T	T	S	S			S								S									B	S										S	S							T	T	S	S	S								T	T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	E	G	Y	T	S	E	E	V	A	D	S	R	I	L	C	L	A	L	V	H	L	P	V	E	K	E	S	W	I	V	S	G	T	Q	S	G	T	L	L	V	I	N	T	E	D	G	K	K	R	H	T	L	E	K	M	T	D	S	V	T	C	L	Y	C	N	S	F	Q	K	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	S	S											T	T	T	T									T	T	S							S	S		S	S									S	S										S	S	S
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	F	L	L	V	G	T	A	D	G	K	L	A	I	F	E	D	K	T	V	K	L	K	G	A	A	P	L	K	I	L	N	I	G	N	V	S	T	P	L	M	C	L	S	E	V	M	W	G	G	C	G	T	K	I	F	S	F	S	N	D	F	T	I	Q	K	L	I	E	T	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	S							G	G	G	T	T	S	T	T				S						S		T	T	S				B			S	S	S					T	T							S	S									T	T
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	T	S	Q	L	F	S	Y	A	A	F	S	D	S	N	I	I	T	V	V	V	D	T	A	L	Y	I	A	K	Q	N	S	P	V	V	E	V	W	D	K	K	T	E	K	L	C	G	L	I	D	C	V	H	F	L	R	E	M	S	Y	S	G	R	V	K	T	L	C	L	Q	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T		S						S	S								S	S	S						T	T									T	T	T	T												T	T	T	S													T
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040
Sequence	N	T	A	L	W	I	G	T	G	G	G	H	I	L	L	L	D	L	S	T	R	R	L	I	R	V	I	Y	N	F	C	N	S	V	R	V	M	M	T	A	Q	N	V	M	L	V	L	G	Y	N	R	E	I	Q	S	C	L	T	V	W
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T							S	S	S							S	S	S								S		S	S	S									S	S									T	T	S	B