PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c6w1sI_

Fold library id	PDB Header	Molecule	Title
c6w1sI_	4.02	PDB header: gene regulation	Chain: I: PDB Molecule: mediator of rna polymerase ii transcription subunit 14;

Links to external resources
Added to library: Sat Mar 13 08:32:59 2021

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence L V H A R L P S F A I P Y A I D V L Y P R L P T C I R D K I I P P D P I T K I E K Q A T L H Q L N Q I L R H R L V T T D L P P Q L A N L T V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S T T
S S
S S
T T S
T T T T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence A N G R V K F R V E G E F E A T L T V M E V P W R L L K L E I L V R A L V H S M Q I D F I H Q L V Q S R L F A D E K P L Q D M Y N C L H C F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
T T T S
B
B
S
S
T T T T
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence C L S L Q L E V L H S Q T L M L I R E R W G D L V Q V E R Y H A G K S L S L S V W N Q S V H K V T I K I D E N D V S K P L Q I F H D P P L R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S S S S
S S S
T T S
S S S S
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence A M K I D H L S I E K L L I D S V H A R A H Q R L Q E L K A I L R S F N A S I E T A L P A L I V P I L E P E C L H I F V D L H S G M F Q L M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S S
S S
T T S S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence L Y G L D P A T L E D M E K S L N D D M K R I I P W I Q Q L K F W L G Q Q R C K Q S I K H L P T I T T E T L Q L A N Y S T H P I G S L S K N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
T T T S S T T S S S S
S
S
T T T T S
S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence K L F I K L T R L P Q Y Y I V V E M L E V P N K P T Q L S Y N Y Y F M S V S S P V M A L L L Q Q F K D N I Q D L M S Y T K T G C A F N K V L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
S S S S
S S
T T
S S
T T
T T T S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence A H F V A M C D T N M P F V G L R L E L S N L E I P H Q G V Q V E G D G F N H A I R L L K I P P C K G I S E E T Q K A L D R S L L D C T F R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S
B T T
S T T T S
S
S
S S
T T T

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence L Q G R N N R T W V A E L V F A N C P L N G T S T R E Q G P S R H V Y L T Y E N L L S K V V E M F L N D W S S I A R L Y E C V L E F A R S L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S S S
S S
S S
T T S
S S
S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence P E I P A H I F S E V R V Y N Y R K L I L C Y G T T K G S S I S I Q W N S I H Q K F H I A L G T V G P N S G C S N C H N T I L H Q L Q E M F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S G G G
S
S S S
T T S S
S
S S S S
S S S
S S
S
S S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence N K T P N V V Q L L Q V L F D T Q A P L N A I N K L P T V P M L G L T Q R T N T A Y Q C F S I L P Q S S T H I R L A F R N M Y C I D I Y C R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
S
S S
S S S S S
S S
B
S S S
B B
S S S S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence S R G V V A I R D G A Y S L F D N S K L V E G F Y P A P G L K T F L N M F V D S R S W A A S I P T I H S A L N I L L L P S P T P G L V P G L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S
S S S T T S S S S
S S S
S
S
T T
S S
B S
T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence A G S Y L C S P L E R F L G S V I M R R H L Q R I I Q Q E T L Q L I N S N E P G V I M F K T D A L K C R V A L S P K T N Q T L Q L K V T P E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
B
T S
S S
S S
S S T T T
S S

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence D E L Q V L E K F F E T R V A G P P F K A N T L I A F T K L L G A P T H I L R D C V H I M K L E L F P D Q L K W N V Q F C L T I P P S A P P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S
S
T T T S S
S
S S
T T S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence I A P P G T P A V V L K S K M L F F L Q L T Q K T V S I I V P I I Y D M A T Q Q A N S S V A A P M M V S N I L K R F A E M R Q G E C T I F A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
S
S S S
B
B
B
B B
B
T T
S S S S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050

Sequence A V R D L M A N X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S
S S

. . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . .

Sequence X X X X X X X X X X X X X X X X X X X X X X X X X X X

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	L	V	H	A	R	L	P	S	F	A	I	P	Y	A	I	D	V	L	Y	P	R	L	P	T	C	I	R	D	K	I	I	P	P	D	P	I	T	K	I	E	K	Q	A	T	L	H	Q	L	N	Q	I	L	R	H	R	L	V	T	T	D	L	P	P	Q	L	A	N	L	T	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S	S																S	T	T			S	S					S	S						T	T																			S			T	T	T	T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	A	N	G	R	V	K	F	R	V	E	G	E	F	E	A	T	L	T	V	M	E	V	P	W	R	L	L	K	L	E	I	L	V	R	A	L	V	H	S	M	Q	I	D	F	I	H	Q	L	V	Q	S	R	L	F	A	D	E	K	P	L	Q	D	M	Y	N	C	L	H	C	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	S	S						T	T	T	S		B															B						S				S												T	T	T	T		S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	C	L	S	L	Q	L	E	V	L	H	S	Q	T	L	M	L	I	R	E	R	W	G	D	L	V	Q	V	E	R	Y	H	A	G	K	S	L	S	L	S	V	W	N	Q	S	V	H	K	V	T	I	K	I	D	E	N	D	V	S	K	P	L	Q	I	F	H	D	P	P	L	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																			T	T		S	S	S	S							S	S	S																			T	T	S		S	S	S	S						S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	A	M	K	I	D	H	L	S	I	E	K	L	L	I	D	S	V	H	A	R	A	H	Q	R	L	Q	E	L	K	A	I	L	R	S	F	N	A	S	I	E	T	A	L	P	A	L	I	V	P	I	L	E	P	E	C	L	H	I	F	V	D	L	H	S	G	M	F	Q	L	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S	S																																				S	S						S	S											T	T	S	S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	L	Y	G	L	D	P	A	T	L	E	D	M	E	K	S	L	N	D	D	M	K	R	I	I	P	W	I	Q	Q	L	K	F	W	L	G	Q	Q	R	C	K	Q	S	I	K	H	L	P	T	I	T	T	E	T	L	Q	L	A	N	Y	S	T	H	P	I	G	S	L	S	K	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	S	S		T	T	T												S	S	T	T																					S	S	S	S					S			S			T	T	T	T	S					S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	K	L	F	I	K	L	T	R	L	P	Q	Y	Y	I	V	V	E	M	L	E	V	P	N	K	P	T	Q	L	S	Y	N	Y	Y	F	M	S	V	S	S	P	V	M	A	L	L	L	Q	Q	F	K	D	N	I	Q	D	L	M	S	Y	T	K	T	G	C	A	F	N	K	V	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S	S	S		S	S	S	S								S	S		T	T		S	S																				T	T				T	T	T								S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	A	H	F	V	A	M	C	D	T	N	M	P	F	V	G	L	R	L	E	L	S	N	L	E	I	P	H	Q	G	V	Q	V	E	G	D	G	F	N	H	A	I	R	L	L	K	I	P	P	C	K	G	I	S	E	E	T	Q	K	A	L	D	R	S	L	L	D	C	T	F	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																					T	T	T	S			B	T	T			S	T	T	T	S		S							S					S	S		T	T	T
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	L	Q	G	R	N	N	R	T	W	V	A	E	L	V	F	A	N	C	P	L	N	G	T	S	T	R	E	Q	G	P	S	R	H	V	Y	L	T	Y	E	N	L	L	S	K	V	V	E	M	F	L	N	D	W	S	S	I	A	R	L	Y	E	C	V	L	E	F	A	R	S	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S	S	S	S									S	S		S	S			T	T	S				S	S											S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	P	E	I	P	A	H	I	F	S	E	V	R	V	Y	N	Y	R	K	L	I	L	C	Y	G	T	T	K	G	S	S	I	S	I	Q	W	N	S	I	H	Q	K	F	H	I	A	L	G	T	V	G	P	N	S	G	C	S	N	C	H	N	T	I	L	H	Q	L	Q	E	M	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S	G	G	G							S			S	S	S						T	T	S	S			S								S	S	S	S											S	S	S		S	S		S			S	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	N	K	T	P	N	V	V	Q	L	L	Q	V	L	F	D	T	Q	A	P	L	N	A	I	N	K	L	P	T	V	P	M	L	G	L	T	Q	R	T	N	T	A	Y	Q	C	F	S	I	L	P	Q	S	S	T	H	I	R	L	A	F	R	N	M	Y	C	I	D	I	Y	C	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																								T	T	S			S				S	S		S	S	S	S	S				S	S			B			S	S	S			B	B		S	S	S	S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	S	R	G	V	V	A	I	R	D	G	A	Y	S	L	F	D	N	S	K	L	V	E	G	F	Y	P	A	P	G	L	K	T	F	L	N	M	F	V	D	S	R	S	W	A	A	S	I	P	T	I	H	S	A	L	N	I	L	L	L	P	S	P	T	P	G	L	V	P	G	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S	S							S	S	S	T	T	S	S	S	S				S	S	S		S			S								T	T																				S	S		B	S			T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	A	G	S	Y	L	C	S	P	L	E	R	F	L	G	S	V	I	M	R	R	H	L	Q	R	I	I	Q	Q	E	T	L	Q	L	I	N	S	N	E	P	G	V	I	M	F	K	T	D	A	L	K	C	R	V	A	L	S	P	K	T	N	Q	T	L	Q	L	K	V	T	P	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S					B																							T	S							S	S							S	S								S	S	T	T	T									S	S
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	D	E	L	Q	V	L	E	K	F	F	E	T	R	V	A	G	P	P	F	K	A	N	T	L	I	A	F	T	K	L	L	G	A	P	T	H	I	L	R	D	C	V	H	I	M	K	L	E	L	F	P	D	Q	L	K	W	N	V	Q	F	C	L	T	I	P	P	S	A	P	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																S	S		S		S													T	T	T												S	S						S								S	S		T	T	S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	I	A	P	P	G	T	P	A	V	V	L	K	S	K	M	L	F	F	L	Q	L	T	Q	K	T	V	S	I	I	V	P	I	I	Y	D	M	A	T	Q	Q	A	N	S	S	V	A	A	P	M	M	V	S	N	I	L	K	R	F	A	E	M	R	Q	G	E	C	T	I	F	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S				S	S		S				S	S	S		B				B										B			B	B					B																			T	T					S	S	S	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050
Sequence	A	V	R	D	L	M	A	N	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T					S		S	S
	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.
Sequence	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	S			T	T