PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c6nr7A_

Fold library id	PDB Header	Molecule	Title
c6nr7A_	3.00	PDB header: cell adhesion	Chain: A: PDB Molecule: vinculin;

Links to external resources
Added to library: Sat Feb 1 08:43:02 2020

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence M G S S H H H H H H S S G L V P R G S H M P V F H T R T I E S I L E P V A Q Q I S H L V I M H E E G E V D G K A I P D L T A P V S A V Q A A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S T T T
S S
S
B T T T T T S S
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence V S N L V R V G K E T V Q T T E D Q I L K R D M P P A F I K V E N A C T K L V R A A Q M L Q A D P Y S V P A R D Y L I D G S R G I L S G T S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S S
T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence D L L L T F D E A E V R K I I R V C K G I L E Y L T V A E V V E T M E D L V T Y T K N L G P G M T K M A K M I D E R Q Q E L T H Q E H R V M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T
T T B S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence L V N S M N T V K E L L P V L I S A M K I F V T T K N T K S Q G I E E A L K N R N F T V E K M S A E I N E I I R V L Q L T S W D E D A W A S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
S S S
S S
T
S
S S T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence K D T E A M K R A L A L I D S K M N Q A K G W L R D P N A P P G D A G E Q A I R Q I L D E A G K A G E L C A G K E R R E I L G T C K T L G Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S G G G T
S
S S S S S T
T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence M T D Q L A D L R A R G Q G A T P M A M Q K A Q Q V S Q G L D L L T A K V E N A A R K L E A M T N S K Q A I A K K I D A A Q N W L A D P N G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T
S S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence G S E G E E H I R G I M S E A R K V A E L C E E P K E R D D I L R S L G E I S A L T A K L S D L R R H G K G D S P E A R A L A K Q I A T S L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S T T T S
T T T T S S T T T T

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence Q N L Q S K T N R A V A N T R P V K A A V H L E G K I E Q A Q R W I D N P T V D D R G V G Q A A I R G L V A E G R R L A N V M M G P Y R Q D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S
S S T T S S
S
T T T T T T T S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence L L A K C D R V D Q L A A Q L A D L A A R G E G E S P Q A R A I A A Q L Q D S L K D L K A R M Q E A M T Q E V S D V F S D T T T P I K L L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T T T S
S S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence V A A T A P S D T P N R E E V F E E R A A N F E N H A A R L G A T A E K A A A V G T A N K T T V E G I Q A T V K S A R E L T P Q V V S A A R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence I L L R N P G N Q A A Y E H F E T M K N Q W I D N V E K M T G L V D E A I D T K S L L D A S E E A I K K D L D K C K V A M A N M Q P Q M L V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S T T S
T T T
S

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence A G A T S I A R R A N R I L L V A K R E V E N S E D P K F R E A V K A A S D E L S K T I S P M V M D A K A V A G N I S D P G L Q K S F L D S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S B
S T T G G G S T T T T T T S S
T T T

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence G Y R I L G A V A K V R E A F Q P Q E P D F P P P P P D L E H L H L T D E L A P P K P P L P E G E V P P P R P P P P E E K D E E F P E Q K A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
S
S S S
S
S
S
S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence G E A I N Q P M M M A A R Q L H D E A R K W S S K G N D I I A A A K R M A L L M A E M S R L V R G G S G N K R A L I Q C A K D I A K A S D E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T B
S S
T T S S
S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050

Sequence V T R L A K E V A K Q C T D K R I R T N L L Q V C E R I P T I S T Q L K I L S T V K A T M L G R T N I S D E E S E Q A T E M L V H N A Q N L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T B
B S T T S S
T T

. . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080 . . . . . .

Sequence M Q S V K E T V R E A E A A S I K I R T D A G F T L R W V R K T P W Y Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S B
T T
B
S S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: The Phyre2 web portal for protein modeling, prediction and analysis

Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

© Structural Bioinformatics Group,
Imperial College,
London
Michael Sternberg
Disclaimer

Terms and Conditions

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	M	G	S	S	H	H	H	H	H	H	S	S	G	L	V	P	R	G	S	H	M	P	V	F	H	T	R	T	I	E	S	I	L	E	P	V	A	Q	Q	I	S	H	L	V	I	M	H	E	E	G	E	V	D	G	K	A	I	P	D	L	T	A	P	V	S	A	V	Q	A	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S	S	S	T	T	T						S	S		S							B																					T	T	T	T	T	S	S								T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	V	S	N	L	V	R	V	G	K	E	T	V	Q	T	T	E	D	Q	I	L	K	R	D	M	P	P	A	F	I	K	V	E	N	A	C	T	K	L	V	R	A	A	Q	M	L	Q	A	D	P	Y	S	V	P	A	R	D	Y	L	I	D	G	S	R	G	I	L	S	G	T	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T	S																																		S	S							T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	D	L	L	L	T	F	D	E	A	E	V	R	K	I	I	R	V	C	K	G	I	L	E	Y	L	T	V	A	E	V	V	E	T	M	E	D	L	V	T	Y	T	K	N	L	G	P	G	M	T	K	M	A	K	M	I	D	E	R	Q	Q	E	L	T	H	Q	E	H	R	V	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																											T	T	T	T															T																T	B	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	L	V	N	S	M	N	T	V	K	E	L	L	P	V	L	I	S	A	M	K	I	F	V	T	T	K	N	T	K	S	Q	G	I	E	E	A	L	K	N	R	N	F	T	V	E	K	M	S	A	E	I	N	E	I	I	R	V	L	Q	L	T	S	W	D	E	D	A	W	A	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											T													S			S	S	S		S	S																											T			S			S	S	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	K	D	T	E	A	M	K	R	A	L	A	L	I	D	S	K	M	N	Q	A	K	G	W	L	R	D	P	N	A	P	P	G	D	A	G	E	Q	A	I	R	Q	I	L	D	E	A	G	K	A	G	E	L	C	A	G	K	E	R	R	E	I	L	G	T	C	K	T	L	G	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																	S	G	G	G	T							S				S	S	S	S	S																T			T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	M	T	D	Q	L	A	D	L	R	A	R	G	Q	G	A	T	P	M	A	M	Q	K	A	Q	Q	V	S	Q	G	L	D	L	L	T	A	K	V	E	N	A	A	R	K	L	E	A	M	T	N	S	K	Q	A	I	A	K	K	I	D	A	A	Q	N	W	L	A	D	P	N	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											T	T		T	T																																																				S	S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	G	S	E	G	E	E	H	I	R	G	I	M	S	E	A	R	K	V	A	E	L	C	E	E	P	K	E	R	D	D	I	L	R	S	L	G	E	I	S	A	L	T	A	K	L	S	D	L	R	R	H	G	K	G	D	S	P	E	A	R	A	L	A	K	Q	I	A	T	S	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	T	T	T																S																														T	T	T	T	S	S	T	T	T	T
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	Q	N	L	Q	S	K	T	N	R	A	V	A	N	T	R	P	V	K	A	A	V	H	L	E	G	K	I	E	Q	A	Q	R	W	I	D	N	P	T	V	D	D	R	G	V	G	Q	A	A	I	R	G	L	V	A	E	G	R	R	L	A	N	V	M	M	G	P	Y	R	Q	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T	S		S				S	S										T	T	S	S		S		T	T	T	T	T																		T	T	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	L	L	A	K	C	D	R	V	D	Q	L	A	A	Q	L	A	D	L	A	A	R	G	E	G	E	S	P	Q	A	R	A	I	A	A	Q	L	Q	D	S	L	K	D	L	K	A	R	M	Q	E	A	M	T	Q	E	V	S	D	V	F	S	D	T	T	T	P	I	K	L	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																						S								T	T																												T	S		S	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	V	A	A	T	A	P	S	D	T	P	N	R	E	E	V	F	E	E	R	A	A	N	F	E	N	H	A	A	R	L	G	A	T	A	E	K	A	A	A	V	G	T	A	N	K	T	T	V	E	G	I	Q	A	T	V	K	S	A	R	E	L	T	P	Q	V	V	S	A	A	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S	S			T	T																														S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	I	L	L	R	N	P	G	N	Q	A	A	Y	E	H	F	E	T	M	K	N	Q	W	I	D	N	V	E	K	M	T	G	L	V	D	E	A	I	D	T	K	S	L	L	D	A	S	E	E	A	I	K	K	D	L	D	K	C	K	V	A	M	A	N	M	Q	P	Q	M	L	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T		S																										T	T	S																									T	T	T		S
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	A	G	A	T	S	I	A	R	R	A	N	R	I	L	L	V	A	K	R	E	V	E	N	S	E	D	P	K	F	R	E	A	V	K	A	A	S	D	E	L	S	K	T	I	S	P	M	V	M	D	A	K	A	V	A	G	N	I	S	D	P	G	L	Q	K	S	F	L	D	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	S	S																				B																		S	T	T	G	G	G	S	T	T	T	T	T	T	S	S				T					T	T
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	G	Y	R	I	L	G	A	V	A	K	V	R	E	A	F	Q	P	Q	E	P	D	F	P	P	P	P	P	D	L	E	H	L	H	L	T	D	E	L	A	P	P	K	P	P	L	P	E	G	E	V	P	P	P	R	P	P	P	P	E	E	K	D	E	E	F	P	E	Q	K	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																S		S	S			S																						S	S	S					S					S			S											S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	G	E	A	I	N	Q	P	M	M	M	A	A	R	Q	L	H	D	E	A	R	K	W	S	S	K	G	N	D	I	I	A	A	A	K	R	M	A	L	L	M	A	E	M	S	R	L	V	R	G	G	S	G	N	K	R	A	L	I	Q	C	A	K	D	I	A	K	A	S	D	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S																				T	B			S	S																				T	T	S	S			S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050
Sequence	V	T	R	L	A	K	E	V	A	K	Q	C	T	D	K	R	I	R	T	N	L	L	Q	V	C	E	R	I	P	T	I	S	T	Q	L	K	I	L	S	T	V	K	A	T	M	L	G	R	T	N	I	S	D	E	E	S	E	Q	A	T	E	M	L	V	H	N	A	Q	N	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										T	T	B		B												S																		T	T	S	S			T	T
	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.	.	.	.	.
Sequence	M	Q	S	V	K	E	T	V	R	E	A	E	A	A	S	I	K	I	R	T	D	A	G	F	T	L	R	W	V	R	K	T	P	W	Y	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																	S	B		T	T									B			S	S