PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c6m0wA_

Fold library id	PDB Header	Molecule	Title
c6m0wA_	2.76	PDB header: hydrolase/dna/rna	Chain: A: PDB Molecule: crispr-associated endonuclease cas9 1;

Links to external resources
Added to library: Sat Sep 12 08:55:14 2020

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence M G S D L V L G L D I G I G S V G V G I L N K V T G E I I H K N S R I F P A A Q A E N N L V R R T N R Q G R R L A R R K K H R R V R L N R L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S S T T T
G G G T T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence F E E S G L I T D F T K I S I N L N P Y Q L R V K G L T D E L S N E E L F I A L K N M V K H R G I S Y K T P G Q I Q L E R Y Q T Y G Q L R G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S
S S
S
S
T T T S
B
S
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence D F T V E K D G K K H R L I N V F P T S A Y R S E A L R I L Q T Q Q E F N P Q I T D E F I N R Y L E I L T G K R K Y Y H G P G N E K S R T D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
B
S S
T T T
S
S S S
T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence Y G R Y R T S G E T L D N I F G I L I G K C T F Y P D E F R A A K A S Y T A Q E F N L L N D L N N L T V P T E T K K L S K E Q K N Q I I N Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S B
T T S
B
S
T T G G G S
B
S S S T T S B
B T T S T T
B
S S T T S S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence V K N E K A M G P A K L F K Y I A K L L D V A D I K G Y R I D K S G K A E I H T F E A Y R K M K T L E T L D I E Q M D R E T L D K L A Y V L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T T
G G G
B
B
S S S
B
T T
S S S
S S S S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence T L N T E R E G I Q E A L E H E F A D G S F S Q K Q V D E L V Q F R K A N S S I F G K G W H N F S V K L M M E L I P E L Y E T S E E Q M T I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T S
T T T S
B
S S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence L T R L G Y I D E K L L T E E I Y N P V V A K S V R Q A I K I V N A A I K E Y G D F D N I V I E M A R E T N E D D E K K A I Q K I Q K A N K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence D E K D A A M L K A A N Q Y N G K A E L P H S V F H G H K Q L A T K I R L W H Q Q G E R C L Y T G K T I S I H D L I N N S N Q F E V D A I L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S S S
G G G G T T
T T T T T B
T T T
B
S G G G S S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence P L S I T F D D S L A N K V L V Y A T A N Q E K G Q R T P Y Q A L D S M D D A W S F R E L K A F V R E S K T L S N K K K E Y L L T E E D I S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S G G G
S S
T T T
S S S
S S S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence K F D V I E R N L V D T R Y A S R V V L N A L Q E H F R A H K I D T K V S V V R G Q F T S Q L R R H W G I E K T R D T Y H H H A V D A L I I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T
S S
T T S T

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence A A S S Q L N L A P Y Q H F V D T L K S K E F E D S I L F S Y Q V D S K F N R K I S D A T I Y A T R Q A K V G K D K A D E T Y V L G K I K D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G
T
T T
B
S
S
S
S S
S S
S

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence I Y T Q D G Y D A F M K I Y K K D K S K F L M Y R H D P Q T F E K V I E P I L E N Y P N K V P C N P F L K Y K E E H G Y I R K Y S K K G N G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S G G G B
T S
S S
B
S S S

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence P E I K S L K Y Y D S K L G N H I D I T P K D S N N K V V L Q S V S P W R A D V Y F N K T T G K Y E I L G L K Y A D L Q F E K G T G T Y K I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
S
T T
S S
S
T T T
G G G
T T T

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence S Q E K Y N D I K K K E G V D S D S E F K F T L Y K N D L L L V K D T E T K E Q Q L F R F L S R T M P K Q K H Y V E L K P Y D K Q K F E G G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T S B T
S S S S
T T S T T
S S S S
S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . .

Sequence E A L I K V L G N V A N S G Q C K K G L G K S N I S I Y K V R T D V L G N Q H I I K N E G D K P K L D F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
S
T T S
S S
T T
S
S S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: The Phyre2 web portal for protein modeling, prediction and analysis

Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

© Structural Bioinformatics Group,
Imperial College,
London
Michael Sternberg
Disclaimer

Terms and Conditions

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	M	G	S	D	L	V	L	G	L	D	I	G	I	G	S	V	G	V	G	I	L	N	K	V	T	G	E	I	I	H	K	N	S	R	I	F	P	A	A	Q	A	E	N	N	L	V	R	R	T	N	R	Q	G	R	R	L	A	R	R	K	K	H	R	R	V	R	L	N	R	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S									S	S									T	T	T													G	G	G	T	T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	F	E	E	S	G	L	I	T	D	F	T	K	I	S	I	N	L	N	P	Y	Q	L	R	V	K	G	L	T	D	E	L	S	N	E	E	L	F	I	A	L	K	N	M	V	K	H	R	G	I	S	Y	K	T	P	G	Q	I	Q	L	E	R	Y	Q	T	Y	G	Q	L	R	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	S		S			S	S			S		S									T	T	T	S																				B																	S			S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	D	F	T	V	E	K	D	G	K	K	H	R	L	I	N	V	F	P	T	S	A	Y	R	S	E	A	L	R	I	L	Q	T	Q	Q	E	F	N	P	Q	I	T	D	E	F	I	N	R	Y	L	E	I	L	T	G	K	R	K	Y	Y	H	G	P	G	N	E	K	S	R	T	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T							S			B																				S	S																			T	T	T		S			S	S	S			T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	Y	G	R	Y	R	T	S	G	E	T	L	D	N	I	F	G	I	L	I	G	K	C	T	F	Y	P	D	E	F	R	A	A	K	A	S	Y	T	A	Q	E	F	N	L	L	N	D	L	N	N	L	T	V	P	T	E	T	K	K	L	S	K	E	Q	K	N	Q	I	I	N	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S	S	B		T	T	S		B		S		T	T	G	G	G	S		B		S	S	S	T	T	S	B			B	T	T	S													T	T		B		S	S	T	T	S	S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	V	K	N	E	K	A	M	G	P	A	K	L	F	K	Y	I	A	K	L	L	D	V	A	D	I	K	G	Y	R	I	D	K	S	G	K	A	E	I	H	T	F	E	A	Y	R	K	M	K	T	L	E	T	L	D	I	E	Q	M	D	R	E	T	L	D	K	L	A	Y	V	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S	S											T	T	T			G	G	G		B			B			S	S	S			B											T	T		S	S	S		S	S	S	S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	T	L	N	T	E	R	E	G	I	Q	E	A	L	E	H	E	F	A	D	G	S	F	S	Q	K	Q	V	D	E	L	V	Q	F	R	K	A	N	S	S	I	F	G	K	G	W	H	N	F	S	V	K	L	M	M	E	L	I	P	E	L	Y	E	T	S	E	E	Q	M	T	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S												S		T	T	S															T	T					T	S		B		S	S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	L	T	R	L	G	Y	I	D	E	K	L	L	T	E	E	I	Y	N	P	V	V	A	K	S	V	R	Q	A	I	K	I	V	N	A	A	I	K	E	Y	G	D	F	D	N	I	V	I	E	M	A	R	E	T	N	E	D	D	E	K	K	A	I	Q	K	I	Q	K	A	N	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T	T																												S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	D	E	K	D	A	A	M	L	K	A	A	N	Q	Y	N	G	K	A	E	L	P	H	S	V	F	H	G	H	K	Q	L	A	T	K	I	R	L	W	H	Q	Q	G	E	R	C	L	Y	T	G	K	T	I	S	I	H	D	L	I	N	N	S	N	Q	F	E	V	D	A	I	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)															T	S	S	S	S			G	G	G	G	T	T		T	T											T	T	T	B		T	T	T			B									S	G	G	G						S	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	P	L	S	I	T	F	D	D	S	L	A	N	K	V	L	V	Y	A	T	A	N	Q	E	K	G	Q	R	T	P	Y	Q	A	L	D	S	M	D	D	A	W	S	F	R	E	L	K	A	F	V	R	E	S	K	T	L	S	N	K	K	K	E	Y	L	L	T	E	E	D	I	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	G	G	G														S	S						T	T	T		S	S	S														S	S	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	K	F	D	V	I	E	R	N	L	V	D	T	R	Y	A	S	R	V	V	L	N	A	L	Q	E	H	F	R	A	H	K	I	D	T	K	V	S	V	V	R	G	Q	F	T	S	Q	L	R	R	H	W	G	I	E	K	T	R	D	T	Y	H	H	H	A	V	D	A	L	I	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T																												T																					S	S					T	T	S	T
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	A	A	S	S	Q	L	N	L	A	P	Y	Q	H	F	V	D	T	L	K	S	K	E	F	E	D	S	I	L	F	S	Y	Q	V	D	S	K	F	N	R	K	I	S	D	A	T	I	Y	A	T	R	Q	A	K	V	G	K	D	K	A	D	E	T	Y	V	L	G	K	I	K	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					G	G	G												T						T	T								B				S				S		S											S	S		S	S										S
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	I	Y	T	Q	D	G	Y	D	A	F	M	K	I	Y	K	K	D	K	S	K	F	L	M	Y	R	H	D	P	Q	T	F	E	K	V	I	E	P	I	L	E	N	Y	P	N	K	V	P	C	N	P	F	L	K	Y	K	E	E	H	G	Y	I	R	K	Y	S	K	K	G	N	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	S															G	G	G	B													T								S																	S	S		B				S	S	S
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	P	E	I	K	S	L	K	Y	Y	D	S	K	L	G	N	H	I	D	I	T	P	K	D	S	N	N	K	V	V	L	Q	S	V	S	P	W	R	A	D	V	Y	F	N	K	T	T	G	K	Y	E	I	L	G	L	K	Y	A	D	L	Q	F	E	K	G	T	G	T	Y	K	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		B													S							T	T		S	S						S												T	T	T										G	G	G					T	T	T
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	S	Q	E	K	Y	N	D	I	K	K	K	E	G	V	D	S	D	S	E	F	K	F	T	L	Y	K	N	D	L	L	L	V	K	D	T	E	T	K	E	Q	Q	L	F	R	F	L	S	R	T	M	P	K	Q	K	H	Y	V	E	L	K	P	Y	D	K	Q	K	F	E	G	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T			T	T	S								B	T								S	S	S	S													T	T	S	T	T							S	S	S	S				S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.
Sequence	E	A	L	I	K	V	L	G	N	V	A	N	S	G	Q	C	K	K	G	L	G	K	S	N	I	S	I	Y	K	V	R	T	D	V	L	G	N	Q	H	I	I	K	N	E	G	D	K	P	K	L	D	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T	T		S			T	T	S									S	S										T	T							S				S	S