PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c6jdvA_

Fold library id	PDB Header	Molecule	Title
c6jdvA_	3.10	PDB header: hydrolase/rna/dna	Chain: A: PDB Molecule: crispr-associated endonuclease cas9;

Links to external resources
Added to library: Sat Nov 9 08:35:56 2019

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence S I N Y I L G L D I G I A S V G W A M V E I D E E E N P I R L I D L G V R V F E R A E D S L A M A R R L A R S V R R L T R R R A H R L L R T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence R R L L K R E G V L Q A A N F D E N G L I K S L P N T P W Q L R A A A L D R K L T P L E W S A V L L H L I K H R G Y L S Q R K N D F R T P A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S
S S S B
T T S
B T T
S
T T T S
S
B
S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence E L A L N K F E K E S G H I R N Q R S D Y S H T F S R K D L Q A E L I L L F E K Q K E F G N P H V S G G L K E G I E T L L M T Q R P A L S G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
S S
S S
B T
S
S S
T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence D A V Q K M L G H C T F E P A E P K A A K N T Y T A E R F I W L T K L N N L R I L E Q G S E R P L T D T E R A T L M D E P Y R K S K L T Y A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
B
S S
T T S B
B S S S T
S S
T S S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence Q A R K L L G L E D T A F F K G L R Y G K D N A E A S T L M E M K A Y H A I S R A L E K E G L K D K K S P L N L S P E L Q D E I G T A F S L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S S
S S
S S S
G G G S
S
T T S S
S S S
S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence F K T D E D I T G R L K D R I Q P E I L E A L L K H I S F D K F V Q I S L K A L R R I V P L M E Q G K R Y D E A C A E I Y G D H Y G K K N T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S T T T S
B
S S
T T
S
T T

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence E E K I Y L P P I P A D E I R N P V V L R A L S Q A R K V I N G V V R R Y G S P A R I H I E T A R E V G K S F K D R K E I E K R Q E E N R K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B S S
S S S
S S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence D R E K A A A K F R E Y F P N F V G E P K S K D I L K L R L Y E Q Q H G K C L Y S G K E I N L G R L N E K G Y V E I D A A L P F S R T W D D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S
T T S B
T T T
B
T T
S S S T T T S S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence S F N N K V L V L G S E N Q N K G N Q T P Y E Y F N G K D N S R E W Q E F K A R V E T S R F P R S K K Q R I L L Q K F D R N L N D T R Y V N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S G G G T T
T T T T T
T S S
S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence R F L C Q F V A D R M R L T G K G K K R V F A S N G Q I T N L L R G F W G L R K V R A E N D R H H A L D A V V V A C S T V A M Q Q K I T R F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) B
S S S
T T
S S
T T

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence V R Y K E M N A F D G K T I D T G E V L H Q K T H F P Q P W E F F A Q E V M I R V F G K P D G K P E F E E A D T L E K L R T L L A E K L S S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T T T
T T S
S S T T S S
S S
S
S
S S
S

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence R P E A V H E Y V T P L F V S R A P N R K M S G Q G H M E T V K S A K R L D E G V S V L R V P L T Q L K L K D L E K M V N R E R E P K L Y E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S S S T T
B
S
T T T T T T G G G
T T B G G G T T S

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence A L K A R L E A H K D D P A K A F A E P F Y K Y D K A G N R T Q Q V K A V R V E Q V Q K T G V W V R N H N G I A D N A T M V R V D V F E K G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
T S S
T T S
S
S
T T T T
B
T

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence D K Y Y L V P I Y S W Q V A K G I L P D R A V V Q G K D E E D W Q L I D D S F N F K F S L H P N D L V E V I T K K A R M F G Y F A S C H R G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S S S
G G G S
T T S
T T
T T
T T

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . .

Sequence T G N I N I R I H D L D H K I G K N G I L E G I G V K T A L S F Q K Y Q I D E L G K E I R P C R L K K R P P V R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
T T
T T T T B T T
S S
S
S S S
S S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	S	I	N	Y	I	L	G	L	D	I	G	I	A	S	V	G	W	A	M	V	E	I	D	E	E	E	N	P	I	R	L	I	D	L	G	V	R	V	F	E	R	A	E	D	S	L	A	M	A	R	R	L	A	R	S	V	R	R	L	T	R	R	R	A	H	R	L	L	R	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												S	S											T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	R	R	L	L	K	R	E	G	V	L	Q	A	A	N	F	D	E	N	G	L	I	K	S	L	P	N	T	P	W	Q	L	R	A	A	A	L	D	R	K	L	T	P	L	E	W	S	A	V	L	L	H	L	I	K	H	R	G	Y	L	S	Q	R	K	N	D	F	R	T	P	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	S	S		S	S	S	B		T	T	S		B	T	T			S									T	T	T	S																	S			B				S					S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	E	L	A	L	N	K	F	E	K	E	S	G	H	I	R	N	Q	R	S	D	Y	S	H	T	F	S	R	K	D	L	Q	A	E	L	I	L	L	F	E	K	Q	K	E	F	G	N	P	H	V	S	G	G	L	K	E	G	I	E	T	L	L	M	T	Q	R	P	A	L	S	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											T	S		S	S			S	S							B																		T			S																				S	S		T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	D	A	V	Q	K	M	L	G	H	C	T	F	E	P	A	E	P	K	A	A	K	N	T	Y	T	A	E	R	F	I	W	L	T	K	L	N	N	L	R	I	L	E	Q	G	S	E	R	P	L	T	D	T	E	R	A	T	L	M	D	E	P	Y	R	K	S	K	L	T	Y	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T								B		S	S		T	T	S	B			B	S	S	S														T						S	S															T					S	S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	Q	A	R	K	L	L	G	L	E	D	T	A	F	F	K	G	L	R	Y	G	K	D	N	A	E	A	S	T	L	M	E	M	K	A	Y	H	A	I	S	R	A	L	E	K	E	G	L	K	D	K	K	S	P	L	N	L	S	P	E	L	Q	D	E	I	G	T	A	F	S	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T				S	S				S	S				S	S	S		G	G	G	S		S																T	T	S	S		S	S	S				S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	F	K	T	D	E	D	I	T	G	R	L	K	D	R	I	Q	P	E	I	L	E	A	L	L	K	H	I	S	F	D	K	F	V	Q	I	S	L	K	A	L	R	R	I	V	P	L	M	E	Q	G	K	R	Y	D	E	A	C	A	E	I	Y	G	D	H	Y	G	K	K	N	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S									T	T	T	S																	B		S	S														T	T												S		T	T
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	E	E	K	I	Y	L	P	P	I	P	A	D	E	I	R	N	P	V	V	L	R	A	L	S	Q	A	R	K	V	I	N	G	V	V	R	R	Y	G	S	P	A	R	I	H	I	E	T	A	R	E	V	G	K	S	F	K	D	R	K	E	I	E	K	R	Q	E	E	N	R	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			B	S	S						S	S	S																												S							S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	D	R	E	K	A	A	A	K	F	R	E	Y	F	P	N	F	V	G	E	P	K	S	K	D	I	L	K	L	R	L	Y	E	Q	Q	H	G	K	C	L	Y	S	G	K	E	I	N	L	G	R	L	N	E	K	G	Y	V	E	I	D	A	A	L	P	F	S	R	T	W	D	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														T	T		S	S																T	T	S	B		T	T	T			B			T	T		S	S	S	T	T	T						S	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	S	F	N	N	K	V	L	V	L	G	S	E	N	Q	N	K	G	N	Q	T	P	Y	E	Y	F	N	G	K	D	N	S	R	E	W	Q	E	F	K	A	R	V	E	T	S	R	F	P	R	S	K	K	Q	R	I	L	L	Q	K	F	D	R	N	L	N	D	T	R	Y	V	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	G	G	G													T	T								T	T	T	T	T													T	S	S										S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	R	F	L	C	Q	F	V	A	D	R	M	R	L	T	G	K	G	K	K	R	V	F	A	S	N	G	Q	I	T	N	L	L	R	G	F	W	G	L	R	K	V	R	A	E	N	D	R	H	H	A	L	D	A	V	V	V	A	C	S	T	V	A	M	Q	Q	K	I	T	R	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											B					S	S	S																		T	T				S	S				T	T
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	V	R	Y	K	E	M	N	A	F	D	G	K	T	I	D	T	G	E	V	L	H	Q	K	T	H	F	P	Q	P	W	E	F	F	A	Q	E	V	M	I	R	V	F	G	K	P	D	G	K	P	E	F	E	E	A	D	T	L	E	K	L	R	T	L	L	A	E	K	L	S	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S				T	T	T														T	T	S			S	S	T	T											S	S		S	S		S		S					S												S		S
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	R	P	E	A	V	H	E	Y	V	T	P	L	F	V	S	R	A	P	N	R	K	M	S	G	Q	G	H	M	E	T	V	K	S	A	K	R	L	D	E	G	V	S	V	L	R	V	P	L	T	Q	L	K	L	K	D	L	E	K	M	V	N	R	E	R	E	P	K	L	Y	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T	S	S	S	T	T																			B		S						T	T	T	T	T	T								G	G	G							T	T	B	G	G	G	T	T	S
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	A	L	K	A	R	L	E	A	H	K	D	D	P	A	K	A	F	A	E	P	F	Y	K	Y	D	K	A	G	N	R	T	Q	Q	V	K	A	V	R	V	E	Q	V	Q	K	T	G	V	W	V	R	N	H	N	G	I	A	D	N	A	T	M	V	R	V	D	V	F	E	K	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									T	T	T						T	S	S							T	T	S							S									S						T	T	T	T					B												T
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	D	K	Y	Y	L	V	P	I	Y	S	W	Q	V	A	K	G	I	L	P	D	R	A	V	V	Q	G	K	D	E	E	D	W	Q	L	I	D	D	S	F	N	F	K	F	S	L	H	P	N	D	L	V	E	V	I	T	K	K	A	R	M	F	G	Y	F	A	S	C	H	R	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T															T									S	S	S		G	G	G	S					T	T	S								T	T								T	T												T	T
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.
Sequence	T	G	N	I	N	I	R	I	H	D	L	D	H	K	I	G	K	N	G	I	L	E	G	I	G	V	K	T	A	L	S	F	Q	K	Y	Q	I	D	E	L	G	K	E	I	R	P	C	R	L	K	K	R	P	P	V	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T								T	T			T	T	T	T	B	T	T								S	S		S									S	S	S									S	S