PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c6dtdA_

Fold library id	PDB Header	Molecule	Title
c6dtdA_	1.65	PDB header: hydrolase/rna	Chain: A: PDB Molecule: nuclease;

Links to external resources
Added to library: Sat Feb 23 08:25:21 2019

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence Y Y E L T D K H F W A A F L N L A R H N V Y T T I N H I N R R L E I A E L K D D G Y M M G I K G S W N E Q A K K L D K K V R L R D L I M K H

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T
S S G G G G G G S
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence F P F L E A A A Y E M T N N N K E Q R E K E Q S E A L S L N N L K N V L F I F L E K L Q V L R N Y Y S H Y K Y S E E S P K P I F E T S L L K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T S T S S S T T S S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence N M Y K V F D A N V R L V K R D Y M H H E N I D M Q R D F T H L N R K K I D S P N F H Y H F A D K E G N M T I A G L L F F V S L F L D K K D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
T T
T T T T T G G G
T T
S B
T T S
B
T T S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence A I W M Q K K L K G F K D G R N L R E Q M T N E V F C R S R I S L P K L K L E N V Q T K D W M Q L D M L N E L V R C P K S L Y E R L R E K D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S T T T S
S T T S S
S B
T T S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence R E S F K V P F D I F E P F K N T L V R H Q D R F P Y F V L R Y F D L N E I F E Q L R F Q I D L G T Y H F S I Y N K R I G D E D E V R H L T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G S S
B
S
T T
S S T T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence H H L Y G F A R I Q D F A P Q N Q P E E W R K L V K T S Q E P Y I S K T A P H Y H L E N E K I G I K F C S A H N N L F P S L Q T D K T C N G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
G G G G
G G G
B
S S
B T T
S S
S
T T S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence R S K F N L G T Q F T A E A F L S V H E L L P M M F Y Y L L L T K D Y S R K E S A D K V E G I I R K E I S N I Y A I Y D A F A N N E I N S I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G S
S G G G T T T S
T T
S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence A D L T R R L Q N T N I L Q G H L P K Q M I S I L K G R Q K D M G K E A E R K I G E M I D D T Q R R L D L L C K Q T N Q K I R I G K R N A G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S
G G G S
T
S S
T T S T T
S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence L L K S G K I A D W L V N D M M R F Q P V Q K D Q N N I P I N N S K A N S T E Y R M L Q R A L A L F G S E N F R L K A Y F N Q M N L V G N D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
B
T T S
B
G G G S
T G G G T T S S S S S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence N P H P F L A E T Q W E H Q T N I L S F Y R N Y L E A R K K Y L K G L K P Q N W K Q Y Q H F L I L K V Q K T N R N T L V T G W K N S F N L P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S G G G T T G G G
S T
G G G
T T T
B

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence R G I F T Q P I R E W F E K H N N S K R I Y D Q I L S F D R V G F V A K A I P L Y F A E E Y K D N V Q P F Y D Y P F N I G N R L K P K K R Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T T
T T
T T T
S T T S
G G G G S
S
T T
G G G

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence F L D K K E R V E L W Q K N K E L F K N Y P S E K K K T D L A Y L D F L S W K K F E R E L R L I K N Q D I V T W L M F K E L F N M A G E I H

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence L R D I D T N T A N E E S N N I L N R I M P M K L P V K T Y E T D N K G N I L K E R P L A T F Y I E E T E T K V L K Q G N F K A L V K D R R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G
S
T T S G G G
T T S
G G G
T
T

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence L N G L F S F A E T T D L N L E E H P I S K L S V D L E L I K Y Q T T R I S I F E M T L G L E K K L I D K Y S T L P T D S F R N M L E R W L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G
T T
G G G S
T T S
S S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050

Sequence Q C K A N R P E L K N Y V N S L I A V R N A F S H N Q Y P M Y D A T L F A E V K K F T L F P K K I E L N I A P Q L L E I V G K A I K E I E K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
G G G T T
T T T T T T S
S

. . .

Sequence S E N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	Y	Y	E	L	T	D	K	H	F	W	A	A	F	L	N	L	A	R	H	N	V	Y	T	T	I	N	H	I	N	R	R	L	E	I	A	E	L	K	D	D	G	Y	M	M	G	I	K	G	S	W	N	E	Q	A	K	K	L	D	K	K	V	R	L	R	D	L	I	M	K	H
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T																											T	T					S	S	G	G	G	G	G	G								S			S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	F	P	F	L	E	A	A	A	Y	E	M	T	N	N	N	K	E	Q	R	E	K	E	Q	S	E	A	L	S	L	N	N	L	K	N	V	L	F	I	F	L	E	K	L	Q	V	L	R	N	Y	Y	S	H	Y	K	Y	S	E	E	S	P	K	P	I	F	E	T	S	L	L	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T																							T	T	S																							T	S	S	S	T	T	S	S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	N	M	Y	K	V	F	D	A	N	V	R	L	V	K	R	D	Y	M	H	H	E	N	I	D	M	Q	R	D	F	T	H	L	N	R	K	K	I	D	S	P	N	F	H	Y	H	F	A	D	K	E	G	N	M	T	I	A	G	L	L	F	F	V	S	L	F	L	D	K	K	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																	T	T	T		T	T			T	T	T	T	T	G	G	G								T	T					S	B		T	T	S		B											T	T	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	A	I	W	M	Q	K	K	L	K	G	F	K	D	G	R	N	L	R	E	Q	M	T	N	E	V	F	C	R	S	R	I	S	L	P	K	L	K	L	E	N	V	Q	T	K	D	W	M	Q	L	D	M	L	N	E	L	V	R	C	P	K	S	L	Y	E	R	L	R	E	K	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	S	T	T	T	S				S										T	T	S	S																												S	B						T	T	S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	R	E	S	F	K	V	P	F	D	I	F	E	P	F	K	N	T	L	V	R	H	Q	D	R	F	P	Y	F	V	L	R	Y	F	D	L	N	E	I	F	E	Q	L	R	F	Q	I	D	L	G	T	Y	H	F	S	I	Y	N	K	R	I	G	D	E	D	E	V	R	H	L	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		G	G	G				S	S										B			S														T	T			S	S																				T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	H	H	L	Y	G	F	A	R	I	Q	D	F	A	P	Q	N	Q	P	E	E	W	R	K	L	V	K	T	S	Q	E	P	Y	I	S	K	T	A	P	H	Y	H	L	E	N	E	K	I	G	I	K	F	C	S	A	H	N	N	L	F	P	S	L	Q	T	D	K	T	C	N	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							S		G	G	G	G		G	G	G									B				S	S													B	T	T								S	S					S									T	T	S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	R	S	K	F	N	L	G	T	Q	F	T	A	E	A	F	L	S	V	H	E	L	L	P	M	M	F	Y	Y	L	L	L	T	K	D	Y	S	R	K	E	S	A	D	K	V	E	G	I	I	R	K	E	I	S	N	I	Y	A	I	Y	D	A	F	A	N	N	E	I	N	S	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								G	G	G	S		S					G	G	G												T	T	T	S																													T	T				S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	A	D	L	T	R	R	L	Q	N	T	N	I	L	Q	G	H	L	P	K	Q	M	I	S	I	L	K	G	R	Q	K	D	M	G	K	E	A	E	R	K	I	G	E	M	I	D	D	T	Q	R	R	L	D	L	L	C	K	Q	T	N	Q	K	I	R	I	G	K	R	N	A	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T	S	S			G	G	G	S										T																																S	S				T	T	S	T	T		S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	L	L	K	S	G	K	I	A	D	W	L	V	N	D	M	M	R	F	Q	P	V	Q	K	D	Q	N	N	I	P	I	N	N	S	K	A	N	S	T	E	Y	R	M	L	Q	R	A	L	A	L	F	G	S	E	N	F	R	L	K	A	Y	F	N	Q	M	N	L	V	G	N	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																			S				B		T	T	S		B		G	G	G	S															T					G	G	G								T	T	S	S	S	S	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	N	P	H	P	F	L	A	E	T	Q	W	E	H	Q	T	N	I	L	S	F	Y	R	N	Y	L	E	A	R	K	K	Y	L	K	G	L	K	P	Q	N	W	K	Q	Y	Q	H	F	L	I	L	K	V	Q	K	T	N	R	N	T	L	V	T	G	W	K	N	S	F	N	L	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S			S	S	G	G	G	T	T	G	G	G			S																		T			G	G	G																									T	T	T		B
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	R	G	I	F	T	Q	P	I	R	E	W	F	E	K	H	N	N	S	K	R	I	Y	D	Q	I	L	S	F	D	R	V	G	F	V	A	K	A	I	P	L	Y	F	A	E	E	Y	K	D	N	V	Q	P	F	Y	D	Y	P	F	N	I	G	N	R	L	K	P	K	K	R	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S		T	T														T	T		T	T					T			S	T	T															S					G	G	G	G	S					S		T	T		G	G	G
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	F	L	D	K	K	E	R	V	E	L	W	Q	K	N	K	E	L	F	K	N	Y	P	S	E	K	K	K	T	D	L	A	Y	L	D	F	L	S	W	K	K	F	E	R	E	L	R	L	I	K	N	Q	D	I	V	T	W	L	M	F	K	E	L	F	N	M	A	G	E	I	H
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																				T
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	L	R	D	I	D	T	N	T	A	N	E	E	S	N	N	I	L	N	R	I	M	P	M	K	L	P	V	K	T	Y	E	T	D	N	K	G	N	I	L	K	E	R	P	L	A	T	F	Y	I	E	E	T	E	T	K	V	L	K	Q	G	N	F	K	A	L	V	K	D	R	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G		S								T	T	S	G	G	G																T	T	S																				G	G	G									T		T
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	L	N	G	L	F	S	F	A	E	T	T	D	L	N	L	E	E	H	P	I	S	K	L	S	V	D	L	E	L	I	K	Y	Q	T	T	R	I	S	I	F	E	M	T	L	G	L	E	K	K	L	I	D	K	Y	S	T	L	P	T	D	S	F	R	N	M	L	E	R	W	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					G	G	G				T	T			G	G	G	S																																					T	T	S		S	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050
Sequence	Q	C	K	A	N	R	P	E	L	K	N	Y	V	N	S	L	I	A	V	R	N	A	F	S	H	N	Q	Y	P	M	Y	D	A	T	L	F	A	E	V	K	K	F	T	L	F	P	K	K	I	E	L	N	I	A	P	Q	L	L	E	I	V	G	K	A	I	K	E	I	E	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T			G	G	G																T	T							T	T	T	T	T	T	S					S
	.	.	.
Sequence	S	E	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)