PHUNKEE

Pairing subgrapHs Using NetworK Environment Equivalence


Network context example - AC subgraph






Shared-edge ratio

The similarity of subgraph network context is given by the shared-edge ratio. The shared-edge ratio is simply the weighted proportion of highlighted edges that are shared between the two species.

For example, if we take wi = 1 and we = 0.1 for the subgraph pair above:

The number of internal edges: Ni = 2

    shared Nishared = 2
    unshared Niunshared = 0

The number of external edges: Ne = 10

    shared Neshared = 4
    unshared Neunshared = 6

The weighted total number of edges is given by:

    N = wi*Ni + we*Ne = 3.0

The weighted total number of shared edges is given by:

    Nshared = wi*Nishared + we*Neshared = 2.4

The shared-edge ratio is then given by:

    S = Nshared/N = 0.8




Contact

Structural Bioinformatics Group
Division of Molecular Biosciences
Imperial College, London