Search for human variants

Mutate an entire protein

- Enter variants in the box (using UniProt accessions or chromosomal locations).
- Alternatively, upload a file in VCF format.
- Scores based on March 2013 UniProt release.
- Upload a sequence (raw or FASTA format) or a protein structure file (PDB format), or provide a UniProt accession.
- Why not try using Phyre2 to generate a structural model?

Mutations (human only)

VCF File:

Return structures (Where available, non-commercial users only. Slower than just retrieving scores.)

UniProt Accession
Amino Acid Sequence

Protein Structure Chain ID (default A):

Human protein

Accessibility Statement


Chris Yates

Structural Bioinformatics Group, Imperial College London


If you've found SuSPect useful, please cite our paper:
Yates CM, Filippis I, Kelley LA & Sternberg MJE (2014) SuSPect: Enhanced prediction of single amino acid variant (SAV) phenotype using network features. Journal of Molecular Biology. In press. http://dx.doi.org/10.1016/j.jmb.2014.04.026