PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: d1oisa_

Fold library id	Fold	Superfamily	Family
d1oisa_	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment

Links to external resources
Added to library: Tue Mar 16 13:21:10 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence D T I K W V T L K H N G V I F P P P Y Q P L P S H I K L Y Y D G K P V D L P P Q A E E V A G F F A A L L E S D H A K N P V F Q K N F F N D F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
B
T T
T T
T T T S S G G G

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence L Q V L K E S G G P L N G I E I K E F S R C D F T K M F D Y F Q L Q K E Q K K Q L E K K Q I R L E R E K F E E D Y K F C E L D G R R E Q V G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T
G G G
T T
T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence N F K V E P P D L F R G R G A H P K T G K L K R R V N P E D I V L N L S K D A P V P P A P E G H K W G E I R H D N T V Q W L A M W R E N I F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
T T
T T T T
G G G
S S S
S T T
S
T T
S
T T T

. . . . . . . . . 220

Sequence N S F K Y V R L A A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	D	T	I	K	W	V	T	L	K	H	N	G	V	I	F	P	P	P	Y	Q	P	L	P	S	H	I	K	L	Y	Y	D	G	K	P	V	D	L	P	P	Q	A	E	E	V	A	G	F	F	A	A	L	L	E	S	D	H	A	K	N	P	V	F	Q	K	N	F	F	N	D	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S								B										T	T						T	T																			T	T	T	S	S	G	G	G
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	L	Q	V	L	K	E	S	G	G	P	L	N	G	I	E	I	K	E	F	S	R	C	D	F	T	K	M	F	D	Y	F	Q	L	Q	K	E	Q	K	K	Q	L	E	K	K	Q	I	R	L	E	R	E	K	F	E	E	D	Y	K	F	C	E	L	D	G	R	R	E	Q	V	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T			T	T							G	G	G																		T	T																							T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	N	F	K	V	E	P	P	D	L	F	R	G	R	G	A	H	P	K	T	G	K	L	K	R	R	V	N	P	E	D	I	V	L	N	L	S	K	D	A	P	V	P	P	A	P	E	G	H	K	W	G	E	I	R	H	D	N	T	V	Q	W	L	A	M	W	R	E	N	I	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			B											T	T		T	T	T	T								G	G	G							S	S	S						S	T	T				S						T	T				S						T	T	T
	.	.	.	.	.	.	.	.	.	220
Sequence	N	S	F	K	Y	V	R	L	A	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)