PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: d1a41a_

Fold library id	Fold	Superfamily	Family
d1a41a_	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, catalytic core

Links to external resources
Added to library: Tue Mar 16 13:27:24 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence N A K R D R I F V R V Y N V M K R I N C F I N K N I K K S S T D S N Y Q L A V F M L M E T M F F K E N E T V G L L T L K N K H I E I S P D E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S T T T
T T
T
B G G G T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence I V I K F V G K D K V S H E F V V H K S N R L Y K P L L K L T D D S S P E E F L F N K L S E R K V Y E C I K Q F G I R I K D L R T Y G V N Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
T T S S S
T T
T T S B S S T T
T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence T F L Y N F W T N V K S I S P L P S P K K L I A L T I K Q T A E V V G H T P S I S K R A Y M A T T I L E M V K D K N F L D V V S K T T F D E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S
S S
T T S T T T T

. . . . . . . . . 220 .

Sequence F L S I V V D H V K S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	N	A	K	R	D	R	I	F	V	R	V	Y	N	V	M	K	R	I	N	C	F	I	N	K	N	I	K	K	S	S	T	D	S	N	Y	Q	L	A	V	F	M	L	M	E	T	M	F	F	K	E	N	E	T	V	G	L	L	T	L	K	N	K	H	I	E	I	S	P	D	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																										T	T	S	T	T	T		T	T																								T		B	G	G	G					T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	I	V	I	K	F	V	G	K	D	K	V	S	H	E	F	V	V	H	K	S	N	R	L	Y	K	P	L	L	K	L	T	D	D	S	S	P	E	E	F	L	F	N	K	L	S	E	R	K	V	Y	E	C	I	K	Q	F	G	I	R	I	K	D	L	R	T	Y	G	V	N	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T	T									T	T	S	S	S										T	T		T	T	S	B	S	S	T	T													T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	T	F	L	Y	N	F	W	T	N	V	K	S	I	S	P	L	P	S	P	K	K	L	I	A	L	T	I	K	Q	T	A	E	V	V	G	H	T	P	S	I	S	K	R	A	Y	M	A	T	T	I	L	E	M	V	K	D	K	N	F	L	D	V	V	S	K	T	T	F	D	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													S	S	S																				S	S																		T	T	S	T	T						T	T
	.	.	.	.	.	.	.	.	.	220	.
Sequence	F	L	S	I	V	V	D	H	V	K	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)