PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.0

Fold library entry viewer: c5u71A_

Fold library id	PDB Header	Molecule	Title
c5u71A_	3.87	PDB header: membrane protein, hydrolase	Chain: A: PDB Molecule: cystic fibrosis transmembrane conductance regulator;

Links to external resources
Added to library: Sat Feb 11 00:01:07 2017

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence P L E K A S V V S K L F F S W T R P I L R K G Y R Q R L E L S D I Y Q I P S V D S A D N L S E K L E R E W D R E L A S K K N P K L I N A L R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T
T S
T T T S
T T S
S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence R C F F W R F M F Y G I F L Y L G E V T K A V Q P L L L G R I I A S Y D P D N K E E R S I A I Y L G I G L C L L F I V R T L L L H P A I F G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence L H H I G M Q M R I A M F S L I Y K K T L K L S S R V L D K I S I G Q L V S L L S N N L N K F D E G L A L A H F V W I A P L Q V A L L M G L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T S
G G G T G G G G G T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence I W E L L Q A S A F C G L G F L I V L A L F Q A G L G R M M M K Y R D Q R A G K I S E R L V I T S E M I E N I Q S V K A Y C W E E A M E K M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T T S
T T
S S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence I E N L R Q T E L K L T R K A A Y V R Y F N S S A F F F S G F F V V F L S V L P Y A L I K G I I L R K I F T T I S F C I V L R M A V T R Q F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G G G G T
S T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence P W A V Q T W Y D S L G A I N K I Q D F L Q K Q E Y K T L E Y N L T T T E V V M E N V T A F W E P V L K D I N F K I E R G Q L L A V A G S T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
B
S
S
B
T T
T

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence G A G K T S L L M V I M G E L E P S E G K I K H S G R I S F C S Q F S W I M P G T I K E N I I F G V S Y D E Y R Y R S V I K A C Q L E E D I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S T S S
S
S
S S
S B
T T S
T

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence S K F A E K D N I V L G E G G I T L S G G Q R A R I S L A R A V Y K D A D L Y L L D S P F G Y L D V L T E K E I F E S C V C K L M A N K T R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S
S
B
S S
S S S
S
S S
S S S S
S S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence I L V T S K M E H L K K A D K I L I L H E G S S Y F Y G T F S E L Q N L Q P D F S S K L M T T W N T Y L R Y I T V H K S L I F V L I W C L V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S S S
B
S B
T T S
S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence I F L A E V A A S L V V L W L S T S S Y Y V F Y I Y V G V A D T L L A M G F F R G L P L V H T L I T V S K I L H H K M L H S V L Q A P M S T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T T T
S
T T T S S S S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence L N T L K A G G I L N R F S K D I A I L D D L L P L T I F D F I Q L L L I V I G A I A V V A V L Q P Y I F V A T V P V I V A F I M L R A Y F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T S T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence L Q T S Q Q L K Q L E S E G R S P I F T H L V T S L K G L W T L R A F G R Q P Y F E T L F H K A L N L H T A N W F L Y L S T L R W F Q M R I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence E M I F V I F F I A V T F I S I L T T G E G E G R V G I I L T L A M N I M S T L Q W A V N S S I D V D S L M R S V S R V F K F I D M P T E G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence G Q M T V K D L T A K Y T E G G N A I L E N I S F S I S P G Q R V G L L G R T G S G K S T L L S A F L R L L N T E G E I Q I D G V S W D S I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S T T
S S
S
T T S
T
S B T T B
S S S S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050

Sequence T L Q Q W R K A F G V I P Q K V F I F S G T F R K N L D P Y E Q W S D Q E I W K V A D E V G L R S V I E Q F P G K L D F V L V D G G C V L S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G
S S
S S
S S
S
T
S S S S S S
G G G T S S

. . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080 . . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120

Sequence H G H K Q L M C L A R S V L S K A K I L L L D E P S A H L D P V T Y Q I I R R T L K Q A F A D C T V I L C E H R I E A M L E C Q Q F L V I E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
S
T T T S
S S S G G G S S

. . . . . . . . . 1130 . . . . . . . . .

Sequence E N K V R Q Y D S I Q K L L N E R S L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S

Download: PDB structure FASTA sequence
Hidden Markov model

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Please cite: The Phyre2 web portal for protein modeling, prediction and analysis

Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	P	L	E	K	A	S	V	V	S	K	L	F	F	S	W	T	R	P	I	L	R	K	G	Y	R	Q	R	L	E	L	S	D	I	Y	Q	I	P	S	V	D	S	A	D	N	L	S	E	K	L	E	R	E	W	D	R	E	L	A	S	K	K	N	P	K	L	I	N	A	L	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T		T											S				T	T	T	S					T	T	S																					S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	R	C	F	F	W	R	F	M	F	Y	G	I	F	L	Y	L	G	E	V	T	K	A	V	Q	P	L	L	L	G	R	I	I	A	S	Y	D	P	D	N	K	E	E	R	S	I	A	I	Y	L	G	I	G	L	C	L	L	F	I	V	R	T	L	L	L	H	P	A	I	F	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S																															S	S	T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	L	H	H	I	G	M	Q	M	R	I	A	M	F	S	L	I	Y	K	K	T	L	K	L	S	S	R	V	L	D	K	I	S	I	G	Q	L	V	S	L	L	S	N	N	L	N	K	F	D	E	G	L	A	L	A	H	F	V	W	I	A	P	L	Q	V	A	L	L	M	G	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																						S							T	S																			G	G	G	T	G	G	G	G	G	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	I	W	E	L	L	Q	A	S	A	F	C	G	L	G	F	L	I	V	L	A	L	F	Q	A	G	L	G	R	M	M	M	K	Y	R	D	Q	R	A	G	K	I	S	E	R	L	V	I	T	S	E	M	I	E	N	I	Q	S	V	K	A	Y	C	W	E	E	A	M	E	K	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S			T	T	S																																																T								T		S	S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	I	E	N	L	R	Q	T	E	L	K	L	T	R	K	A	A	Y	V	R	Y	F	N	S	S	A	F	F	F	S	G	F	F	V	V	F	L	S	V	L	P	Y	A	L	I	K	G	I	I	L	R	K	I	F	T	T	I	S	F	C	I	V	L	R	M	A	V	T	R	Q	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																																							G	G	G	G	G	G	T				S																			T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	P	W	A	V	Q	T	W	Y	D	S	L	G	A	I	N	K	I	Q	D	F	L	Q	K	Q	E	Y	K	T	L	E	Y	N	L	T	T	T	E	V	V	M	E	N	V	T	A	F	W	E	P	V	L	K	D	I	N	F	K	I	E	R	G	Q	L	L	A	V	A	G	S	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																						S												S	S			B													S		S					B		T	T									T
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	G	A	G	K	T	S	L	L	M	V	I	M	G	E	L	E	P	S	E	G	K	I	K	H	S	G	R	I	S	F	C	S	Q	F	S	W	I	M	P	G	T	I	K	E	N	I	I	F	G	V	S	Y	D	E	Y	R	Y	R	S	V	I	K	A	C	Q	L	E	E	D	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S	S										T	S	S			S								S							S	S					S	B								T	T	S															T
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	S	K	F	A	E	K	D	N	I	V	L	G	E	G	G	I	T	L	S	G	G	Q	R	A	R	I	S	L	A	R	A	V	Y	K	D	A	D	L	Y	L	L	D	S	P	F	G	Y	L	D	V	L	T	E	K	E	I	F	E	S	C	V	C	K	L	M	A	N	K	T	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S	S		S				B		S	S		S	S	S																S			S						S		S	S	S	S																		S	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	I	L	V	T	S	K	M	E	H	L	K	K	A	D	K	I	L	I	L	H	E	G	S	S	Y	F	Y	G	T	F	S	E	L	Q	N	L	Q	P	D	F	S	S	K	L	M	T	T	W	N	T	Y	L	R	Y	I	T	V	H	K	S	L	I	F	V	L	I	W	C	L	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													S	S						S	S	S		B			S	B																				T								T	S		S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	I	F	L	A	E	V	A	A	S	L	V	V	L	W	L	S	T	S	S	Y	Y	V	F	Y	I	Y	V	G	V	A	D	T	L	L	A	M	G	F	F	R	G	L	P	L	V	H	T	L	I	T	V	S	K	I	L	H	H	K	M	L	H	S	V	L	Q	A	P	M	S	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																		T	T	T	T	T	T											S				T	T	T	S	S																						S	S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	L	N	T	L	K	A	G	G	I	L	N	R	F	S	K	D	I	A	I	L	D	D	L	L	P	L	T	I	F	D	F	I	Q	L	L	L	I	V	I	G	A	I	A	V	V	A	V	L	Q	P	Y	I	F	V	A	T	V	P	V	I	V	A	F	I	M	L	R	A	Y	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S																			T																										S	T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	L	Q	T	S	Q	Q	L	K	Q	L	E	S	E	G	R	S	P	I	F	T	H	L	V	T	S	L	K	G	L	W	T	L	R	A	F	G	R	Q	P	Y	F	E	T	L	F	H	K	A	L	N	L	H	T	A	N	W	F	L	Y	L	S	T	L	R	W	F	Q	M	R	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														T	T													T								T
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	E	M	I	F	V	I	F	F	I	A	V	T	F	I	S	I	L	T	T	G	E	G	E	G	R	V	G	I	I	L	T	L	A	M	N	I	M	S	T	L	Q	W	A	V	N	S	S	I	D	V	D	S	L	M	R	S	V	S	R	V	F	K	F	I	D	M	P	T	E	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																		S				S	S																																											S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	G	Q	M	T	V	K	D	L	T	A	K	Y	T	E	G	G	N	A	I	L	E	N	I	S	F	S	I	S	P	G	Q	R	V	G	L	L	G	R	T	G	S	G	K	S	T	L	L	S	A	F	L	R	L	L	N	T	E	G	E	I	Q	I	D	G	V	S	W	D	S	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												S	S	T	T														S	S							S		T	T	S											T		S								B	T	T	B		S	S	S	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050
Sequence	T	L	Q	Q	W	R	K	A	F	G	V	I	P	Q	K	V	F	I	F	S	G	T	F	R	K	N	L	D	P	Y	E	Q	W	S	D	Q	E	I	W	K	V	A	D	E	V	G	L	R	S	V	I	E	Q	F	P	G	K	L	D	F	V	L	V	D	G	G	C	V	L	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						G	G	G						S	S					S	S								S	S			S													T							S	S	S	S	S	S					G	G	G	T	S	S
	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120
Sequence	H	G	H	K	Q	L	M	C	L	A	R	S	V	L	S	K	A	K	I	L	L	L	D	E	P	S	A	H	L	D	P	V	T	Y	Q	I	I	R	R	T	L	K	Q	A	F	A	D	C	T	V	I	L	C	E	H	R	I	E	A	M	L	E	C	Q	Q	F	L	V	I	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)															T	T		S											S																T	T	T	S							S	S	S	G	G	G	S	S
	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.
Sequence	E	N	K	V	R	Q	Y	D	S	I	Q	K	L	L	N	E	R	S	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T							S