PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.0

Fold library entry viewer: c5ceqA_

Fold library id	PDB Header	Molecule	Title
c5ceqA_	PDB header: transferase/transferase inhibitor	Chain: A: PDB Molecule: mitogen-activated protein kinase kinase kinase 12;	PDBTitle: dlk in complex with inhibitor 2-((1-cyclopentyl-5-(1-(oxetan-3-yl)2 piperidin-4-yl)-1h-pyrazol-3-yl)amino)isonicotinonitrile

Links to external resources
Added to library: Sat Oct 17 10:20:27 2015

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence L W E V P F E E I L D L Q W V G S G A Q G A V F L G R F H G E E V A V K K V R D L K E T D I K H L R K L K H P N I I T F K G V C T Q A P C Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
G G G S T T T T
S S G G G G
G G G T T
T T B
S T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence C I L M E F C A Q G Q L Y E V L R A G R P V T P S L L V D W S M G I A G G M N Y L H L H K I I H R D L K S P N M L I T Y D D V V K I S D F G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
B T T
T T
S
G G G
T T S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence F A G T V A W M A P E V I R N E P V S E K V D I W S F G V V L W E L L T G E I P Y K D V D S S A I I W G V G S N S L H L P V P S S C P D G F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T G G G
T T
T
T T T T
T T
T T S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . .

Sequence K I L L R Q C W N S K P R N R P S F R Q I L L H L D I A S A D V L S T P Q E T Y F K S Q A E W R E E V K L H F E K I K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S S G G G S
T S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Please cite: The Phyre2 web portal for protein modeling, prediction and analysis

Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	L	W	E	V	P	F	E	E	I	L	D	L	Q	W	V	G	S	G	A	Q	G	A	V	F	L	G	R	F	H	G	E	E	V	A	V	K	K	V	R	D	L	K	E	T	D	I	K	H	L	R	K	L	K	H	P	N	I	I	T	F	K	G	V	C	T	Q	A	P	C	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			B			G	G	G	S										T	T									T	T									S	S	G	G	G	G			G	G	G	T	T				T	T	B									S	T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	C	I	L	M	E	F	C	A	Q	G	Q	L	Y	E	V	L	R	A	G	R	P	V	T	P	S	L	L	V	D	W	S	M	G	I	A	G	G	M	N	Y	L	H	L	H	K	I	I	H	R	D	L	K	S	P	N	M	L	I	T	Y	D	D	V	V	K	I	S	D	F	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T		B							T	T																									T	T				S				G	G	G					T	T	S						S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	F	A	G	T	V	A	W	M	A	P	E	V	I	R	N	E	P	V	S	E	K	V	D	I	W	S	F	G	V	V	L	W	E	L	L	T	G	E	I	P	Y	K	D	V	D	S	S	A	I	I	W	G	V	G	S	N	S	L	H	L	P	V	P	S	S	C	P	D	G	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T	G	G	G							T	T					T																				T	T	T	T												T	T								T	T	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.
Sequence	K	I	L	L	R	Q	C	W	N	S	K	P	R	N	R	P	S	F	R	Q	I	L	L	H	L	D	I	A	S	A	D	V	L	S	T	P	Q	E	T	Y	F	K	S	Q	A	E	W	R	E	E	V	K	L	H	F	E	K	I	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T		S	S	G	G	G	S																			T	S