PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.0

Fold library entry viewer: c5a63C_

Fold library id	PDB Header	Molecule	Title
c5a63C_	PDB header: hydrolase	Chain: C: PDB Molecule: gamma-secretase subunit aph-1a;	PDBTitle: cryo-em structure of the human gamma-secretase complex at 3.42 angstrom resolution.

Links to external resources
Added to library: Sat Aug 8 08:21:47 2015

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G A A V F F G C T F V A F G P A F A L F L I T V A G D P L R V I I L V A G A F F W L V S L L L A S V V W F I L V H V T D R S D A R L Q Y G L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence L I F G A A V S V L L Q E V F R F A Y Y K L L K K A D E G L A S L S E D G R S P I S I R Q M A Y V S G L S F G I I S G V F S V I N I L A D A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T S S S
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence L G P G V V G I H G D S P Y Y F L T S A F L T A A I I L L H T F W G V V F F D A C E R R R Y W A L G L V V G S H L L T S G L T F L N P W Y E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S
S
T T S
S T T
T T T S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . .

Sequence A S L L P I Y A V T V S M G L W A F I T A G G S L R S I Q R S L L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
T

Download: PDB structure FASTA sequence
Hidden Markov model

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Please cite: The Phyre2 web portal for protein modeling, prediction and analysis

Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	A	A	V	F	F	G	C	T	F	V	A	F	G	P	A	F	A	L	F	L	I	T	V	A	G	D	P	L	R	V	I	I	L	V	A	G	A	F	F	W	L	V	S	L	L	L	A	S	V	V	W	F	I	L	V	H	V	T	D	R	S	D	A	R	L	Q	Y	G	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																							T	T	T	T																																			S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	L	I	F	G	A	A	V	S	V	L	L	Q	E	V	F	R	F	A	Y	Y	K	L	L	K	K	A	D	E	G	L	A	S	L	S	E	D	G	R	S	P	I	S	I	R	Q	M	A	Y	V	S	G	L	S	F	G	I	I	S	G	V	F	S	V	I	N	I	L	A	D	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																																T	T	T	T	S	S	S		S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	L	G	P	G	V	V	G	I	H	G	D	S	P	Y	Y	F	L	T	S	A	F	L	T	A	A	I	I	L	L	H	T	F	W	G	V	V	F	F	D	A	C	E	R	R	R	Y	W	A	L	G	L	V	V	G	S	H	L	L	T	S	G	L	T	F	L	N	P	W	Y	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S	S			S		T	T	S			S	T																														T																					T	T	T	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.
Sequence	A	S	L	L	P	I	Y	A	V	T	V	S	M	G	L	W	A	F	I	T	A	G	G	S	L	R	S	I	Q	R	S	L	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																					T	S										T