PHYRE Protein Fold Recognition Server

Subscribe to Phyre at Google Groups

Email:

Visit Phyre at Google Groups

Follow @Phyre2server

Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c5a63C_

Fold library id	PDB Header	Molecule	Title
c5a63C_	PDB header: hydrolase	Chain: C: PDB Molecule: gamma-secretase subunit aph-1a;	PDBTitle: cryo-em structure of the human gamma-secretase complex at 3.42 angstrom resolution.

Links to external resources
Added to library: Sat Aug 8 08:21:47 2015

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G A A V F F G C T F V A F G P A F A L F L I T V A G D P L R V I I L V A G A F F W L V S L L L A S V V W F I L V H V T D R S D A R L Q Y G L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence L I F G A A V S V L L Q E V F R F A Y Y K L L K K A D E G L A S L S E D G R S P I S I R Q M A Y V S G L S F G I I S G V F S V I N I L A D A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T S S S
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence L G P G V V G I H G D S P Y Y F L T S A F L T A A I I L L H T F W G V V F F D A C E R R R Y W A L G L V V G S H L L T S G L T F L N P W Y E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S
S
T T S
S T T
T T T S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . .

Sequence A S L L P I Y A V T V S M G L W A F I T A G G S L R S I Q R S L L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement
Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

Disclaimer

Terms and Conditions

Structural Biology Group logo Imperial logo

BBSRC logo
Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	A	A	V	F	F	G	C	T	F	V	A	F	G	P	A	F	A	L	F	L	I	T	V	A	G	D	P	L	R	V	I	I	L	V	A	G	A	F	F	W	L	V	S	L	L	L	A	S	V	V	W	F	I	L	V	H	V	T	D	R	S	D	A	R	L	Q	Y	G	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																							T	T	T	T																																			S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	L	I	F	G	A	A	V	S	V	L	L	Q	E	V	F	R	F	A	Y	Y	K	L	L	K	K	A	D	E	G	L	A	S	L	S	E	D	G	R	S	P	I	S	I	R	Q	M	A	Y	V	S	G	L	S	F	G	I	I	S	G	V	F	S	V	I	N	I	L	A	D	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																																T	T	T	T	S	S	S		S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	L	G	P	G	V	V	G	I	H	G	D	S	P	Y	Y	F	L	T	S	A	F	L	T	A	A	I	I	L	L	H	T	F	W	G	V	V	F	F	D	A	C	E	R	R	R	Y	W	A	L	G	L	V	V	G	S	H	L	L	T	S	G	L	T	F	L	N	P	W	Y	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S	S			S		T	T	S			S	T																														T																					T	T	T	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.
Sequence	A	S	L	L	P	I	Y	A	V	T	V	S	M	G	L	W	A	F	I	T	A	G	G	S	L	R	S	I	Q	R	S	L	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																					T	S										T