PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4yptA_

Fold library id	PDB Header	Molecule	Title
c4yptA_	PDB header: hydrolase	Chain: A: PDB Molecule: replicase polyprotein 1ab;	PDBTitle: x-ray structural of three tandemly linked domains of nsp3 from murine2 hepatitis virus at 2.60 angstroms resolution

Links to external resources
Added to library: Sat Aug 29 08:20:50 2015

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence I Q L D D D A R V F V Q A N M D C L P T D W R L V N K F D S V D G V R T I K Y F E C P G G I F V S S Q G K K F G Y V Q N G S F K E A S V S Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S S
T T
T T T T T T T T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence I R A L L A N K V D V L C T V D G V N F R S C C V A E G E V F G K T L G S V F C D G I N V T K V R C S A I Y K G K V F F Q Y S D L S E A D L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S S S S
T T S B
S T T
T T
B
G G G T T
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence V A V K D A F G F D E P Q L L K Y Y T M L G M C K W P V V V C G N Y F A F K Q S N N N Y I N V A C L M L Q H L S L K F P K W Q W Q E A W N E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
T T
T T
T T
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence F R S G K P L R F V S L V L A K G S F K F N E P S D S I D F M R V V L R E A D L S G A T C N L E F V C K C G V K Q E Q R K G V D A V M H F G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
T T
S
T T
T T T S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence T L D K G D L V R G Y N I A C T C G S K L V H C T Q F N V P F L I C S N T P E G R K L P D D V V A A N I F T G G S V G H Y T H V K C K P K Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T
S
T T
S
T T T T
S S S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . .

Sequence Q L Y D A C N V N K V S E A K G N F T D C L Y L K N L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	I	Q	L	D	D	D	A	R	V	F	V	Q	A	N	M	D	C	L	P	T	D	W	R	L	V	N	K	F	D	S	V	D	G	V	R	T	I	K	Y	F	E	C	P	G	G	I	F	V	S	S	Q	G	K	K	F	G	Y	V	Q	N	G	S	F	K	E	A	S	V	S	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														T	T	S	S			T	T											T	T										T	T	T							T	T							T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	I	R	A	L	L	A	N	K	V	D	V	L	C	T	V	D	G	V	N	F	R	S	C	C	V	A	E	G	E	V	F	G	K	T	L	G	S	V	F	C	D	G	I	N	V	T	K	V	R	C	S	A	I	Y	K	G	K	V	F	F	Q	Y	S	D	L	S	E	A	D	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S									S	S	S	S	S								T	T	S	B							S				T	T				T	T		B			G	G	G	T	T							S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	V	A	V	K	D	A	F	G	F	D	E	P	Q	L	L	K	Y	Y	T	M	L	G	M	C	K	W	P	V	V	V	C	G	N	Y	F	A	F	K	Q	S	N	N	N	Y	I	N	V	A	C	L	M	L	Q	H	L	S	L	K	F	P	K	W	Q	W	Q	E	A	W	N	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T																									T	T								T	T											T	T						S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	F	R	S	G	K	P	L	R	F	V	S	L	V	L	A	K	G	S	F	K	F	N	E	P	S	D	S	I	D	F	M	R	V	V	L	R	E	A	D	L	S	G	A	T	C	N	L	E	F	V	C	K	C	G	V	K	Q	E	Q	R	K	G	V	D	A	V	M	H	F	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T													S				T	T																S			T	T										T	T									T								S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	T	L	D	K	G	D	L	V	R	G	Y	N	I	A	C	T	C	G	S	K	L	V	H	C	T	Q	F	N	V	P	F	L	I	C	S	N	T	P	E	G	R	K	L	P	D	D	V	V	A	A	N	I	F	T	G	G	S	V	G	H	Y	T	H	V	K	C	K	P	K	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S														T	T													S															T	T		S								T	T	T	T								S	S	S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.
Sequence	Q	L	Y	D	A	C	N	V	N	K	V	S	E	A	K	G	N	F	T	D	C	L	Y	L	K	N	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T						S													S