PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4uisB_

Fold library id	PDB Header	Molecule	Title
c4uisB_	PDB header: hydrolase	Chain: B: PDB Molecule: gamma-secretase;	PDBTitle: the cryoem structure of human gamma-secretase complex

Links to external resources
Added to library: Sat Jun 13 08:23:17 2015

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence X X X X X X X X X X X X H V I M L F V P V T L C M V V V V A T I X X X X X X X X X X X X X X X X X X X X X X X X X X X L L L F F F S F I Y L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence G E V F K T Y X X X X X X X X X X L I W N F G X X X X X X X X X X X X X R L Q Q A Y L I M I S A L M X X X X X X X X X X X X X X X X X X X X

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence D X X X X X X X X X X X X X X X X X X X X D X X X X X X X X X X X X X X X X X X W N T T I A C F V A I L I G L C L T L L X X X X X X X X X X

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
T
S S
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 .

Sequence X X X X X X X G L V F Y F A T D Y L V Q P F A D Q L A F H X X

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	X	X	X	X	X	X	X	X	X	X	X	X	H	V	I	M	L	F	V	P	V	T	L	C	M	V	V	V	V	A	T	I	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	L	L	L	F	F	F	S	F	I	Y	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																																	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	G	E	V	F	K	T	Y	X	X	X	X	X	X	X	X	X	X	L	I	W	N	F	G	X	X	X	X	X	X	X	X	X	X	X	X	X	R	L	Q	Q	A	Y	L	I	M	I	S	A	L	M	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																																			S																									T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	D	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	D	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	W	N	T	T	I	A	C	F	V	A	I	L	I	G	L	C	L	T	L	L	X	X	X	X	X	X	X	X	X	X
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)															T				T																			S	S		S																							S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.
Sequence	X	X	X	X	X	X	X	G	L	V	F	Y	F	A	T	D	Y	L	V	Q	P	F	A	D	Q	L	A	F	H	X	X
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																		T											S