PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4i74A_

Fold library id	PDB Header	Molecule	Title
c4i74A_	PDB header: hydrolase/hydrolase inhibitor	Chain: A: PDB Molecule: inosine-adenosine-guanosine-nucleoside hydrolase;	PDBTitle: crystal structure of the trypanosoma brucei inosine-adenosine-2 guanosine nucleoside hydrolase in complex with compound uamc-003123 and allosterically inhibited by a ni2+ ion

Links to external resources
Added to library: Sat Aug 10 08:33:29 2013

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G S H M A K T V I L D H D G N K D D F V A M I L L L S N P K K V N L I G C I C T D A D C F V E N G F D V T G K I M C A M H R L I K T P L F P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T
T T T
S S S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence I G K S T A T A V N A F P T E W R F S A K N L D D M P F L N I V E D V A L W E K L K P E N E A H N G Q Q L L A D L V M K S K E K V T V C V T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T S G G G
T
B
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence G P L S N M A W C I E K Y G E A F T S K V E E C V I M G G A V D V G G N V F L P T T D G S A E W N I Y W D P P A A K K V L C C P N I R C V L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S T T T
S S S
S
T T
S
S
T
T T S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence F S L D A T N T V P V R S V D V K G F G A Q N Q Y L L S Q M V G T M W A M S T H E E I L R D G D A Y Y A W D A L T A A Y I L E P T I A T L E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
G G G G G G T T S T
G G G B
T T S S
G G G S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . .

Sequence P V A L D V D V S K G K S E G R T P R A S G P C V H V A R N P S K Q M F H D L V F A S T R V C

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
S S S T T T T
B
S
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	S	H	M	A	K	T	V	I	L	D	H	D	G	N	K	D	D	F	V	A	M	I	L	L	L	S	N	P	K	K	V	N	L	I	G	C	I	C	T	D	A	D	C	F	V	E	N	G	F	D	V	T	G	K	I	M	C	A	M	H	R	L	I	K	T	P	L	F	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S																							T		T	T	T										S	S	S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	I	G	K	S	T	A	T	A	V	N	A	F	P	T	E	W	R	F	S	A	K	N	L	D	D	M	P	F	L	N	I	V	E	D	V	A	L	W	E	K	L	K	P	E	N	E	A	H	N	G	Q	Q	L	L	A	D	L	V	M	K	S	K	E	K	V	T	V	C	V	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	S								T							T	S	G	G	G																		T		B													S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	G	P	L	S	N	M	A	W	C	I	E	K	Y	G	E	A	F	T	S	K	V	E	E	C	V	I	M	G	G	A	V	D	V	G	G	N	V	F	L	P	T	T	D	G	S	A	E	W	N	I	Y	W	D	P	P	A	A	K	K	V	L	C	C	P	N	I	R	C	V	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S		S											T					T	T											S	S	S			S				T	T			S		S																T		T	T	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	F	S	L	D	A	T	N	T	V	P	V	R	S	V	D	V	K	G	F	G	A	Q	N	Q	Y	L	L	S	Q	M	V	G	T	M	W	A	M	S	T	H	E	E	I	L	R	D	G	D	A	Y	Y	A	W	D	A	L	T	A	A	Y	I	L	E	P	T	I	A	T	L	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T									G	G	G	G	G	G	T	T	S												T			G	G	G	B		T	T	S	S																G	G	G	S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.
Sequence	P	V	A	L	D	V	D	V	S	K	G	K	S	E	G	R	T	P	R	A	S	G	P	C	V	H	V	A	R	N	P	S	K	Q	M	F	H	D	L	V	F	A	S	T	R	V	C
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				B					S	S	S	T	T	T	T				B											S														T	T