PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.0

Fold library entry viewer: c4hymA_

Fold library id	PDB Header	Molecule	Title
c4hymA_	PDB header: isomerase/isomerase inhibitor	Chain: A: PDB Molecule: topoisomerase iv, subunit b;	PDBTitle: pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv,2 part i: structure guided discovery and optimization of dual targeting3 agents with potent, broad-spectrum enzymatic activity.

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Added to library: Sat Feb 16 08:36:28 2013

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence K S I E V L T G L D P V K K R P G M Y T N I E N P N H L I Q E I I D N S V D E V L A G F A S K I N I T L Y E D N S I E V A D D G R G M P V D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
G G G T S
T T S S T T S
T T S
S S
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence I H P E H K M S G I E L I M T K L H S G G K F S N G G L H G V G V S V V N A L S T R L E A E I K R D G N V Y H I V F E D G F K T K D L E I I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T S S S
S S S S
T T T T T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence D N V G K K N T G T K I R F W P N K K Y F D D I K V N F K A L K N L L E A K A I L C K A L T I K Y S N E I K K E K L T W H F E T G L K G Y L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
G G G
S
S
T
T T
T T T T
T T T T T T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence D H K L E A E T L P A E P F I I D N F S N G D S Y L D A V F C W C E D P S E S I K N S Y V N L I P T P Q D G T H V T G L K N G I Y D A I K A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
S S S
S
S S
T T
T T
B

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence Y I E K N S N I K I T A N D S F A Q L N Y V I S V K I T N P Q F A G Q T K E K L S N K D V T N F V A T A V K D L L T I W L N Q N P D E A R Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S
T T T T
T

. . . . . . . . . 360 .

Sequence I V E N I S K V A Q K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T

Download: PDB structure FASTA sequence
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Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	K	S	I	E	V	L	T	G	L	D	P	V	K	K	R	P	G	M	Y	T	N	I	E	N	P	N	H	L	I	Q	E	I	I	D	N	S	V	D	E	V	L	A	G	F	A	S	K	I	N	I	T	L	Y	E	D	N	S	I	E	V	A	D	D	G	R	G	M	P	V	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S							G	G	G	T	S		T	T	S	S																	T	T	S										T	T	S								S	S					S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	I	H	P	E	H	K	M	S	G	I	E	L	I	M	T	K	L	H	S	G	G	K	F	S	N	G	G	L	H	G	V	G	V	S	V	V	N	A	L	S	T	R	L	E	A	E	I	K	R	D	G	N	V	Y	H	I	V	F	E	D	G	F	K	T	K	D	L	E	I	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T	T	T										S						S	S					S	S	S	S		T						T											T	T									T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	D	N	V	G	K	K	N	T	G	T	K	I	R	F	W	P	N	K	K	Y	F	D	D	I	K	V	N	F	K	A	L	K	N	L	L	E	A	K	A	I	L	C	K	A	L	T	I	K	Y	S	N	E	I	K	K	E	K	L	T	W	H	F	E	T	G	L	K	G	Y	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T												G	G	G		S			S																T		T	T								T	T	T	T								T	T	T	T	T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	D	H	K	L	E	A	E	T	L	P	A	E	P	F	I	I	D	N	F	S	N	G	D	S	Y	L	D	A	V	F	C	W	C	E	D	P	S	E	S	I	K	N	S	Y	V	N	L	I	P	T	P	Q	D	G	T	H	V	T	G	L	K	N	G	I	Y	D	A	I	K	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						S															S	S	S											S			S	S								T	T				T	T		B
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	Y	I	E	K	N	S	N	I	K	I	T	A	N	D	S	F	A	Q	L	N	Y	V	I	S	V	K	I	T	N	P	Q	F	A	G	Q	T	K	E	K	L	S	N	K	D	V	T	N	F	V	A	T	A	V	K	D	L	L	T	I	W	L	N	Q	N	P	D	E	A	R	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																	T	T										S	S					T	T	T	T						T
	.	.	.	.	.	.	.	.	.	360	.
Sequence	I	V	E	N	I	S	K	V	A	Q	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										T