PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4htfA_

Fold library id	PDB Header	Molecule	Title
c4htfA_	PDB header: transferase	Chain: A: PDB Molecule: s-adenosylmethionine-dependent methyltransferase;	PDBTitle: crystal structure of s-adenosylmethionine-dependent methyltransferase2 from escherichia coli in complex with s-adenosylmethionine.

Links to external resources
Added to library: Thu Jan 10 02:33:13 2013

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence D I A E K F S R N I Y G T T K G Q L R Q A I L W Q D L D R V L A E X G P Q K L R V L D A G G G E G Q T A I K X A E R G H Q V I L C D L S A Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T S
T
S S
T
T T
T T
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence X I D R A K Q A A E A G V S D N X Q F I H C A A Q D V A S H L E T P V D L I L F H A V L E W V A D P R S V L Q T L W S V L R P G G V L S L X

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G S
G G G T G G G
S S
S
G G G
S
T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence F Y N A H G L L X H N X V A G N F D Y V Q A G X P K K L S P D Y P R D P T Q V Y L W L E E A G W Q I X G K T G V R V F H D Y L R E K H Q Q R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) B T T
T T
S
B
T T
S S S G G G
S S G G G G T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . .

Sequence D Y E A L L E L E T R Y C R Q E P Y I T L G R Y I H V T A R K P Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S T T G G G G
S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	D	I	A	E	K	F	S	R	N	I	Y	G	T	T	K	G	Q	L	R	Q	A	I	L	W	Q	D	L	D	R	V	L	A	E	X	G	P	Q	K	L	R	V	L	D	A	G	G	G	E	G	Q	T	A	I	K	X	A	E	R	G	H	Q	V	I	L	C	D	L	S	A	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								S		T	T	S																						T		S	S								T		T	T										T	T								S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	X	I	D	R	A	K	Q	A	A	E	A	G	V	S	D	N	X	Q	F	I	H	C	A	A	Q	D	V	A	S	H	L	E	T	P	V	D	L	I	L	F	H	A	V	L	E	W	V	A	D	P	R	S	V	L	Q	T	L	W	S	V	L	R	P	G	G	V	L	S	L	X
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														G	G	G						S		G	G	G	T	G	G	G		S	S									S		G	G	G		S												T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	F	Y	N	A	H	G	L	L	X	H	N	X	V	A	G	N	F	D	Y	V	Q	A	G	X	P	K	K	L	S	P	D	Y	P	R	D	P	T	Q	V	Y	L	W	L	E	E	A	G	W	Q	I	X	G	K	T	G	V	R	V	F	H	D	Y	L	R	E	K	H	Q	Q	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			B											T	T							T	T								S			B												T	T										S	S	S	G	G	G		S	S	G	G	G	G	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.
Sequence	D	Y	E	A	L	L	E	L	E	T	R	Y	C	R	Q	E	P	Y	I	T	L	G	R	Y	I	H	V	T	A	R	K	P	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T	S	T	T	G	G	G	G		S