PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4geeA_

Fold library id	PDB Header	Molecule	Title
c4geeA_	PDB header: isomerase/isomerase inhibitor	Chain: A: PDB Molecule: dna gyrase subunit b;	PDBTitle: pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv,2 part i: structure guided discovery and optimization of dual targeting3 agents with potent, broad-spectrum enzymatic activity.

Links to external resources
Added to library: Sat Feb 16 08:38:37 2013

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G L E A V R K R P G M Y I G S T S G E G L H H L V W E I V D N S I D E A L A G F A K S I Q V I I E P D D S I T V I D D G R G I P V G I Q A K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T
S
S S T T
T T S
S S
S B
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence T G R P A V E T V F T V L H G V G S S V V N A L S T S L D V R V Y K D G K V Y Y Q E Y R R G A V V D D L K V I E E T D R H G T T V H F I P D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S B S
T T T T T
S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . .

Sequence P E I F T E T T V Y D F D K L A T R V R E L A F L N R G L H I S I E D R R E G Q E D K K E Y H Y E G L E H

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
S
T T T
S T T
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	L	E	A	V	R	K	R	P	G	M	Y	I	G	S	T	S	G	E	G	L	H	H	L	V	W	E	I	V	D	N	S	I	D	E	A	L	A	G	F	A	K	S	I	Q	V	I	I	E	P	D	D	S	I	T	V	I	D	D	G	R	G	I	P	V	G	I	Q	A	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T												S		S	S																					T	T											T	T	S								S	S					S	B		T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	T	G	R	P	A	V	E	T	V	F	T	V	L	H	G	V	G	S	S	V	V	N	A	L	S	T	S	L	D	V	R	V	Y	K	D	G	K	V	Y	Y	Q	E	Y	R	R	G	A	V	V	D	D	L	K	V	I	E	E	T	D	R	H	G	T	T	V	H	F	I	P	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S	S	B								S												T											T	T									T	T				S									S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.
Sequence	P	E	I	F	T	E	T	T	V	Y	D	F	D	K	L	A	T	R	V	R	E	L	A	F	L	N	R	G	L	H	I	S	I	E	D	R	R	E	G	Q	E	D	K	K	E	Y	H	Y	E	G	L	E	H
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	T			S																				T	T	T									S	T	T												T	T