PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4f1hA_

Fold library id	PDB Header	Molecule	Title
c4f1hA_	PDB header: hydrolase/dna	Chain: A: PDB Molecule: tyrosyl-dna phosphodiesterase 2;	PDBTitle: crystal structure of tdp2 from danio rerio complexed with a single2 strand dna

Links to external resources
Added to library: Sat Nov 3 17:34:41 2012

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence D S K L S I I S W N V D G L D T L N L A D R A R G L C S Y L A L Y T P D V V F L Q E L I P A Y V Q Y L K K R A V S Y L F F E G S D D G Y F T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T
S
T T S
S S S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence G I M L R K S R V K F L E S E I I C F P T T Q M M R N L L I A Q V T F S G Q K L Y L M T S H L E S C K N Q S Q E R T K Q L R V V L Q K I K E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
T T
S S
T T
B
S G G G

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence A P E D A I V I F A G D T N L R D A E V A N V G G L P A G V C D V W E Q L G K Q E H C R Y T W D T K A N S N K T V P Y V S R C R F D R I F L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T T
T T T S S
T T T T
G G G
S T T T
S S
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250

Sequence R S A K T A P P V T P D H M A L I G M E K L D C G R Y T S D H W G I Y C T F N T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
S
T T S S
S
S B

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	D	S	K	L	S	I	I	S	W	N	V	D	G	L	D	T	L	N	L	A	D	R	A	R	G	L	C	S	Y	L	A	L	Y	T	P	D	V	V	F	L	Q	E	L	I	P	A	Y	V	Q	Y	L	K	K	R	A	V	S	Y	L	F	F	E	G	S	D	D	G	Y	F	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T			T	T																		S																				T	T						S		S	S	S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	G	I	M	L	R	K	S	R	V	K	F	L	E	S	E	I	I	C	F	P	T	T	Q	M	M	R	N	L	L	I	A	Q	V	T	F	S	G	Q	K	L	Y	L	M	T	S	H	L	E	S	C	K	N	Q	S	Q	E	R	T	K	Q	L	R	V	V	L	Q	K	I	K	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	T												T	T		S	S												T	T									B				S	G	G	G
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	A	P	E	D	A	I	V	I	F	A	G	D	T	N	L	R	D	A	E	V	A	N	V	G	G	L	P	A	G	V	C	D	V	W	E	Q	L	G	K	Q	E	H	C	R	Y	T	W	D	T	K	A	N	S	N	K	T	V	P	Y	V	S	R	C	R	F	D	R	I	F	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S		T	T																		T	T	T	S	S		T	T								T	T			G	G	G			S			T	T	T			S	S			S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250
Sequence	R	S	A	K	T	A	P	P	V	T	P	D	H	M	A	L	I	G	M	E	K	L	D	C	G	R	Y	T	S	D	H	W	G	I	Y	C	T	F	N	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	S														S			T	T	S	S		S		S	B