PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4aq5A_

Fold library id	PDB Header	Molecule	Title
c4aq5A_	PDB header: membrane protein	Chain: A: PDB Molecule: acetylcholine receptor subunit alpha;	PDBTitle: gating movement in acetylcholine receptor analysed by time-2 resolved electron cryo-microscopy (closed class)

Links to external resources
Added to library: Sat Aug 4 14:05:37 2012

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence S E H E T R L V A N L L E N Y N K V I R P V E H H T H F V D I T V G L Q L I Q L I N V D E V N Q I V E T N V R L R Q Q W I D V R L R W N P A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
S S
S S S S
T T T T
T T
B
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence D Y G G I K K I R L P S D D V W L P D L V L Y N N A D G D F A I V H M T K L L L D Y T G K I M W T P P A I F K S Y C E I I V T H F P F D Q Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S S G G G S
S S
S
T T
S S
S B
G G G S S S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence N C T M K L G I W T Y D G T K V S I S P E S D R P D L S T F M E S G E W V M K D Y R G W K H W V Y Y T C C P D T P Y L D I T Y H F I M Q R I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S
T T T
S G G G
T T
S S
S S S S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence P L Y F V V N V I I P C L L F S F L T V L V F Y L P T D S G E K M T L S I S V L L S L T V F L L V I V E L I P S T S S A V P L I G K Y M L F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T
G G G T T S
G G G

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence T M I F V I S S I I V T V V V I N T H H R S P S T H S A I E G V K Y I A E H M K S D E E S S N A A E E W K Y V A M V I D H I L L C V F M L I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T
T T S
S S S

. . . . . . . . . 360 . . . . . . . . . 370

Sequence C I I G T V S V F A G R L I E L S Q E G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	S	E	H	E	T	R	L	V	A	N	L	L	E	N	Y	N	K	V	I	R	P	V	E	H	H	T	H	F	V	D	I	T	V	G	L	Q	L	I	Q	L	I	N	V	D	E	V	N	Q	I	V	E	T	N	V	R	L	R	Q	Q	W	I	D	V	R	L	R	W	N	P	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T											T			S	S						S	S	S	S																		T	T	T	T															T	T		B			T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	D	Y	G	G	I	K	K	I	R	L	P	S	D	D	V	W	L	P	D	L	V	L	Y	N	N	A	D	G	D	F	A	I	V	H	M	T	K	L	L	L	D	Y	T	G	K	I	M	W	T	P	P	A	I	F	K	S	Y	C	E	I	I	V	T	H	F	P	F	D	Q	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T					S	S					G	G	G	S								S	S				S			T	T		S	S							S	B																			G	G	G	S	S	S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	N	C	T	M	K	L	G	I	W	T	Y	D	G	T	K	V	S	I	S	P	E	S	D	R	P	D	L	S	T	F	M	E	S	G	E	W	V	M	K	D	Y	R	G	W	K	H	W	V	Y	Y	T	C	C	P	D	T	P	Y	L	D	I	T	Y	H	F	I	M	Q	R	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	S			T	T	T											S	G	G	G			T	T		S	S															S	S	S	S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	P	L	Y	F	V	V	N	V	I	I	P	C	L	L	F	S	F	L	T	V	L	V	F	Y	L	P	T	D	S	G	E	K	M	T	L	S	I	S	V	L	L	S	L	T	V	F	L	L	V	I	V	E	L	I	P	S	T	S	S	A	V	P	L	I	G	K	Y	M	L	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T																												G	G	G	T	T																											S				G	G	G
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	T	M	I	F	V	I	S	S	I	I	V	T	V	V	V	I	N	T	H	H	R	S	P	S	T	H	S	A	I	E	G	V	K	Y	I	A	E	H	M	K	S	D	E	E	S	S	N	A	A	E	E	W	K	Y	V	A	M	V	I	D	H	I	L	L	C	V	F	M	L	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																							T	T	T																											T	T	S		S	S	S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370
Sequence	C	I	I	G	T	V	S	V	F	A	G	R	L	I	E	L	S	Q	E	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)