PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4a6dA_

Fold library id	PDB Header	Molecule	Title
c4a6dA_	PDB header: transferase	Chain: A: PDB Molecule: hydroxyindole o-methyltransferase;	PDBTitle: crystal structure of human n-acetylserotonin2 methyltransferase (asmt) in complex with sam

Links to external resources
Added to library: Sat Nov 10 13:41:59 2012

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence M G S S E D Q A Y R L L N D Y A N G F M V S Q V L F A A C E L G V F D L L A E A P G P L D V A A V A A G V R A S A H G T E L L L D I C V S L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
T S S S
B
T
T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence K L L K V E T R G G K A F Y R N T E L S S D Y L T T V S P T S Q C S M L K Y M G R T S Y R C W G H L A D A V R E G R N Q Y L E T F G V P A E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S T T
S T T S T T
T T T T S
S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence E L F T A I Y R S E G E R L Q F M Q A L Q E V W S V N G R S V L T A F D L S V F P L M C D L G G G A G A L A K E C M S L Y P G C K I T V F D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T S S T T S S
G G G
S T
T T S
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence I P E V V W T A K Q H F S F E E Q I D F Q E G D F F K D P L P E A D L Y I L A R V L H D W A D G K C S H L L E R I Y H T C K P G G G I L V I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
S S
T T T S
S S S G G G S
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . .

Sequence E S L L D E D R R G P L L T Q L Y S L N M L V Q T E G Q E R T P T H Y H M L L S S A G F R D F Q F K K T G A I Y D A I L A R K G T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
S S S
T
S S S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	M	G	S	S	E	D	Q	A	Y	R	L	L	N	D	Y	A	N	G	F	M	V	S	Q	V	L	F	A	A	C	E	L	G	V	F	D	L	L	A	E	A	P	G	P	L	D	V	A	A	V	A	A	G	V	R	A	S	A	H	G	T	E	L	L	L	D	I	C	V	S	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T	S																											T								S	S	S		B										T																T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	K	L	L	K	V	E	T	R	G	G	K	A	F	Y	R	N	T	E	L	S	S	D	Y	L	T	T	V	S	P	T	S	Q	C	S	M	L	K	Y	M	G	R	T	S	Y	R	C	W	G	H	L	A	D	A	V	R	E	G	R	N	Q	Y	L	E	T	F	G	V	P	A	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S							T	T															S	T	T	S	T	T												T						T	T								T	S								S				S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	E	L	F	T	A	I	Y	R	S	E	G	E	R	L	Q	F	M	Q	A	L	Q	E	V	W	S	V	N	G	R	S	V	L	T	A	F	D	L	S	V	F	P	L	M	C	D	L	G	G	G	A	G	A	L	A	K	E	C	M	S	L	Y	P	G	C	K	I	T	V	F	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S						T	S	S													T	T											S	S		G	G	G		S						T		T	T	S											S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	I	P	E	V	V	W	T	A	K	Q	H	F	S	F	E	E	Q	I	D	F	Q	E	G	D	F	F	K	D	P	L	P	E	A	D	L	Y	I	L	A	R	V	L	H	D	W	A	D	G	K	C	S	H	L	L	E	R	I	Y	H	T	C	K	P	G	G	G	I	L	V	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												S					S						S		T	T	T	S						S						S	S	G	G	G	S																		T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.
Sequence	E	S	L	L	D	E	D	R	R	G	P	L	L	T	Q	L	Y	S	L	N	M	L	V	Q	T	E	G	Q	E	R	T	P	T	H	Y	H	M	L	L	S	S	A	G	F	R	D	F	Q	F	K	K	T	G	A	I	Y	D	A	I	L	A	R	K	G	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	S																S	S	S																	T										S	S	S