PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3s5mA_

Fold library id	PDB Header	Molecule	Title
c3s5mA_	PDB header: hydrolase	Chain: A: PDB Molecule: falcilysin;	PDBTitle: crystal structures of falcilysin, a m16 metalloprotease from the2 malaria parasite plasmodium falciparum

Links to external resources
Added to library: Sat May 26 12:52:07 2012

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence T P E W I H E K S P K H N S Y D I I E K R Y N E E F K M T Y T V Y Q H K K A K T Q V I S L G T N D P L D V E Q A F A F Y V K T L T H S G K G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G G G G S
T T T T T T T T T
T T
S S S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence I P H I L E H S V L S G S K N Y N Y K N S I G L L E K G T L H T H L N A Y T F N D R T V Y M A G S M N N K D F F N I M G V Y M D S V F Q P N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
B T T B
T T S
S S S S S B G

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence V L E N K Y I F E T E G W T Y E V E K L K E D E K G K A E I P Q M K D Y K V S F N G I V Y N E M K G A L S S P L E D L Y H E E M K Y M F P D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G T
T
T T T T T
T T S
T T
T T
T T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence N V H S N N S G G D P K E I T N L T Y E E F K E F Y Y K N Y N P K K V K V F F F S K N N P T E L L N F V D Q Y L G Q L D Y S K Y R D D A V E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S G G G S
T T
T T
S
T T T
S S
T T T
G G G

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence S V E Y Q T Y K K G P F Y I K K K Y G D H S E E K E N L V S V A W L L N P K V D G S H S S D L S L E N P T D Y F V L L I I N N L L I H T P E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
S S
S S
B
S T T
S S S T T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence S V L Y K A L T D C G L G N N V I D R G L N D S L V Q Y I F S I G L K G I K R N N E K I K N F D K V H Y E V E D V I M N A L K K V V K E G F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S
S
S S S S
T T
T T
S
G G G

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence N K S A V E A S I N N I E F I L K E A N L K T S K S I D F V F E M T S K L N Y N R D P L L I F E F E K Y L N I V K N K I K N E P M Y L E K F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S T T T T
T T T T T S S T T

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence V E K H F I N N A H R S V I L L E G D E N Y A Q E Q E N L E K Q E L K K R I E N F N E Q E K E Q V I K N F E E L S K Y K N A E E S P E H L N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
S S
T

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence K F P I I S I S D L N K K T L E V P V N V Y F T N I N E N N N I M E T Y N K L K T N E H M L K D N M D V F L K K Y V L K E T K Y E G N V P I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
G G G S
S S
T T T
S
T
T T
T T T T

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence L V Y E M P T T G I V Y L Q F V F S L D H L T V D E L A Y L N L F K T L I L E N K T N K R S S E D F V I L R E K N I G S M S A N V A L Y S K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T
T T T T T
B S S S
S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence D D H L N V T D K Y N A Q A L F N L E M H V L S H K C N D A L N I A L E A V K E S D F S N K K K V I D I L K R K I N G M K T T F S E K G Y A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B T T B
T T
G G G S B
T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence I L M K Y V K A H L N S K H Y A H N I I Y G Y E N Y L K L Q E Q L E L A E N D F K T L E N I L V R I R N K I F N K K N L M V S V T S D Y G A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T T
S
S
S T T
G G G

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence L K H L F V N S N E S L K N L V S Y F E E N D K Y I N D M Q N K V N D P T V M G W N E E I K S K K L F D E E K V K K E F F V L P T F V N S V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T G G G G S
S S S
T T
T T
S S B

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence S M S G I L F K P G E Y L D P S F T V I V A A L K N S Y L W D T V R G L N G A Y G V F A D I E Y D G S V V F L S A R D P N L E K T L A T F R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T
B
T T T T T T
S
T T S S B S
S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050

Sequence E S A K G L R K M A D T M T E N D L L R Y I I N T I G T I D K P R R G I E L S K L S F L R L I S N E S E Q D R V E F R K R I M N T K K E D F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S
T T T
T

. . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080 . . . . . . . . . 1090 . . . .

Sequence Y K F A D L L E S K V N E F E K N I V I I T T K E K A N E Y I A N V D G E F K K V L I E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
T
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	T	P	E	W	I	H	E	K	S	P	K	H	N	S	Y	D	I	I	E	K	R	Y	N	E	E	F	K	M	T	Y	T	V	Y	Q	H	K	K	A	K	T	Q	V	I	S	L	G	T	N	D	P	L	D	V	E	Q	A	F	A	F	Y	V	K	T	L	T	H	S	G	K	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			G	G	G	G	G	G	S				T	T										T	T	T	T									T	T	T												T	T															S	S	S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	I	P	H	I	L	E	H	S	V	L	S	G	S	K	N	Y	N	Y	K	N	S	I	G	L	L	E	K	G	T	L	H	T	H	L	N	A	Y	T	F	N	D	R	T	V	Y	M	A	G	S	M	N	N	K	D	F	F	N	I	M	G	V	Y	M	D	S	V	F	Q	P	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									T	T	S		B	T	T	B			T	T								S												S	S									S	S																	S	B	G
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	V	L	E	N	K	Y	I	F	E	T	E	G	W	T	Y	E	V	E	K	L	K	E	D	E	K	G	K	A	E	I	P	Q	M	K	D	Y	K	V	S	F	N	G	I	V	Y	N	E	M	K	G	A	L	S	S	P	L	E	D	L	Y	H	E	E	M	K	Y	M	F	P	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	T									T										T	T	T	T	T		T	T	S				T	T																	T	T																T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	N	V	H	S	N	N	S	G	G	D	P	K	E	I	T	N	L	T	Y	E	E	F	K	E	F	Y	Y	K	N	Y	N	P	K	K	V	K	V	F	F	F	S	K	N	N	P	T	E	L	L	N	F	V	D	Q	Y	L	G	Q	L	D	Y	S	K	Y	R	D	D	A	V	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	G	G	G	S		T	T							T	T														S		T	T	T								S	S		T												T	T			G	G	G
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	S	V	E	Y	Q	T	Y	K	K	G	P	F	Y	I	K	K	K	Y	G	D	H	S	E	E	K	E	N	L	V	S	V	A	W	L	L	N	P	K	V	D	G	S	H	S	S	D	L	S	L	E	N	P	T	D	Y	F	V	L	L	I	I	N	N	L	L	I	H	T	P	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						B																	S	S											S	S		B							S	T	T				S																S	S	T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	S	V	L	Y	K	A	L	T	D	C	G	L	G	N	N	V	I	D	R	G	L	N	D	S	L	V	Q	Y	I	F	S	I	G	L	K	G	I	K	R	N	N	E	K	I	K	N	F	D	K	V	H	Y	E	V	E	D	V	I	M	N	A	L	K	K	V	V	K	E	G	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S											S		S										S	S	S	S												T	T		T	T		S		G	G	G
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	N	K	S	A	V	E	A	S	I	N	N	I	E	F	I	L	K	E	A	N	L	K	T	S	K	S	I	D	F	V	F	E	M	T	S	K	L	N	Y	N	R	D	P	L	L	I	F	E	F	E	K	Y	L	N	I	V	K	N	K	I	K	N	E	P	M	Y	L	E	K	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																				T	T	S	T	T															T	T			T	T	T	T	T	S															S	T	T
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	V	E	K	H	F	I	N	N	A	H	R	S	V	I	L	L	E	G	D	E	N	Y	A	Q	E	Q	E	N	L	E	K	Q	E	L	K	K	R	I	E	N	F	N	E	Q	E	K	E	Q	V	I	K	N	F	E	E	L	S	K	Y	K	N	A	E	E	S	P	E	H	L	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T	T													S	S																																																	T
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	K	F	P	I	I	S	I	S	D	L	N	K	K	T	L	E	V	P	V	N	V	Y	F	T	N	I	N	E	N	N	N	I	M	E	T	Y	N	K	L	K	T	N	E	H	M	L	K	D	N	M	D	V	F	L	K	K	Y	V	L	K	E	T	K	Y	E	G	N	V	P	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S					G	G	G	S		S	S													T	T	T		S											T																	T	T				T	T	T	T
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	L	V	Y	E	M	P	T	T	G	I	V	Y	L	Q	F	V	F	S	L	D	H	L	T	V	D	E	L	A	Y	L	N	L	F	K	T	L	I	L	E	N	K	T	N	K	R	S	S	E	D	F	V	I	L	R	E	K	N	I	G	S	M	S	A	N	V	A	L	Y	S	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T											T	T							T	T								T	T	T			B	S	S	S														S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	D	D	H	L	N	V	T	D	K	Y	N	A	Q	A	L	F	N	L	E	M	H	V	L	S	H	K	C	N	D	A	L	N	I	A	L	E	A	V	K	E	S	D	F	S	N	K	K	K	V	I	D	I	L	K	R	K	I	N	G	M	K	T	T	F	S	E	K	G	Y	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		B	T	T	B				T	T														G	G	G														S	B		T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	I	L	M	K	Y	V	K	A	H	L	N	S	K	H	Y	A	H	N	I	I	Y	G	Y	E	N	Y	L	K	L	Q	E	Q	L	E	L	A	E	N	D	F	K	T	L	E	N	I	L	V	R	I	R	N	K	I	F	N	K	K	N	L	M	V	S	V	T	S	D	Y	G	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	T	T	T												S																																	S		S	T	T									G	G	G
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	L	K	H	L	F	V	N	S	N	E	S	L	K	N	L	V	S	Y	F	E	E	N	D	K	Y	I	N	D	M	Q	N	K	V	N	D	P	T	V	M	G	W	N	E	E	I	K	S	K	K	L	F	D	E	E	K	V	K	K	E	F	F	V	L	P	T	F	V	N	S	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T					T	T	T														G	G	G	G	S					S	S	S															T	T				T	T												S	S	B
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	S	M	S	G	I	L	F	K	P	G	E	Y	L	D	P	S	F	T	V	I	V	A	A	L	K	N	S	Y	L	W	D	T	V	R	G	L	N	G	A	Y	G	V	F	A	D	I	E	Y	D	G	S	V	V	F	L	S	A	R	D	P	N	L	E	K	T	L	A	T	F	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							S		T	T		B			T												T							T	T	T	T			S								T	T	S								S	B	S		S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050
Sequence	E	S	A	K	G	L	R	K	M	A	D	T	M	T	E	N	D	L	L	R	Y	I	I	N	T	I	G	T	I	D	K	P	R	R	G	I	E	L	S	K	L	S	F	L	R	L	I	S	N	E	S	E	Q	D	R	V	E	F	R	K	R	I	M	N	T	K	K	E	D	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T																													S					T													T	T															T
	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.	.	.	.	.	.	.	.	1090	.	.	.	.
Sequence	Y	K	F	A	D	L	L	E	S	K	V	N	E	F	E	K	N	I	V	I	I	T	T	K	E	K	A	N	E	Y	I	A	N	V	D	G	E	F	K	K	V	L	I	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										T					T	T																		T		T	T