PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3poyA_

Fold library id	PDB Header	Molecule	Title
c3poyA_	PDB header: cell adhesion	Chain: A: PDB Molecule: neurexin-1-alpha;	PDBTitle: crystal structure of the alpha-neurexin-1 ectodomain, lns 2-6

Links to external resources
Added to library: Sat Jun 11 12:31:39 2011

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence A A E E Y I A T F K G S E Y F C Y D L S Q N P I Q S S S D E I T L S F K T L Q R N G L M L H T G K S A D Y V N L A L K N G A V S L V I N L G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S S
T T S S
S
S
S T T
T T
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence S G A F E A L V E P V N G K F N D N A W H D V K V T R N L R Q V T I S V D G I L T T T G Y T Q E D Y T M L G S D D F F Y V G G S P S T A D L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S S
T T S S S
T T T T T
S T T
S S
S
S T T S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence P G S P V S N N F M G C L K E V V Y K N N D V R L E L S R L A K Q G D P K M K I H G V V A F K C E N V A T L D P I T F E T P E S F I S L P K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S
S
S S
T T S
S S
S T T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence W N A K K T G S I S F D F R T T E P N G L I L F S H G K P R H Q A K H P Q M I K V D F F A I E M L D G H L Y L L L D M G S G T I K I K A L Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S
S
S S
T T S S S
S
S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence K K V N D G E W Y H V D F Q R D G R S G T I S V N T L R T P Y T A P G E S E I L D L D D E L Y L G G L P E N K A G L V F P T E V W T A L L N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
T T S S
S S S
S
S S
T T
T T
S S
T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Y G Y V G C I R D L F I D G Q S K D I R Q M A E V Q S T A G V K P S C S R E T A K P C L S N P C K N N G M C R D G W N R Y V C D C S G T G Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
T T
T T
T T S
S S
G G G G
S S
S S S
T T T T

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence L G R S C E R E A T V L S Y D G S M F M K I Q L P V V M H T E A E D V S L R F R S Q R A Y G I L M A T T S R D S A D T L R L E L D A G R V K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T T S
S S
S
S
S B T T B
T T

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence L T V N L D C I K G P E T L F A G Y N L N D N E W H T V R V V R R G K S L K L T V D D Q Q A M T G Q M A G D H T R L E F H N I E T G I I T E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
S S S
T T T T S
S S
S S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence R R Y L S S V P S N F I G H L Q S L T F N G M A Y I D L C K N G D I D Y C E L N A R F G F R N I I A D P V T F K T K S S Y V A L A T L Q A Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S
T T B
T
S
S
S
S S S
S
S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence T S M H L F F Q F K T T S L D G L I L Y N S G D G N D F I V V E L V K G Y L H Y V F D L G N G A N L I K G S S N K P L N D N Q W H N V M I S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S
S
B S T T
T T S S S
S S
S
S S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence R D T S N L H T V K I D T K I T T Q I T A G A R N L D L K S D L Y I G G V A K E T Y K S L P K L V H A K E G F Q G C L A S V D L N G R L P D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T
B
S
S
T G G G G G S
T T
S S B
T T B

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence L I S D A L F C N G Q I E R G C E G P S T T C Q E D S C S N Q G V C L Q Q W D G F S C D C S M T S F S G P L C N D P G T T Y I F S K G G G Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S
S S
S S S S S
T T S S S T T
T T
T T T S
B S T T S
B

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence I T Y K W P P N D R P S T R A D R L A I G F S T V Q K E A V L V R V D S S S G L G D Y L E L H I H Q G K I G V K F N V G T D D I A I E E S N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G
B S
S S T T T
T T S S S S
S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence A I I N D G K Y H V V R F T R S G G N A T L Q V D S W P V I E R Y P A G R Q L T I F N S Q A T I I I G G K E Q G Q P F Q G Q L S G L Y Y N G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
T T T T S
S
B
S S G G G T
T T

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . .

Sequence L K V L N M A A E N D A N I A I V G N V R L L E V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) B
T T
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	A	A	E	E	Y	I	A	T	F	K	G	S	E	Y	F	C	Y	D	L	S	Q	N	P	I	Q	S	S	S	D	E	I	T	L	S	F	K	T	L	Q	R	N	G	L	M	L	H	T	G	K	S	A	D	Y	V	N	L	A	L	K	N	G	A	V	S	L	V	I	N	L	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S							S	S							T	T	S	S					S													S									S	T	T									T	T									S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	S	G	A	F	E	A	L	V	E	P	V	N	G	K	F	N	D	N	A	W	H	D	V	K	V	T	R	N	L	R	Q	V	T	I	S	V	D	G	I	L	T	T	T	G	Y	T	Q	E	D	Y	T	M	L	G	S	D	D	F	F	Y	V	G	G	S	P	S	T	A	D	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S										S	S	S		T	T	S	S	S										T	T							T	T	T								S	T	T								S					S			S		S	T	T	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	P	G	S	P	V	S	N	N	F	M	G	C	L	K	E	V	V	Y	K	N	N	D	V	R	L	E	L	S	R	L	A	K	Q	G	D	P	K	M	K	I	H	G	V	V	A	F	K	C	E	N	V	A	T	L	D	P	I	T	F	E	T	P	E	S	F	I	S	L	P	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S		S																	S	S														T	T					S				S	S														S	T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	W	N	A	K	K	T	G	S	I	S	F	D	F	R	T	T	E	P	N	G	L	I	L	F	S	H	G	K	P	R	H	Q	A	K	H	P	Q	M	I	K	V	D	F	F	A	I	E	M	L	D	G	H	L	Y	L	L	L	D	M	G	S	G	T	I	K	I	K	A	L	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S	S											S		S																	S	S														T	T								S	S	S							S		S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	K	K	V	N	D	G	E	W	Y	H	V	D	F	Q	R	D	G	R	S	G	T	I	S	V	N	T	L	R	T	P	Y	T	A	P	G	E	S	E	I	L	D	L	D	D	E	L	Y	L	G	G	L	P	E	N	K	A	G	L	V	F	P	T	E	V	W	T	A	L	L	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S				S	S											T	T							S	S								S	S	S								S					S	S			T	T		T	T					S	S							T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Y	G	Y	V	G	C	I	R	D	L	F	I	D	G	Q	S	K	D	I	R	Q	M	A	E	V	Q	S	T	A	G	V	K	P	S	C	S	R	E	T	A	K	P	C	L	S	N	P	C	K	N	N	G	M	C	R	D	G	W	N	R	Y	V	C	D	C	S	G	T	G	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		B											T	T												T	T		T	T			S						S	S		G	G	G	G					S	S							S	S	S						T	T	T	T
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	L	G	R	S	C	E	R	E	A	T	V	L	S	Y	D	G	S	M	F	M	K	I	Q	L	P	V	V	M	H	T	E	A	E	D	V	S	L	R	F	R	S	Q	R	A	Y	G	I	L	M	A	T	T	S	R	D	S	A	D	T	L	R	L	E	L	D	A	G	R	V	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	T	T	S											S	S														S											S		S									B	T	T	B										T	T
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	L	T	V	N	L	D	C	I	K	G	P	E	T	L	F	A	G	Y	N	L	N	D	N	E	W	H	T	V	R	V	V	R	R	G	K	S	L	K	L	T	V	D	D	Q	Q	A	M	T	G	Q	M	A	G	D	H	T	R	L	E	F	H	N	I	E	T	G	I	I	T	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																		S				S	S	S										T	T							T	T	S									S	S												S	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	R	R	Y	L	S	S	V	P	S	N	F	I	G	H	L	Q	S	L	T	F	N	G	M	A	Y	I	D	L	C	K	N	G	D	I	D	Y	C	E	L	N	A	R	F	G	F	R	N	I	I	A	D	P	V	T	F	K	T	K	S	S	Y	V	A	L	A	T	L	Q	A	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	S		S																T	T	B									T			S									S							S						S	S	S						S					S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	T	S	M	H	L	F	F	Q	F	K	T	T	S	L	D	G	L	I	L	Y	N	S	G	D	G	N	D	F	I	V	V	E	L	V	K	G	Y	L	H	Y	V	F	D	L	G	N	G	A	N	L	I	K	G	S	S	N	K	P	L	N	D	N	Q	W	H	N	V	M	I	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S											S		S									B	S	T	T									T	T								S	S	S										S	S		S		S	S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	R	D	T	S	N	L	H	T	V	K	I	D	T	K	I	T	T	Q	I	T	A	G	A	R	N	L	D	L	K	S	D	L	Y	I	G	G	V	A	K	E	T	Y	K	S	L	P	K	L	V	H	A	K	E	G	F	Q	G	C	L	A	S	V	D	L	N	G	R	L	P	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T								T	T															B		S					S				T	G	G	G	G	G	S		T	T				S	S	B											T	T	B
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	L	I	S	D	A	L	F	C	N	G	Q	I	E	R	G	C	E	G	P	S	T	T	C	Q	E	D	S	C	S	N	Q	G	V	C	L	Q	Q	W	D	G	F	S	C	D	C	S	M	T	S	F	S	G	P	L	C	N	D	P	G	T	T	Y	I	F	S	K	G	G	G	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	T	S		S				S					S	S	S	S	S						T	T	S	S	S	T	T							T	T							T	T	T	S		B	S	T	T	S		B
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	I	T	Y	K	W	P	P	N	D	R	P	S	T	R	A	D	R	L	A	I	G	F	S	T	V	Q	K	E	A	V	L	V	R	V	D	S	S	S	G	L	G	D	Y	L	E	L	H	I	H	Q	G	K	I	G	V	K	F	N	V	G	T	D	D	I	A	I	E	E	S	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							G	G	G				B	S													S										S	T	T	T										T	T								S	S	S	S								S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	A	I	I	N	D	G	K	Y	H	V	V	R	F	T	R	S	G	G	N	A	T	L	Q	V	D	S	W	P	V	I	E	R	Y	P	A	G	R	Q	L	T	I	F	N	S	Q	A	T	I	I	I	G	G	K	E	Q	G	Q	P	F	Q	G	Q	L	S	G	L	Y	Y	N	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S	S	S										T	T							T	T	S									S						B									S	S	G	G	G	T													T	T
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.
Sequence	L	K	V	L	N	M	A	A	E	N	D	A	N	I	A	I	V	G	N	V	R	L	L	E	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	B								T	T		T	T