PHYRE Protein Fold Recognition Server

Subscribe to Phyre at Google Groups

Email:

Visit Phyre at Google Groups

Follow @Phyre2server

Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3egyX_

Fold library id	PDB Header	Molecule	Title
c3egyX_	PDB header: transferase	Chain: X: PDB Molecule: thymidylate synthase;	PDBTitle: crystal structure of human thymidyalte synthase a191k with loop 181-2 197 stabilized in the inactive conformation

Links to external resources
Added to library: Thu Jan 10 05:38:42 2013

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence P P H G E L Q Y L G Q I Q H I L R G V R K D D R T G T G T L S V F G M Q A R Y S L R D E F P L L T T K R V F W K G V L E E L L W F I K G S T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T
T T
S S S
T T T T
T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence V Y G F Q W R H F G G V D Q L Q R V I D T I K T N P D D R R I I M A W N P R D L P L M K L P P H A L Q F Y V V N S E L S C Q L Y Q R S G D M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
B
T T
S
G G G T T T S S S
B
T T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence G L G V P F N I A S Y A L L T Y M I A H I T G L K P G D F I H T L G D A H I Y L N H I E P L K I Q L Q R E P R P F P K L R I L R K V E K I D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
G G G T T S
S
S G G

. . . . . . . . . 220 . . . . . . . . . 230

Sequence D F K A E D F Q I E G Y N P H P T I K M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G
G G G S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement
Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

Disclaimer

Terms and Conditions

Structural Biology Group logo Imperial logo

BBSRC logo
Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	P	P	H	G	E	L	Q	Y	L	G	Q	I	Q	H	I	L	R	G	V	R	K	D	D	R	T	G	T	G	T	L	S	V	F	G	M	Q	A	R	Y	S	L	R	D	E	F	P	L	L	T	T	K	R	V	F	W	K	G	V	L	E	E	L	L	W	F	I	K	G	S	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T																				T	T																	S	S	S					T	T	T	T																T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	V	Y	G	F	Q	W	R	H	F	G	G	V	D	Q	L	Q	R	V	I	D	T	I	K	T	N	P	D	D	R	R	I	I	M	A	W	N	P	R	D	L	P	L	M	K	L	P	P	H	A	L	Q	F	Y	V	V	N	S	E	L	S	C	Q	L	Y	Q	R	S	G	D	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									B			B														T	T		S								G	G	G	T	T	T	S	S	S				B							T	T													T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	G	L	G	V	P	F	N	I	A	S	Y	A	L	L	T	Y	M	I	A	H	I	T	G	L	K	P	G	D	F	I	H	T	L	G	D	A	H	I	Y	L	N	H	I	E	P	L	K	I	Q	L	Q	R	E	P	R	P	F	P	K	L	R	I	L	R	K	V	E	K	I	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T																					T																	G	G	G								T	T	S												S				S	G	G
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230
Sequence	D	F	K	A	E	D	F	Q	I	E	G	Y	N	P	H	P	T	I	K	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G			G	G	G					S