PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2e2xA_

Fold library id	PDB Header	Molecule	Title
c2e2xA_	PDB header: signaling protein	Chain: A: PDB Molecule: neurofibromin;	PDBTitle: sec14 homology module of neurofibromin in complex with2 phosphatitylethanolamine

Links to external resources
Added to library: Tue Mar 16 13:28:12 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence K T L S I F Y Q A G T S K A G N P I F Y Y V A R R F K T G Q I N G D L L I Y H V L L T L K P Y Y A K P Y E I V V D L T H T G P S N R F K T D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T B T T S
T T T
S S S S
T S
T T
G G G

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence F L S K W F V V F P G F A Y D N V S A V Y I Y N C N S W V R E Y T K Y H E R L L T G L K G S K R L V F I D C P G K L A E H I E H E Q Q K L P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S S
T S
T T T T G G G G T T
T T S S T T B G G G

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence A A T L A L E E D L K V F H N A L K L A H K D T K V S I K V G S T A V Q V T S A E R T K V L G Q S V F L N D I Y Y A S E I E E I C L V D E N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S S S S
T T S S
T T
G G G T T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250

Sequence Q F T L T I A N Q G T P L T F M H Q E C E A I V Q S I I H I R T R W E L S Q P D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S
T T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	K	T	L	S	I	F	Y	Q	A	G	T	S	K	A	G	N	P	I	F	Y	Y	V	A	R	R	F	K	T	G	Q	I	N	G	D	L	L	I	Y	H	V	L	L	T	L	K	P	Y	Y	A	K	P	Y	E	I	V	V	D	L	T	H	T	G	P	S	N	R	F	K	T	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T	T							B	T	T	S								T	T	T			S	S	S	S																		T	S									T	T			G	G	G
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	F	L	S	K	W	F	V	V	F	P	G	F	A	Y	D	N	V	S	A	V	Y	I	Y	N	C	N	S	W	V	R	E	Y	T	K	Y	H	E	R	L	L	T	G	L	K	G	S	K	R	L	V	F	I	D	C	P	G	K	L	A	E	H	I	E	H	E	Q	Q	K	L	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T	S	S	S							T								S												T	T	T	T	G	G	G	G	T	T		T	T					S	S						T	T	B	G	G	G
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	A	A	T	L	A	L	E	E	D	L	K	V	F	H	N	A	L	K	L	A	H	K	D	T	K	V	S	I	K	V	G	S	T	A	V	Q	V	T	S	A	E	R	T	K	V	L	G	Q	S	V	F	L	N	D	I	Y	Y	A	S	E	I	E	E	I	C	L	V	D	E	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	S	S											S	S	S										T	T							S	S					T	T											G	G	G									T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250
Sequence	Q	F	T	L	T	I	A	N	Q	G	T	P	L	T	F	M	H	Q	E	C	E	A	I	V	Q	S	I	I	H	I	R	T	R	W	E	L	S	Q	P	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	S		S							T	T																		T