PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2af6G_

Fold library id	PDB Header	Molecule	Title
c2af6G_	PDB header: transferase	Chain: G: PDB Molecule: thymidylate synthase thyx;	PDBTitle: crystal structure of mycobacterium tuberculosis flavin2 dependent thymidylate synthase (mtb thyx) in the presence3 of co-factor fad and substrate analog 5-bromo-2'-4 deoxyuridine-5'-monophosphate (brdump)

Links to external resources
Added to library: Tue Mar 16 13:57:24 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence E T A P L R V Q L I A K T D F L A P P D V P W T T D A D G G P A L V E F A G R A C Y Q S W S K P N P K T A T N A G Y L R H I X D V G H F S V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
T T S
S
T
S
G G G S S T T
G G G

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence L E H A S V S F Y I T G I S R S C T H E L I R H R H F S Y S Q L S Q R Y V P E K D S R V V V P P G X E D D A D L R H I L T E A A D A A R A T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G
T T
T T S
T T T S
T T
B
G G G S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence Y S E L L A K L E A K F A D Q P N A I L R R K Q A R Q A A R A V X P N A T E T R I V V T G N Y R A W R H F I A X R A S E H A D V E I R R L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
S
G G G
T T B S S T T S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . .

Sequence I E C L R Q L A A V A P A V F A D F E V T T L A D G T E V A T S P L A T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T S
T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	E	T	A	P	L	R	V	Q	L	I	A	K	T	D	F	L	A	P	P	D	V	P	W	T	T	D	A	D	G	G	P	A	L	V	E	F	A	G	R	A	C	Y	Q	S	W	S	K	P	N	P	K	T	A	T	N	A	G	Y	L	R	H	I	X	D	V	G	H	F	S	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		B																	T	T	S					S																	T			S				G	G	G	S	S											T	T		G	G	G
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	L	E	H	A	S	V	S	F	Y	I	T	G	I	S	R	S	C	T	H	E	L	I	R	H	R	H	F	S	Y	S	Q	L	S	Q	R	Y	V	P	E	K	D	S	R	V	V	V	P	P	G	X	E	D	D	A	D	L	R	H	I	L	T	E	A	A	D	A	A	R	A	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G																			T	T		T	T	S							T	T	T	S			T	T			B				G	G	G	S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	Y	S	E	L	L	A	K	L	E	A	K	F	A	D	Q	P	N	A	I	L	R	R	K	Q	A	R	Q	A	A	R	A	V	X	P	N	A	T	E	T	R	I	V	V	T	G	N	Y	R	A	W	R	H	F	I	A	X	R	A	S	E	H	A	D	V	E	I	R	R	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T	T		S														G	G	G			T	T	B																					S	S	T	T	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.
Sequence	I	E	C	L	R	Q	L	A	A	V	A	P	A	V	F	A	D	F	E	V	T	T	L	A	D	G	T	E	V	A	T	S	P	L	A	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																T	T							T	T	S							T	T