PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c1r7iB_

Fold library id	PDB Header	Molecule	Title
c1r7iB_	PDB header: oxidoreductase	Chain: B: PDB Molecule: 3-hydroxy-3-methylglutaryl-coenzyme a reductase;	PDBTitle: hmg-coa reductase from p. mevalonii, native structure at2 2.2 angstroms resolution.

Links to external resources
Added to library: Tue Mar 16 13:32:16 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence L D S R L P A F R N L S P A A R L D H I G Q L L G L S H D D V S L L A N A G A L P M D I A N G M I E N V I G T F E L P Y A V A S N F Q I N G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T G G G S
T T
S S
S
S S S
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence R D V L V P L V V E E P S I V A A A S Y M A K L A R A N G G F T T S S S A P L M H A Q V Q I V G I Q D P L N A R L S L L R R K D E I I E L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T T T T
B
S
S
T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence N R K D Q L L N S L G G G C R D I E V H T F A D T P R G P M L V A H L I V D V R D A M G A N T V N T M A E A V A P L M E A I T G G Q V R L R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
T
T T
T T S
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence I L S N L A D L R L A R A Q V R I T P Q Q L E T A E F S G E A V I E G I L D A Y A F A A V D P Y R A A T H N K G I M N G I D P L I V A T G N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T S
T T T T
S S S
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence D W R A V E A G A H A Y A C R S G H Y G S L T T W E K D N N G H L V G T L E M P M P V G L V G G A T K T H P L A Q L S L R I L G V K T A Q A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T S S
S
T T S
S S S T
T
S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . .

Sequence L A E I A V A V G L A Q N L G A M R A L A T E G I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	L	D	S	R	L	P	A	F	R	N	L	S	P	A	A	R	L	D	H	I	G	Q	L	L	G	L	S	H	D	D	V	S	L	L	A	N	A	G	A	L	P	M	D	I	A	N	G	M	I	E	N	V	I	G	T	F	E	L	P	Y	A	V	A	S	N	F	Q	I	N	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T	G	G	G	S													T	T											S	S			S									S	S	S																		T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	R	D	V	L	V	P	L	V	V	E	E	P	S	I	V	A	A	A	S	Y	M	A	K	L	A	R	A	N	G	G	F	T	T	S	S	S	A	P	L	M	H	A	Q	V	Q	I	V	G	I	Q	D	P	L	N	A	R	L	S	L	L	R	R	K	D	E	I	I	E	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										S		T	T														T	T	T		B																	S		S												T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	N	R	K	D	Q	L	L	N	S	L	G	G	G	C	R	D	I	E	V	H	T	F	A	D	T	P	R	G	P	M	L	V	A	H	L	I	V	D	V	R	D	A	M	G	A	N	T	V	N	T	M	A	E	A	V	A	P	L	M	E	A	I	T	G	G	Q	V	R	L	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	S								T															T	T													T	T	S																						S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	I	L	S	N	L	A	D	L	R	L	A	R	A	Q	V	R	I	T	P	Q	Q	L	E	T	A	E	F	S	G	E	A	V	I	E	G	I	L	D	A	Y	A	F	A	A	V	D	P	Y	R	A	A	T	H	N	K	G	I	M	N	G	I	D	P	L	I	V	A	T	G	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S			T	T	S										T	T	T	T			S	S	S																																									T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	D	W	R	A	V	E	A	G	A	H	A	Y	A	C	R	S	G	H	Y	G	S	L	T	T	W	E	K	D	N	N	G	H	L	V	G	T	L	E	M	P	M	P	V	G	L	V	G	G	A	T	K	T	H	P	L	A	Q	L	S	L	R	I	L	G	V	K	T	A	Q	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														T	T	T	S	S				S							T	T	S														S	S	S	T																T			S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.
Sequence	L	A	E	I	A	V	A	V	G	L	A	Q	N	L	G	A	M	R	A	L	A	T	E	G	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)