PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c1on3E_

Fold library id	PDB Header	Molecule	Title
c1on3E_	PDB header: transferase	Chain: E: PDB Molecule: methylmalonyl-coa carboxyltransferase 12s	PDBTitle: transcarboxylase 12s crystal structure: hexamer assembly2 and substrate binding to a multienzyme core (with3 methylmalonyl-coenzyme a and methylmalonic acid bound)

Links to external resources
Added to library: Tue Mar 16 13:29:08 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence N N L K L A S T M E G R V E Q L A E Q R Q V I E A G G G E R R V E K Q H S Q G K Q T A R E R L N N L L D P H S F D E V G A F R K H R T T L F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S T T T
T T
S
T T
T T
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence G M D K A V V P A D G V V T G R G T I L G R P V H A A S Q D F T V M G G S A G E T Q S T K V V E T M E Q A L L T G T P F L F F Y D S G G A R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T
G G G G T T
T T T G G G
B
T
S B

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence I Q E G I D S L S G Y G K M F F A N V K L S G V V P Q I A I I A G P C A G G A S Y S P A L T D F I I M T K K A H M F I T G P Q V I K S V T G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G T T T S
S G G G S S T T
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence E D V T A D E L G G A E A H M A I S G N I H F V A E D D D A A E L I A K K L L S F L P Q N N T E E A S F V N P N N D V S P N T E L R D I V P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B T T
S S S T S
S S T T S
S
T T S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence I D G K K G Y D V R D V I A K I V D W G D Y L E V K A G Y A T N L V T A F A R V N G R S V G I V A N Q P S V M S G C L D I N A S D K A A E F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S T T
T S G G G
S T T S S T T T T
T T T G G G
B

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence V N F C D S F N I P L V Q L V D V P G F L P G V Q Q E Y G G I I R H G A K M L Y A Y S E A T V P K I T V V L R K A Y G G S Y L A M C N R D L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
B
T T
S
T T T
G G G

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence G A D A V Y A W P S A E I A V M G A E G A A N V I F R K E I K A A D D P D A M R A E K I E E Y Q N A F N T P Y V A A A R G Q V D D V I D P A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S
T T
S S
S T S S S S S T T S S S
G G

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520

Sequence D T R R K I A S A L E M Y A T K R Q T R P A K K H G N F P C

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G G
S

Download: PDB structure FASTA sequence
Hidden Markov model

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	N	N	L	K	L	A	S	T	M	E	G	R	V	E	Q	L	A	E	Q	R	Q	V	I	E	A	G	G	G	E	R	R	V	E	K	Q	H	S	Q	G	K	Q	T	A	R	E	R	L	N	N	L	L	D	P	H	S	F	D	E	V	G	A	F	R	K	H	R	T	T	L	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							S	S																	T	T	T											T	T												S		T	T							T	T							T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	G	M	D	K	A	V	V	P	A	D	G	V	V	T	G	R	G	T	I	L	G	R	P	V	H	A	A	S	Q	D	F	T	V	M	G	G	S	A	G	E	T	Q	S	T	K	V	V	E	T	M	E	Q	A	L	L	T	G	T	P	F	L	F	F	Y	D	S	G	G	A	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	T	T				G	G	G	G									T	T										T	T	T	G	G	G		B																			T											S	B
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	I	Q	E	G	I	D	S	L	S	G	Y	G	K	M	F	F	A	N	V	K	L	S	G	V	V	P	Q	I	A	I	I	A	G	P	C	A	G	G	A	S	Y	S	P	A	L	T	D	F	I	I	M	T	K	K	A	H	M	F	I	T	G	P	Q	V	I	K	S	V	T	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G																			T	T	T	S												S	G	G	G						S	S						T	T					S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	E	D	V	T	A	D	E	L	G	G	A	E	A	H	M	A	I	S	G	N	I	H	F	V	A	E	D	D	D	A	A	E	L	I	A	K	K	L	L	S	F	L	P	Q	N	N	T	E	E	A	S	F	V	N	P	N	N	D	V	S	P	N	T	E	L	R	D	I	V	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										B							T	T				S				S	S														T	S		S	S	T	T	S						S									T	T					S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	I	D	G	K	K	G	Y	D	V	R	D	V	I	A	K	I	V	D	W	G	D	Y	L	E	V	K	A	G	Y	A	T	N	L	V	T	A	F	A	R	V	N	G	R	S	V	G	I	V	A	N	Q	P	S	V	M	S	G	C	L	D	I	N	A	S	D	K	A	A	E	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S	T	T					T								S	G	G	G						S	T	T	S	S	T	T									T	T										T	T	T	G	G	G		B
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	V	N	F	C	D	S	F	N	I	P	L	V	Q	L	V	D	V	P	G	F	L	P	G	V	Q	Q	E	Y	G	G	I	I	R	H	G	A	K	M	L	Y	A	Y	S	E	A	T	V	P	K	I	T	V	V	L	R	K	A	Y	G	G	S	Y	L	A	M	C	N	R	D	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T												B									T	T																	S																	T	T	T		G	G	G
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	G	A	D	A	V	Y	A	W	P	S	A	E	I	A	V	M	G	A	E	G	A	A	N	V	I	F	R	K	E	I	K	A	A	D	D	P	D	A	M	R	A	E	K	I	E	E	Y	Q	N	A	F	N	T	P	Y	V	A	A	A	R	G	Q	V	D	D	V	I	D	P	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T		S						T	T					S	S										S						T	S	S	S																	S	S							T	T	S	S	S					G	G
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520
Sequence	D	T	R	R	K	I	A	S	A	L	E	M	Y	A	T	K	R	Q	T	R	P	A	K	K	H	G	N	F	P	C
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G												G	G	G									S