PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c1jz6C_

Fold library id	PDB Header	Molecule	Title
c1jz6C_	PDB header: hydrolase	Chain: C: PDB Molecule: beta-galactosidase;	PDBTitle: e. coli (lacz) beta-galactosidase in complex with galacto-2 tetrazole

Links to external resources
Added to library: Tue Mar 16 12:00:08 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence R R D W E N P G V T Q L N R L A A H P P F A S W R N S E E A R T D R P S Q Q L R S L N G E W R F A W F P A P E A V P E S W L E C D L P E A D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G
T T
S S
S
B S S T
T T
S S G G G
T S
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence T V V V P S N W Q M H G Y D A P I Y T N V T Y P I T V N P P F V P T E N P T G C Y S L T F N V D E S W L Q E G Q T R I I F D G V N S A F H L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
T T T T T S S
S S S
S S
T T
S S
S S S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence W C N G R W V G Y G Q D S R L P S E F D L S A F L R A G E N R L A V M V L R W S D G S Y L E D Q D M W R M S G I F R D V S L L H K P T T Q I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T S
T T T
S S
G G G G G B
S
S
S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence S D F H V A T R F N D D F S R A V L E A E V Q M C G E L R D Y L R V T V S L W Q G E T Q V A S G T A P F G G E I I D E R G G Y A D R V T L R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S S S
T T T T
S
B T T B
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence L N V E N P K L W S A E I P N L Y R A V V E L H T A D G T L I E A E A C D V G F R E V R I E N G L L L L N G K P L L I R G V N R H E H H P L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
B B
S S S B
T T S
B
T T T T
B T T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence H G Q V M D E Q T M V Q D I L L M K Q N N F N A V R C S H Y P N H P L W Y T L C D R Y G L Y V V D E A N I E T H G M V P M N R L T D D P R W

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T B T
T T
T T S
T
S
B
T T S S S T T T T T T
G G G

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence L P A M S E R V T R M V Q R D R N H P S V I I W S L G N E S G H G A N H D A L Y R W I K S V D P S R P V Q Y E G G G A D T T A T D I I C P M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T
B S
T T S
T T T S
S T T
S S B
B

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence Y A R V D E D Q P F P A V P K W S I K K W L S L P G E T R P L I L C E Y A H A M G N S L G G F A K Y W Q A F R Q Y P R L Q G G F V W D W V D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
B
S S S
B
T T S T T
S
S S
T T
T T S
S B

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence Q S L I K Y D E N G N P W S A Y G G D F G D T P N D R Q F C M N G L V F A D R T P H P A L T E A K H Q Q Q F F Q F R L S G Q T I E V T S E Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T T T T S
S S
G G G G
S B
T T S
B
T T
S T T

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence L F R H S D N E L L H W M V A L D G K P L A S G E V P L D V A P Q G K Q L I E L P E L P Q P E S A G Q L W L T V R V V Q P N A T A W S E A G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S
T T
T T
T T
S S S
S
S S
T T

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence H I S A W Q Q W R L A E N L S V T L P A A S H A I P H L T T S E M D F C I E L G N K R W Q F N R Q S G F L S Q M W I G D K K Q L L T P L R D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
S S T T T T T S S T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Q F T R A P L D N D I G V S E A T R I D P N A W V E R W K A A G H Y Q A E A A L L Q C T A D T L A D A V L I T T A H A W Q H Q G K T L F I S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
B T T B
T T S T T T T
S S T T

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence R K T Y R I D G S G Q M A I T V D V E V A S D T P H P A R I G L N C Q L A Q V A E R V N W L G L G P Q E N Y P D R L T A A C F D R W D L P L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
T T S
S S
S S S
B T T B
S S
G

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence S D M Y T P Y V F P S E N G L R C G T R E L N Y G P H Q W R G D F Q F N I S R Y S Q Q Q L M E T S H R H L L H A E E G T W L N I D G F H M G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G
S S
S
T T S
S
G G G
S S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 .

Sequence I G G D D S W S P S V S A E F Q L S A G R Y H Y Q L V W C Q K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
S S S
G G G S
S S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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Phyre2 is part of Genome3D

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	R	R	D	W	E	N	P	G	V	T	Q	L	N	R	L	A	A	H	P	P	F	A	S	W	R	N	S	E	E	A	R	T	D	R	P	S	Q	Q	L	R	S	L	N	G	E	W	R	F	A	W	F	P	A	P	E	A	V	P	E	S	W	L	E	C	D	L	P	E	A	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			G	G	G		T	T		S			S						S					B	S	S							T				T	T														S	S	G	G	G			T					S			T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	T	V	V	V	P	S	N	W	Q	M	H	G	Y	D	A	P	I	Y	T	N	V	T	Y	P	I	T	V	N	P	P	F	V	P	T	E	N	P	T	G	C	Y	S	L	T	F	N	V	D	E	S	W	L	Q	E	G	Q	T	R	I	I	F	D	G	V	N	S	A	F	H	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S			T	T	T	T	T	S	S						S	S	S		S	S				T	T				S	S																			S	S							S				S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	W	C	N	G	R	W	V	G	Y	G	Q	D	S	R	L	P	S	E	F	D	L	S	A	F	L	R	A	G	E	N	R	L	A	V	M	V	L	R	W	S	D	G	S	Y	L	E	D	Q	D	M	W	R	M	S	G	I	F	R	D	V	S	L	L	H	K	P	T	T	Q	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T									T	T	S							T	T	T			S											S			G	G	G	G	G	B			S									S									S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	S	D	F	H	V	A	T	R	F	N	D	D	F	S	R	A	V	L	E	A	E	V	Q	M	C	G	E	L	R	D	Y	L	R	V	T	V	S	L	W	Q	G	E	T	Q	V	A	S	G	T	A	P	F	G	G	E	I	I	D	E	R	G	G	Y	A	D	R	V	T	L	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											T	T	S	S												S				T	T										T	T										S						B	T	T	B			T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	L	N	V	E	N	P	K	L	W	S	A	E	I	P	N	L	Y	R	A	V	V	E	L	H	T	A	D	G	T	L	I	E	A	E	A	C	D	V	G	F	R	E	V	R	I	E	N	G	L	L	L	L	N	G	K	P	L	L	I	R	G	V	N	R	H	E	H	H	P	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S			B	B		S	S	S	B												T	T	S												B							T	T					T	T														B	T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	H	G	Q	V	M	D	E	Q	T	M	V	Q	D	I	L	L	M	K	Q	N	N	F	N	A	V	R	C	S	H	Y	P	N	H	P	L	W	Y	T	L	C	D	R	Y	G	L	Y	V	V	D	E	A	N	I	E	T	H	G	M	V	P	M	N	R	L	T	D	D	P	R	W
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	B	T																	T	T							T	T	S														T								S		B		T	T	S	S	S	T	T	T	T	T	T		G	G	G
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	L	P	A	M	S	E	R	V	T	R	M	V	Q	R	D	R	N	H	P	S	V	I	I	W	S	L	G	N	E	S	G	H	G	A	N	H	D	A	L	Y	R	W	I	K	S	V	D	P	S	R	P	V	Q	Y	E	G	G	G	A	D	T	T	A	T	D	I	I	C	P	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																T	T		T	T								B	S																			T	T	S						T	T	T	S		S	T	T		S	S	B			B
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	Y	A	R	V	D	E	D	Q	P	F	P	A	V	P	K	W	S	I	K	K	W	L	S	L	P	G	E	T	R	P	L	I	L	C	E	Y	A	H	A	M	G	N	S	L	G	G	F	A	K	Y	W	Q	A	F	R	Q	Y	P	R	L	Q	G	G	F	V	W	D	W	V	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S			S	S			B			S	S	S		B							T	T	S	T	T											S				S	S			T	T												T	T							S		S	B
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	Q	S	L	I	K	Y	D	E	N	G	N	P	W	S	A	Y	G	G	D	F	G	D	T	P	N	D	R	Q	F	C	M	N	G	L	V	F	A	D	R	T	P	H	P	A	L	T	E	A	K	H	Q	Q	Q	F	F	Q	F	R	L	S	G	Q	T	I	E	V	T	S	E	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T								T	T	T	T	S		S	S			G	G	G	G				S	B		T	T	S		B		T									T		S							T	T
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	L	F	R	H	S	D	N	E	L	L	H	W	M	V	A	L	D	G	K	P	L	A	S	G	E	V	P	L	D	V	A	P	Q	G	K	Q	L	I	E	L	P	E	L	P	Q	P	E	S	A	G	Q	L	W	L	T	V	R	V	V	Q	P	N	A	T	A	W	S	E	A	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	S				T	T										T	T														T	T														S	S	S													S			S	S			T	T
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	H	I	S	A	W	Q	Q	W	R	L	A	E	N	L	S	V	T	L	P	A	A	S	H	A	I	P	H	L	T	T	S	E	M	D	F	C	I	E	L	G	N	K	R	W	Q	F	N	R	Q	S	G	F	L	S	Q	M	W	I	G	D	K	K	Q	L	L	T	P	L	R	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																							S									S	S							T	T							T	T	T	S	S							T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Q	F	T	R	A	P	L	D	N	D	I	G	V	S	E	A	T	R	I	D	P	N	A	W	V	E	R	W	K	A	A	G	H	Y	Q	A	E	A	A	L	L	Q	C	T	A	D	T	L	A	D	A	V	L	I	T	T	A	H	A	W	Q	H	Q	G	K	T	L	F	I	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T		B	T	T	B			T	T	S									T	T	T	T														S	S													T	T
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	R	K	T	Y	R	I	D	G	S	G	Q	M	A	I	T	V	D	V	E	V	A	S	D	T	P	H	P	A	R	I	G	L	N	C	Q	L	A	Q	V	A	E	R	V	N	W	L	G	L	G	P	Q	E	N	Y	P	D	R	L	T	A	A	C	F	D	R	W	D	L	P	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T	S												T	T	S				S									S				S									S	S			B	T	T	B		S	S										G
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	S	D	M	Y	T	P	Y	V	F	P	S	E	N	G	L	R	C	G	T	R	E	L	N	Y	G	P	H	Q	W	R	G	D	F	Q	F	N	I	S	R	Y	S	Q	Q	Q	L	M	E	T	S	H	R	H	L	L	H	A	E	E	G	T	W	L	N	I	D	G	F	H	M	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G					S	S			S													T	T													S										S		G	G	G					S	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.
Sequence	I	G	G	D	D	S	W	S	P	S	V	S	A	E	F	Q	L	S	A	G	R	Y	H	Y	Q	L	V	W	C	Q	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S		S	S	S					G	G	G	S			S	S