Email l.a.kelley@imperial.ac.uk Description C6Y4C6 Date Sun Jul 8 11:45:09 BST 2012 Unique Job ID f1c3c8c5225570b3

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template d1lujb_ Top template information Fold:beta-catenin-interacting protein ICAT Superfamily:beta-catenin-interacting protein ICAT Family:beta-catenin-interacting protein ICAT Confidence and coverage Confidence: 15.1% Coverage: 46% 53 residues ( 46% of your sequence) have been modelled with 15.1% confidence by the single highest scoring template. You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library. Please note: You must be registered and logged in to use Phyrealarm. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1luj chain B Region: 36 - 92 Aligned: 53 Modelled: 57 Confidence: 15.1% Identity: 21% Fold: beta-catenin-interacting protein ICAT Superfamily: beta-catenin-interacting protein ICAT Family: beta-catenin-interacting protein ICAT Phyre2 PDB 3bzk chain A domain 2 Region: 36 - 43 Aligned: 8 Modelled: 8 Confidence: 12.4% Identity: 63% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Tex HhH-containing domain-like Phyre2 PDB 2pag chain A domain 1 Region: 47 - 81 Aligned: 35 Modelled: 35 Confidence: 10.7% Identity: 26% Fold: SMI1/KNR4-like Superfamily: SMI1/KNR4-like Family: SMI1/KNR4-like Phyre2 PDB 1yua chain A domain 2 Region: 30 - 44 Aligned: 15 Modelled: 15 Confidence: 10.3% Identity: 53% Fold: Rubredoxin-like Superfamily: Zinc beta-ribbon Family: Prokaryotic DNA topoisomerase I, a C-terminal fragment Phyre2 PDB 2qyx chain B Region: 79 - 110 Aligned: 32 Modelled: 32 Confidence: 9.9% Identity: 13% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein mj0159; PDBTitle: crystal structure of uncharacterized protein mj0159 from2 methanocaldococcus jannaschii Phyre2 PDB 3pzd chain B Region: 66 - 89 Aligned: 24 Modelled: 24 Confidence: 9.8% Identity: 33% PDB header:motor protein/apoptosis Chain: B: PDB Molecule:netrin receptor dcc; PDBTitle: structure of the myosin x myth4-ferm/dcc complex Phyre2 PDB 3mx3 chain B Region: 36 - 54 Aligned: 19 Modelled: 19 Confidence: 8.6% Identity: 11% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:susd homolog; PDBTitle: crystal structure of a susd homolog (bf0972) from bacteroides fragilis2 nctc 9343 at 2.00 a resolution Phyre2 PDB 3f1j chain A Region: 15 - 33 Aligned: 19 Modelled: 19 Confidence: 8.3% Identity: 42% PDB header:viral protein Chain: A: PDB Molecule:matrix protein; PDBTitle: crystal structure of the borna disease virus matrix protein2 (bdv-m) reveals rna binding properties Phyre2 PDB 1lg4 chain A Region: 37 - 53 Aligned: 16 Modelled: 17 Confidence: 7.9% Identity: 25% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 PDB 2ip6 chain A Region: 18 - 54 Aligned: 35 Modelled: 37 Confidence: 7.7% Identity: 29% PDB header:antimicrobial protein Chain: A: PDB Molecule:papb; PDBTitle: crystal structure of pedb Phyre2 PDB 2r26 chain C Region: 27 - 79 Aligned: 44 Modelled: 53 Confidence: 7.7% Identity: 23% PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: the structure of the ternary complex of carboxymethyl2 coenzyme a and oxalateacetate with citrate synthase from3 the thermophilic archaeonthermoplasma acidophilum Phyre2 PDB 3l4g chain I Region: 29 - 46 Aligned: 18 Modelled: 18 Confidence: 7.4% Identity: 28% PDB header:ligase Chain: I: PDB Molecule:phenylalanyl-trna synthetase alpha chain; PDBTitle: crystal structure of homo sapiens cytoplasmic phenylalanyl-trna2 synthetase Phyre2 PDB 1jqs chain B Region: 63 - 78 Aligned: 16 Modelled: 16 Confidence: 7.3% Identity: 44% PDB header:ribosome Chain: B: PDB Molecule:elongation factor g; PDBTitle: fitting of l11 protein and elongation factor g (domain g'2 and v) in the cryo-em map of e. coli 70s ribosome bound3 with ef-g and gmppcp, a nonhydrolysable gtp analog Phyre2 PDB 3cgh chain A domain 1 Region: 36 - 54 Aligned: 19 Modelled: 19 Confidence: 7.2% Identity: 21% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: SusD-like Phyre2 PDB 1dp3 chain A Region: 49 - 69 Aligned: 21 Modelled: 21 Confidence: 7.1% Identity: 19% Fold: IHF-like DNA-binding proteins Superfamily: IHF-like DNA-binding proteins Family: DNA-binding domain (fragment?) of the TraM protein Phyre2 PDB 1zs3 chain A domain 1 Region: 43 - 77 Aligned: 35 Modelled: 35 Confidence: 6.5% Identity: 9% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ferritin Phyre2 PDB 1ty0 chain A domain 2 Region: 65 - 102 Aligned: 36 Modelled: 38 Confidence: 6.2% Identity: 31% Fold: beta-Grasp (ubiquitin-like) Superfamily: Superantigen toxins, C-terminal domain Family: Superantigen toxins, C-terminal domain Phyre2 PDB 1vl2 chain A domain 2 Region: 20 - 34 Aligned: 15 Modelled: 15 Confidence: 5.8% Identity: 33% Fold: Argininosuccinate synthetase, C-terminal domain Superfamily: Argininosuccinate synthetase, C-terminal domain Family: Argininosuccinate synthetase, C-terminal domain Phyre2 PDB 2dym chain E Region: 1 - 29 Aligned: 28 Modelled: 29 Confidence: 5.4% Identity: 29% PDB header:protein turnover/protein turnover Chain: E: PDB Molecule:autophagy protein 5; PDBTitle: the crystal structure of saccharomyces cerevisiae atg5-2 atg16(1-46) complex Phyre2 PDB 3ejn chain A domain 1 Region: 36 - 54 Aligned: 19 Modelled: 19 Confidence: 5.1% Identity: 16% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: SusD-like Phyre2 1 d1lujb_ 2 d3bzka2 3 d2paga1 4 d1yuaa2 5 c2qyxB_ 6 c3pzdB_ 7 c3mx3B_ 8 c3f1jA_ 9 d1lg4a_ 10 c2ip6A_ 11 c2r26C_ 12 c3l4gI_ 13 c1jqsB_ 14 d3cgha1 15 d1dp3a_ 16 d1zs3a1 17 d1ty0a2 18 d1vl2a2 19 c2dymE_ 20 d3ejna1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0