Phyre 2 Results for O13555

Email	l.a.kelley@imperial.ac.uk
Description	O13555
Date	Mon Jul 2 19:10:14 BST 2012
Unique Job ID	9531495f7b1372e2

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c4aoyD_

Top template information

PDB header:oxidoreductase
Chain: D: PDB Molecule:isocitrate dehydrogenase [nadp];
PDBTitle: open ctidh. the complex structures of isocitrate dehydrogenase from2 clostridium thermocellum and desulfotalea psychrophila, support a3 new active site locking mechanism

Confidence and coverage

Confidence:

14.8%

Coverage:

25%

31 residues ( 25% of your sequence) have been modelled with 14.8% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

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3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M E K D E E D E E S E E A E E E L L V L E S D E K L N D V N D M E A M L V D E L V C D T R D L L D V D E V R E D E S A L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
?
?
? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence E E E T I L D D K M E L E E L T L L T E E R A V D T A E E F E D D D C T K N C A R I V D M H D S I K S N K R K L F L V V

Secondary structure

SS confidence

Disorder ?
?
? ?
?
? ? ?
?
?

Disorder confidence

. . . . .

Sequence K D N I L

Secondary structure

SS confidence

Disorder ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 4aoy chain D

Region: 95 - 125
Aligned: 31
Modelled: 31
Confidence: 14.8%
Identity: 16%
PDB header:oxidoreductase
Chain: D: PDB Molecule:isocitrate dehydrogenase [nadp];
PDBTitle: open ctidh. the complex structures of isocitrate dehydrogenase from2 clostridium thermocellum and desulfotalea psychrophila, support a3 new active site locking mechanism

Phyre2

PDB 3us8 chain A

Region: 97 - 125
Aligned: 29
Modelled: 29
Confidence: 12.2%
Identity: 17%
PDB header:oxidoreductase
Chain: A: PDB Molecule:isocitrate dehydrogenase [nadp];
PDBTitle: crystal structure of an isocitrate dehydrogenase from sinorhizobium2 meliloti 1021

Phyre2

PDB 2uxq chain B

Region: 97 - 125
Aligned: 29
Modelled: 29
Confidence: 10.8%
Identity: 14%
PDB header:oxidoreductase
Chain: B: PDB Molecule:isocitrate dehydrogenase native;
PDBTitle: isocitrate dehydrogenase from the psychrophilic bacterium2 desulfotalea psychrophila: biochemical properties and3 crystal structure analysis

Phyre2

PDB 1t0l chain A

Region: 97 - 125
Aligned: 29
Modelled: 29
Confidence: 10.5%
Identity: 24%
Fold: Isocitrate/Isopropylmalate dehydrogenase-like
Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like
Family: Dimeric isocitrate & isopropylmalate dehydrogenases

Phyre2

PDB 2qfy chain E

Region: 97 - 125
Aligned: 29
Modelled: 29
Confidence: 9.9%
Identity: 24%
PDB header:oxidoreductase
Chain: E: PDB Molecule:isocitrate dehydrogenase [nadp];
PDBTitle: crystal structure of saccharomyces cerevesiae mitochondrial nadp(+)-2 dependent isocitrate dehydrogenase in complex with a-ketoglutarate

Phyre2

PDB 1lwd chain A

Region: 97 - 125
Aligned: 29
Modelled: 29
Confidence: 8.0%
Identity: 17%
Fold: Isocitrate/Isopropylmalate dehydrogenase-like
Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like
Family: Dimeric isocitrate & isopropylmalate dehydrogenases

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	E	K	D	E	E	D	E	E	S	E	E	A	E	E	E	L	L	V	L	E	S	D	E	K	L	N	D	V	N	D	M	E	A	M	L	V	D	E	L	V	C	D	T	R	D	L	L	D	V	D	E	V	R	E	D	E	S	A	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?							?													?		?	?																										?	?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	E	E	E	T	I	L	D	D	K	M	E	L	E	E	L	T	L	L	T	E	E	R	A	V	D	T	A	E	E	F	E	D	D	D	C	T	K	N	C	A	R	I	V	D	M	H	D	S	I	K	S	N	K	R	K	L	F	L	V	V
Secondary structure
SS confidence
Disorder	?			?		?	?															?		?	?	?						?																?
Disorder confidence

	.	.	.	.	.
Sequence	K	D	N	I	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?
Disorder confidence