rank | freq. | Superfamily | Fold | Class |
---|---|---|---|---|

1 | 20 | P-loop containing nucleotide triphosphate hydrolases | P-loop containing nucleotide triphosphate hydrolases | Alpha and beta (a/b) |

2 | 10 | Class II aaRS and biotin synthetases | Class II aaRS and biotin synthetases | Alpha and beta (a+b) |

3 | 9 | Nucleic acid-binding proteins | OB-fold | All beta |

4 | 8 | Class I aminoacyl-tRNA synthetases (RS), catalytic domain | Adenine nucleotide alpha hydrolase | Alpha and beta (a/b) |

4 | 8 | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | Alpha and beta (a/b) |

6 | 4 | An anticodon-binding domain of Class II aaRS | An anticodon-binding domain of Class II aaRS | Alpha and beta (a/b) |

6 | 4 | alpha/beta-Hydrolases | alpha/beta-Hydrolases | Alpha and beta (a/b) |

6 | 4 | Thiamin-binding | Thiamin-binding | Alpha and beta (a/b) |

6 | 4 | actin-like ATPase domain | Ribonuclease H-like motif | Alpha and beta (a/b) |

6 | 4 | adenine nucleotide alpha hydrolases | Adenine nucleotide alpha hydrolase | Alpha and beta (a/b) |

11 | 3 | Chaperone J-domain | Long alpha-hairpin | All alpha |

11 | 3 | Translation factors | Reductase/isomerase/elongation factor common domain | All beta |

11 | 3 | DNA clamp | DNA clamp | Alpha and beta (a+b) |

11 | 3 | S-adenosylmethionine synthetase. MAT | S-adenosylmethionine synthetase. MAT | Alpha and beta (a+b) |

11 | 3 | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | Alpha and beta (a/b) |

11 | 3 | Elongation factor Tu (EF-Tu), the C-terminal domain | Elongation factor Tu (EF-Tu), the C-terminal domain | All beta |

11 | 3 | Phosphoribosyltransferases (PRTases) | Phosphoribosyltransferases (PRTases) | Alpha and beta (a/b) |

11 | 3 | Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | Alpha and beta (a/b) |

11 | 3 | NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | Alpha and beta (a/b) |

20 | 2 | Glutathione synthetase ATP-binding domain-like | ATP-grasp | Alpha and beta (a+b) |

20 | 2 | Biotin carboxylase N-terminal domain-like | Biotin carboxylase N-terminal domain-like | Alpha and beta (a/b) |

20 | 2 | type II DNA topoisomerase | type II DNA topoisomerase | Multi-domain (alpha and beta) |

20 | 2 | Transketolase, C-terminal domain | Transketolase, C-terminal domain | Alpha and beta (a/b) |

20 | 2 | Zn metallo-beta-lactamase | Zn metallo-beta-lactamase | Alpha and beta (a+b) |

20 | 2 | The N-terminal domain of alpha and beta subunits of F1 ATP synthase | A domain of alpha and beta subunits of F1 ATP synthase-like | All beta |

20 | 2 | The C-terminal domain of alpha and beta subunits of F1 ATP synthase | Left-handed superhelix | All alpha |

20 | 2 | Creatinase/methionine aminopeptidase | Creatinase/methionine aminopeptidase | Alpha and beta (a+b) |

20 | 2 | Dihydrofolate reductases | Dihydrofolate reductases | Alpha and beta (a/b) |

20 | 2 | Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | Alpha and beta (a+b) |

20 | 2 | Elongation factor G (EF-G), domain V | Ferredoxin-like | Alpha and beta (a+b) |

20 | 2 | Elongation factor Ts (EF-Ts), dimerisation domain | Elongation factor Ts (EF-Ts), dimerisation domain | Alpha and beta (a+b) |

20 | 2 | PLP-dependent transferases | PLP-dependent transferases | Alpha and beta (a/b) |

20 | 2 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | Alpha and beta (a+b) |

20 | 2 | Phosphoenolpyruvate/pyruvate domain | beta/alpha (TIM)-barrel | Alpha and beta (a/b) |

20 | 2 | Membrane all-alpha | Membrane all-alpha | Membrane and cell surface proteins and peptides |

36 | 1 | Tyrosyl-tRNA synthetase, middle domain | Tyrosyl-tRNA synthetase, middle domain | All alpha |

36 | 1 | GreA transcript cleavage factor, C-terminal domain | FKBP-like | Alpha and beta (a+b) |

36 | 1 | Zn-dependent exopeptidases | Phosphorylase/hydrolase-like | Alpha and beta (a/b) |

36 | 1 | ATP syntase (F1-ATPase), gamma subunit | ATP syntase (F1-ATPase), gamma subunit | All alpha |

36 | 1 | GroEL, the ATPase domain | GroEL, the ATPase domain | All alpha |

36 | 1 | GroES-like | GroES-like | All beta |

36 | 1 | GreA transcript cleavage protein, N-terminal domain | Long alpha-hairpin | All alpha |

36 | 1 | Histidine-containing phosphocarrier proteins (HPr) | Histidine-containing phosphocarrier proteins (HPr) | Alpha and beta (a+b) |

36 | 1 | HIT-like | HIT-like | Alpha and beta (a+b) |

36 | 1 | Inorganic pyrophosphatase | OB-fold | All beta |

36 | 1 | Lactate & malate dehydrogenases, C-terminal domain | Lactate & malate dehydrogenases, C-terminal domain | Alpha and beta (a+b) |

36 | 1 | A nucleotide-binding domain | A nucleotide-binding domain | Alpha and beta (a/b) |

36 | 1 | N-terminal domain of enolase & muconate-lactonizing enzyme | N-terminal domain of enolase & muconate-lactonizing enzyme | Alpha and beta (a+b) |

36 | 1 | N-terminal domain of the delta subunit of the F1F0-ATP synthase | N-terminal domain of the delta subunit of the F1F0-ATP synthase | All alpha |

36 | 1 | GMP synthetase, the C-terminal, dimerisation domain | GMP synthetase, the C-terminal, dimerisation domain | Alpha and beta (a+b) |

36 | 1 | Glycinamide ribonucleotide transformylase | Glycinamide ribonucleotide transformylase | Alpha and beta (a/b) |

36 | 1 | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | Alpha and beta (a+b) |

36 | 1 | Peptide deformylase catalytic core | Peptide deformylase catalytic core | Alpha and beta (a+b) |

36 | 1 | Periplasmic binding protein-like II | Periplasmic binding protein-like II | Alpha and beta (a/b) |

36 | 1 | Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain | Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain | All beta |

36 | 1 | Phosphofructokinase | Phosphofructokinase | Alpha and beta (a/b) |

36 | 1 | Ferritin-like | Ferritin-like | All alpha |

36 | 1 | Phosphoglucomutase, the C-terminal domain | TBP-like | Alpha and beta (a+b) |

36 | 1 | Phosphoglycerate kinase | Phosphoglycerate kinase | Alpha and beta (a/b) |

36 | 1 | Acyl-carrier protein (ACP) | Acyl carrier protein-like | All alpha |

36 | 1 | FAD-linked reductases, C-terminal domain | FAD-linked reductases, C-terminal domain | Alpha and beta (a+b) |

36 | 1 | Enolase & muconate-lactonizing enzyme, C-terminal domain | beta/alpha (TIM)-barrel | Alpha and beta (a/b) |

36 | 1 | Protein kinases (PK), catalytic core | Protein kinases (PK), catalytic core | Multi-domain (alpha and beta) |

36 | 1 | Purine and uridine phosphorylases | Phosphorylase/hydrolase-like | Alpha and beta (a/b) |

36 | 1 | Pyruvate kinase beta-barrel domain | Pyruvate kinase beta-barrel domain | All beta |

36 | 1 | CoA-dependent acetyltransferases | CoA-dependent acetyltransferases | Alpha and beta (a/b) |

36 | 1 | R1 subunit of ribonucleotide reductase, C-terminal domain | R1 subunit of ribonucleotide reductase, C-terminal domain | Alpha and beta (a/b) |

36 | 1 | R1 subunit of ribonucleotide reductase, N-terminal domain | R1 subunit of ribonucleotide reductase, N-terminal domain | All alpha |

36 | 1 | RecA protein, C-terminal domain | Anti-LPS factor/recA domain | Alpha and beta (a+b) |

36 | 1 | Ribosomal protein L1 | Ribosomal protein L1 | Multi-domain (alpha and beta) |

36 | 1 | Ribosomal protein L11, the C-terminal domain | DNA-binding 3-helical bundle | All alpha |

36 | 1 | Ribosomal protein L14 | Ribosomal protein L14 | All beta |

36 | 1 | Ribosomal protein L7/12, C-terminal fragment | Ribosomal protein L7/12, C-terminal fragment | Alpha and beta (a+b) |

36 | 1 | Ribosomal protein S15 from | Ribosomal protein S15 from | All alpha |

36 | 1 | Duplicated hybrid motif | Barrel-sandwich hybrid | All beta |

36 | 1 | Ribosomal protein S6 | Ferredoxin-like | Alpha and beta (a+b) |

36 | 1 | Ribosomal protein S8 | Ribosomal protein S8 | Alpha and beta (a+b) |

36 | 1 | DNA helicase RuvA subunit, the middle domain | DNA helicase RuvA subunit, the middle domain | All alpha |

36 | 1 | DNA helicase RuvA subunit, C-terminal domain | DNA helicase RuvA subunit, C-terminal domain | All alpha |

36 | 1 | Single hybrid motif | Barrel-sandwich hybrid | All beta |

36 | 1 | Cytidine deaminase | Cytidine deaminase | Alpha and beta (a/b) |

36 | 1 | Creatinase, N-terminal domain | Ribonuclease H-like motif | Alpha and beta (a/b) |

36 | 1 | the C-terminal domain of RNA polymerase alpha subunit | the C-terminal domain of RNA polymerase alpha subunit | All alpha |

36 | 1 | The coiled-coil domain of nucleotide exchange factor GrpE | Oligomers of long helices | All alpha |

36 | 1 | The head domain of nucleotide exchange factor GrpE | The head domain of nucleotide exchange factor GrpE | All beta |

36 | 1 | The intermediate domain of GroEL | The intermediate domain of GroEL | Alpha and beta (a+b) |

36 | 1 | A sigma70 subunit fragment from RNA polymerase | A sigma70 subunit fragment from RNA polymerase | All alpha |

36 | 1 | Uracil-DNA glycosylase | Uracil-DNA glycosylase | Alpha and beta (a/b) |

36 | 1 | Thioredoxin-like | Thioredoxin fold | Alpha and beta (a/b) |

36 | 1 | Thymidylate synthase | Thymidylate synthase | Alpha and beta (a+b) |

36 | 1 | 5' to 3' exonuclease | 5' to 3' exonuclease | Alpha and beta (a/b) |

36 | 1 | type I DNA topoisomerase | type I DNA topoisomerase | Multi-domain (alpha and beta) |

36 | 1 | Translation initiation factor IF3 | IF3-like | Alpha and beta (a+b) |

36 | 1 | Translation initiation factor IF3, N-terminal domain | beta-Grasp | Alpha and beta (a+b) |

36 | 1 | Triosephosphate isomerase (TIM) | beta/alpha (TIM)-barrel | Alpha and beta (a/b) |

36 | 1 | Phosphohistidine domain | The "swivelling" beta/beta/alpha domain | Alpha and beta (a/b) |

36 | 1 | Flavoproteins | Flavodoxin-like | Alpha and beta (a/b) |

36 | 1 | Heat shock protein 70kD (HSP70), C-terminal, substrate-binding fragment | Heat shock protein 70kD (HSP70), C-terminal, substrate-binding fragment | Multi-domain (alpha and beta) |

36 | 1 | Pyruvate kinase, C-terminal domain | Pyruvate kinase, C-terminal domain | Alpha and beta (a/b) |

36 | 1 | Class II aldolases | beta/alpha (TIM)-barrel | Alpha and beta (a/b) |

36 | 1 | the apical domain of GroEL | The "swivelling" beta/beta/alpha domain | Alpha and beta (a/b) |

36 | 1 | Xylose isomerase | beta/alpha (TIM)-barrel | Alpha and beta (a/b) |

Copyright © 1999-2002 Cancer Research UK

All Rights Reserved, disclaimer

Comments to author: a.mueller@cancer.org.uk

Generated: Thu Jun 27, 2002