Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	S	D	K	V	L	N	L	P	A	G	Y	F	G	I	V	L	G	T	I	G	M	G	F	A	W	R	Y	A	S	Q	V	W	Q	V	S	H	W	L	G	D	G	L	V	I	L	A	M	I	I	W	G	L	L	T	S	A	F	I
Secondary structure
SS confidence
Disorder		?	?	?			?	?																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	R	L	I	R	F	P	H	S	V	L	A	E	V	R	H	P	V	L	S	S	F	V	S	L	F	P	A	T	T	M	L	V	A	I	G	F	V	P	W	F	R	P	L	A	V	C	L	F	S	F	G	V	V	V	Q	L	A	Y	A
Secondary structure
SS confidence
Disorder																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	W	Q	T	A	G	L	W	R	G	S	H	P	E	E	A	T	T	P	G	L	Y	L	P	T	V	A	N	N	F	I	S	A	M	A	C	G	A	L	G	Y	T	D	A	G	L	V	F	L	G	A	G	V	F	S	W	L	S	L	E
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?																		?		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	V	I	L	Q	R	L	R	S	S	G	E	L	P	T	A	L	R	T	S	L	G	I	Q	L	A	P	A	L	V	A	C	S	A	W	L	S	V	N	G	G	E	G	D	T	L	A	K	M	L	F	G	Y	G	L	L	Q	L	L	F
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		M	L	R	L	M	P	W	Y	L	S	Q	P	F	N	A	S	F	W	S	F	S	F	G	V	S	A	L	A	T	T	G	L	H	L	G	S	G	S	D	N	G	F	F	H	T	L	A	V	P	L	F	I	F	T	N	F	I	I	A	I
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330
Sequence		L	L	I	R	T	F	A	L	L	M	Q	G	K	L	L	V	R	T	E	R	A	V	L	M	K	A	E	D	K	E
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3m7b chain A Region: 9 - 316 Aligned: 304 Modelled: 305 Confidence: 100.0% Identity: 40% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha Phyre2 PDB 2knc chain A Region: 275 - 327 Aligned: 50 Modelled: 53 Confidence: 12.1% Identity: 10% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 3kys chain B Region: 5 - 14 Aligned: 10 Modelled: 10 Confidence: 8.9% Identity: 30% PDB header:transcription/protein binding Chain: B: PDB Molecule:65 kda yes-associated protein; PDBTitle: crystal structure of human yap and tead complex Phyre2 PDB 1cn3 chain F Region: 135 - 146 Aligned: 12 Modelled: 12 Confidence: 8.3% Identity: 33% PDB header:viral protein Chain: F: PDB Molecule:fragment of coat protein vp2; PDBTitle: interaction of polyomavirus internal protein vp2 with major2 capsid protein vp1 and implications for participation of3 vp2 in viral entry Phyre2 PDB 3dww chain A Region: 288 - 330 Aligned: 43 Modelled: 43 Confidence: 7.0% Identity: 12% PDB header:isomerase Chain: A: PDB Molecule:prostaglandin e synthase; PDBTitle: electron crystallographic structure of human microsomal2 prostaglandin e synthase 1 Phyre2 PDB 3kcq chain A Region: 301 - 330 Aligned: 30 Modelled: 30 Confidence: 6.3% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:phosphoribosylglycinamide formyltransferase; PDBTitle: crystal structure of phosphoribosylglycinamide formyltransferase from2 anaplasma phagocytophilum Phyre2 PDB 1i25 chain A Region: 322 - 329 Aligned: 8 Modelled: 8 Confidence: 5.9% Identity: 38% PDB header:toxin Chain: A: PDB Molecule:huwentoxin-ii; PDBTitle: three dimensional solution structure of huwentoxin-ii by 2d2 1h-nmr Phyre2 PDB 1i25 chain A Region: 322 - 329 Aligned: 8 Modelled: 8 Confidence: 5.9% Identity: 38% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 1xio chain A Region: 173 - 313 Aligned: 140 Modelled: 141 Confidence: 5.8% Identity: 8% Fold: Family A G protein-coupled receptor-like Superfamily: Family A G protein-coupled receptor-like Family: Bacteriorhodopsin-like Phyre2 PDB 1xio chain A Region: 173 - 313 Aligned: 140 Modelled: 141 Confidence: 5.8% Identity: 8% PDB header:signaling protein Chain: A: PDB Molecule:anabaena sensory rhodopsin; PDBTitle: anabaena sensory rhodopsin Phyre2 PDB 4cro chain A Region: 311 - 330 Aligned: 20 Modelled: 20 Confidence: 5.5% Identity: 15% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: Phage repressors Phyre2 PDB 2rm9 chain A Region: 322 - 330 Aligned: 9 Modelled: 9 Confidence: 5.4% Identity: 22% PDB header:neuropeptide Chain: A: PDB Molecule:astressin2b; PDBTitle: astressin2b Phyre2 1 c3m7bA_ 2 c2kncA_ 3 c3kysB_ 4 c1cn3F_ 5 c3dwwA_ 6 c3kcqA_ 7 c1i25A_ 8 d1i25a_ 9 d1xioa_ 10 c1xioA_ 11 d4croa_ 12 c2rm9A_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3m7bA_ 100.0 40 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha 2 c2kncA_ 12.1 10 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 3 c3kysB_ 8.9 30 PDB header:transcription/protein binding Chain: B: PDB Molecule:65 kda yes-associated protein; PDBTitle: crystal structure of human yap and tead complex 4 c1cn3F_ 8.3 33 PDB header:viral protein Chain: F: PDB Molecule:fragment of coat protein vp2; PDBTitle: interaction of polyomavirus internal protein vp2 with major2 capsid protein vp1 and implications for participation of3 vp2 in viral entry 5 c3dwwA_ 7.0 12 PDB header:isomerase Chain: A: PDB Molecule:prostaglandin e synthase; PDBTitle: electron crystallographic structure of human microsomal2 prostaglandin e synthase 1 6 c3kcqA_ 6.3 20 PDB header:transferase Chain: A: PDB Molecule:phosphoribosylglycinamide formyltransferase; PDBTitle: crystal structure of phosphoribosylglycinamide formyltransferase from2 anaplasma phagocytophilum 7 c1i25A_ 5.9 38 PDB header:toxin Chain: A: PDB Molecule:huwentoxin-ii; PDBTitle: three dimensional solution structure of huwentoxin-ii by 2d2 1h-nmr 8 d1i25a_ 5.9 38 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:omega toxin-like Family:Spider toxins 9 d1xioa_ 5.8 8 Fold:Family A G protein-coupled receptor-like Superfamily:Family A G protein-coupled receptor-like Family:Bacteriorhodopsin-like 10 c1xioA_ 5.8 8 PDB header:signaling protein Chain: A: PDB Molecule:anabaena sensory rhodopsin; PDBTitle: anabaena sensory rhodopsin 11 d4croa_ 5.5 15 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:Phage repressors 12 c2rm9A_ 5.4 22 PDB header:neuropeptide Chain: A: PDB Molecule:astressin2b; PDBTitle: astressin2b

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0