Secondary structure and disorder prediction

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Sequence		M	P	T	K	R	F	D	K	K	H	W	K	M	V	V	V	L	L	A	I	C	G	A	M	L	L	L	R	W	A	A	M	I	W	G
Secondary structure
SS confidence
Disorder		?	?	?			?	?																											?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3qbr chain A Region: 6 - 24 Aligned: 19 Modelled: 19 Confidence: 26.9% Identity: 26% PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja Phyre2 PDB 2o2f chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 15.2% Identity: 28% PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand Phyre2 PDB 1g5m chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 13.7% Identity: 28% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2yv6 chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 13.0% Identity: 28% PDB header:apoptosis Chain: A: PDB Molecule:bcl-2 homologous antagonist/killer; PDBTitle: crystal structure of human bcl-2 family protein bak Phyre2 PDB 1pq1 chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 12.9% Identity: 28% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1ysg chain A domain 1 Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 12.2% Identity: 28% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1zy3 chain A domain 1 Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 11.6% Identity: 17% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2pon chain B domain 1 Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 11.5% Identity: 28% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2xa0 chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 11.3% Identity: 28% PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: crystal structure of bcl-2 in complex with a bax bh32 peptide Phyre2 PDB 2a5y chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 10.5% Identity: 11% PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator ced-9; PDBTitle: structure of a ced-4/ced-9 complex Phyre2 PDB 1o0l chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 9.6% Identity: 17% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1bxl chain A Region: 7 - 24 Aligned: 18 Modelled: 18 Confidence: 8.6% Identity: 28% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1ohu chain A Region: 6 - 24 Aligned: 19 Modelled: 19 Confidence: 7.1% Identity: 11% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 3pk1 chain A Region: 10 - 24 Aligned: 15 Modelled: 15 Confidence: 6.8% Identity: 20% PDB header:apoptosis/apoptosis regulator Chain: A: PDB Molecule:induced myeloid leukemia cell differentiation protein mcl- PDBTitle: crystal structure of mcl-1 in complex with the baxbh3 domain Phyre2 PDB 2knc chain A Region: 15 - 27 Aligned: 13 Modelled: 13 Confidence: 6.2% Identity: 46% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 1 c3qbrA_ 2 c2o2fA_ 3 d1g5ma_ 4 c2yv6A_ 5 d1pq1a_ 6 d1ysga1 7 d1zy3a1 8 d2ponb1 9 c2xa0A_ 10 c2a5yA_ 11 d1o0la_ 12 d1bxla_ 13 d1ohua_ 14 c3pk1A_ 15 c2kncA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3qbrA_ 26.9 26 PDB header:apoptosis Chain: A: PDB Molecule:sjchgc06286 protein; PDBTitle: bakbh3 in complex with sja 2 c2o2fA_ 15.2 28 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand 3 d1g5ma_ 13.7 28 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 4 c2yv6A_ 13.0 28 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2 homologous antagonist/killer; PDBTitle: crystal structure of human bcl-2 family protein bak 5 d1pq1a_ 12.9 28 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 6 d1ysga1 12.2 28 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 7 d1zy3a1 11.6 17 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 8 d2ponb1 11.5 28 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 9 c2xa0A_ 11.3 28 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: crystal structure of bcl-2 in complex with a bax bh32 peptide 10 c2a5yA_ 10.5 11 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator ced-9; PDBTitle: structure of a ced-4/ced-9 complex 11 d1o0la_ 9.6 17 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 12 d1bxla_ 8.6 28 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 13 d1ohua_ 7.1 11 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 14 c3pk1A_ 6.8 20 PDB header:apoptosis/apoptosis regulator Chain: A: PDB Molecule:induced myeloid leukemia cell differentiation protein mcl- PDBTitle: crystal structure of mcl-1 in complex with the baxbh3 domain 15 c2kncA_ 6.2 46 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0