Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	I	L	K	V	I	G	L	L	M	E	Y	P	D	E	L	L	W	E	C	K	E	D	A	L	A	L	I	R	R	D	A	P	M	L	T	D	F	T	H	N	L	L	N	A	P	L	L	D	K	Q	A	E	W	C	E	V	F	D
Secondary structure
SS confidence
Disorder		?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	G	R	T	T	S	L	L	L	F	E	H	V	H	A	E	S	R	D	R	G	Q	A	M	V	D	L	L	A	E	Y	E	K	V	G	L	Q	L	D	C	R	E	L	P	D	Y	L	P	L	Y	L	E	Y	L	S	V	L	P	D	D
Secondary structure
SS confidence
Disorder																	?	?		?																		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	A	K	E	G	L	L	N	V	A	P	I	L	A	L	L	G	G	R	L	K	Q	R	E	A	P	W	Y	A	L	F	D	A	L	L	Q	L	A	G	S	S	L	S	S	D	S	V	T	K	Q	V	N	S	E	E	R	D	D	T	R
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.
Sequence		Q	A	L	D	A	V	W	E	E	E	Q	V	K	F	I	E	D	N	A	T	A	C	D	S	S	P	L	N	Q	Y	Q	R	R	F	S	Q	D	V	A	P	Q	Y	V	D	I	S	A	G	G	G	K
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2o9x chain A domain 1 Region: 2 - 157 Aligned: 146 Modelled: 156 Confidence: 100.0% Identity: 22% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2o9x chain A Region: 2 - 157 Aligned: 146 Modelled: 156 Confidence: 99.9% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus Phyre2 PDB 1n1c chain A Region: 2 - 156 Aligned: 151 Modelled: 155 Confidence: 99.8% Identity: 19% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 1s9u chain A Region: 3 - 154 Aligned: 148 Modelled: 152 Confidence: 99.8% Identity: 18% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2idg chain A domain 1 Region: 87 - 139 Aligned: 52 Modelled: 52 Confidence: 98.5% Identity: 17% Fold: TorD-like Superfamily: TorD-like Family: TorD-like Phyre2 PDB 2di4 chain B Region: 120 - 163 Aligned: 44 Modelled: 44 Confidence: 16.1% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:cell division protein ftsh homolog; PDBTitle: crystal structure of the ftsh protease domain Phyre2 PDB 1lva chain A domain 3 Region: 77 - 100 Aligned: 24 Modelled: 24 Confidence: 13.1% Identity: 21% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: C-terminal fragment of elongation factor SelB Phyre2 PDB 2ce7 chain A domain 1 Region: 72 - 156 Aligned: 85 Modelled: 85 Confidence: 8.9% Identity: 14% Fold: FtsH protease domain-like Superfamily: FtsH protease domain-like Family: FtsH protease domain-like Phyre2 PDB 1ghe chain A Region: 88 - 106 Aligned: 18 Modelled: 19 Confidence: 8.8% Identity: 33% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: N-acetyl transferase, NAT Phyre2 PDB 2g3a chain A domain 1 Region: 88 - 106 Aligned: 18 Modelled: 19 Confidence: 8.7% Identity: 28% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: N-acetyl transferase, NAT Phyre2 PDB 1yx0 chain A domain 1 Region: 88 - 106 Aligned: 18 Modelled: 19 Confidence: 7.8% Identity: 39% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: N-acetyl transferase, NAT Phyre2 PDB 3iwf chain A Region: 4 - 57 Aligned: 54 Modelled: 54 Confidence: 7.4% Identity: 6% PDB header:transcription regulator Chain: A: PDB Molecule:transcription regulator rpir family; PDBTitle: the crystal structure of the n-terminal domain of a rpir2 transcriptional regulator from staphylococcus epidermidis to 1.4a Phyre2 PDB 2d6f chain C domain 2 Region: 77 - 106 Aligned: 29 Modelled: 30 Confidence: 7.0% Identity: 31% Fold: DCoH-like Superfamily: GAD domain-like Family: GAD domain Phyre2 PDB 2r7h chain A Region: 88 - 106 Aligned: 18 Modelled: 19 Confidence: 6.8% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:putative d-alanine n-acetyltransferase of gnat family; PDBTitle: crystal structure of a putative acetyltransferase of the gnat family2 (dde_3044) from desulfovibrio desulfuricans subsp. at 1.85 a3 resolution Phyre2 PDB 2zw3 chain B Region: 184 - 202 Aligned: 19 Modelled: 19 Confidence: 6.5% Identity: 32% PDB header:cell adhesion Chain: B: PDB Molecule:gap junction beta-2 protein; PDBTitle: structure of the connexin-26 gap junction channel at 3.52 angstrom resolution Phyre2 PDB 2cnt chain D Region: 88 - 106 Aligned: 18 Modelled: 19 Confidence: 6.4% Identity: 28% PDB header:transferase Chain: D: PDB Molecule:modification of 30s ribosomal subunit protein s18; PDBTitle: rimi - ribosomal s18 n-alpha-protein acetyltransferase in2 complex with coenzymea. Phyre2 PDB 2psw chain A Region: 88 - 106 Aligned: 18 Modelled: 19 Confidence: 5.9% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:n-acetyltransferase 13; PDBTitle: human mak3 homolog in complex with coa Phyre2 PDB 1puz chain A Region: 4 - 42 Aligned: 39 Modelled: 39 Confidence: 5.7% Identity: 10% Fold: YgfY-like Superfamily: YgfY-like Family: YgfY-like Phyre2 PDB 2ree chain B Region: 88 - 108 Aligned: 20 Modelled: 21 Confidence: 5.4% Identity: 30% PDB header:transferase, lyase Chain: B: PDB Molecule:cura; PDBTitle: crystal structure of the loading gnatl domain of cura from lyngbya2 majuscula Phyre2 PDB 1ev0 chain A Region: 104 - 110 Aligned: 7 Modelled: 7 Confidence: 5.4% Identity: 57% Fold: Cell division protein MinE topological specificity domain Superfamily: Cell division protein MinE topological specificity domain Family: Cell division protein MinE topological specificity domain Phyre2 1 d2o9xa1 2 c2o9xA_ 3 d1n1ca_ 4 d1s9ua_ 5 d2idga1 6 c2di4B_ 7 d1lvaa3 8 d2ce7a1 9 d1ghea_ 10 d2g3aa1 11 d1yx0a1 12 c3iwfA_ 13 d2d6fc2 14 c2r7hA_ 15 c2zw3B_ 16 c2cntD_ 17 c2pswA_ 18 d1puza_ 19 c2reeB_ 20 d1ev0a_ 21 22

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2o9xa1 100.0 22 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 2 c2o9xA_ 99.9 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:reductase, assembly protein; PDBTitle: crystal structure of a putative redox enzyme maturation protein from2 archaeoglobus fulgidus 3 d1n1ca_ 99.8 19 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 4 d1s9ua_ 99.8 18 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 5 d2idga1 98.5 17 Fold:TorD-like Superfamily:TorD-like Family:TorD-like 6 c2di4B_ 16.1 20 PDB header:hydrolase Chain: B: PDB Molecule:cell division protein ftsh homolog; PDBTitle: crystal structure of the ftsh protease domain 7 d1lvaa3 13.1 21 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:C-terminal fragment of elongation factor SelB 8 d2ce7a1 8.9 14 Fold:FtsH protease domain-like Superfamily:FtsH protease domain-like Family:FtsH protease domain-like 9 d1ghea_ 8.8 33 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 10 d2g3aa1 8.7 28 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 11 d1yx0a1 7.8 39 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 12 c3iwfA_ 7.4 6 PDB header:transcription regulator Chain: A: PDB Molecule:transcription regulator rpir family; PDBTitle: the crystal structure of the n-terminal domain of a rpir2 transcriptional regulator from staphylococcus epidermidis to 1.4a 13 d2d6fc2 7.0 31 Fold:DCoH-like Superfamily:GAD domain-like Family:GAD domain 14 c2r7hA_ 6.8 22 PDB header:transferase Chain: A: PDB Molecule:putative d-alanine n-acetyltransferase of gnat family; PDBTitle: crystal structure of a putative acetyltransferase of the gnat family2 (dde_3044) from desulfovibrio desulfuricans subsp. at 1.85 a3 resolution 15 c2zw3B_ 6.5 32 PDB header:cell adhesion Chain: B: PDB Molecule:gap junction beta-2 protein; PDBTitle: structure of the connexin-26 gap junction channel at 3.52 angstrom resolution 16 c2cntD_ 6.4 28 PDB header:transferase Chain: D: PDB Molecule:modification of 30s ribosomal subunit protein s18; PDBTitle: rimi - ribosomal s18 n-alpha-protein acetyltransferase in2 complex with coenzymea. 17 c2pswA_ 5.9 22 PDB header:transferase Chain: A: PDB Molecule:n-acetyltransferase 13; PDBTitle: human mak3 homolog in complex with coa 18 d1puza_ 5.7 10 Fold:YgfY-like Superfamily:YgfY-like Family:YgfY-like 19 c2reeB_ 5.4 30 PDB header:transferase, lyase Chain: B: PDB Molecule:cura; PDBTitle: crystal structure of the loading gnatl domain of cura from lyngbya2 majuscula 20 d1ev0a_ 5.4 57 Fold:Cell division protein MinE topological specificity domain Superfamily:Cell division protein MinE topological specificity domain Family:Cell division protein MinE topological specificity domain 21 d1q8ha_ not modelled 5.3 50 Fold:GLA-domain Superfamily:GLA-domain Family:GLA-domain 22 c1q8hA_ not modelled 5.3 50 PDB header:metal binding protein Chain: A: PDB Molecule:osteocalcin; PDBTitle: crystal structure of porcine osteocalcin

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0