Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	I	Y	C	C	L	N	T	V	G	F	F	M	D	G	C	G	V	I	P	P	D	S	K	E	I	T	A	E	H	W	Q	S	L	L	K	S	Q	A	E	G	G	V	I	D	F	S	V	F	P	P	S	I	K	E	V	I	R	T
Secondary structure
SS confidence
Disorder		?	?																																							?	?		?													?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	D	D	E	V	A	D	A	N	F	Q	K	Q	M	L	I	S	D	A	T	D	F	I	N	S	R	Q	W	Q	G	K	A	A	L	G	R	L	K	E	D	E	L	K	Q	Y	N	L	W	L	D	Y	L	E	A	L	E	L	V	D	T
Secondary structure
SS confidence
Disorder																												?					?				?	?																				?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.
Sequence		S	S	A	P	D	I	E	W	P	T	P	P	A	V	Q	A	R
Secondary structure
SS confidence
Disorder			?									?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2kz6 chain A Region: 61 - 132 Aligned: 61 Modelled: 72 Confidence: 98.3% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2 Phyre2 PDB 3o0r chain C Region: 97 - 129 Aligned: 25 Modelled: 28 Confidence: 41.9% Identity: 28% PDB header:immune system/oxidoreductase Chain: C: PDB Molecule:nitric oxide reductase subunit c; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment Phyre2 PDB 1fcq chain A Region: 1 - 71 Aligned: 68 Modelled: 71 Confidence: 17.6% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Bee venom hyaluronidase Phyre2 PDB 1d4b chain A Region: 22 - 51 Aligned: 30 Modelled: 30 Confidence: 14.1% Identity: 23% Fold: beta-Grasp (ubiquitin-like) Superfamily: CAD & PB1 domains Family: CAD domain Phyre2 PDB 2atm chain A Region: 1 - 54 Aligned: 51 Modelled: 54 Confidence: 10.9% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure of the recombinant allergen ves v 2 Phyre2 PDB 1bgv chain A domain 2 Region: 97 - 121 Aligned: 25 Modelled: 25 Confidence: 8.9% Identity: 8% Fold: Aminoacid dehydrogenase-like, N-terminal domain Superfamily: Aminoacid dehydrogenase-like, N-terminal domain Family: Aminoacid dehydrogenases Phyre2 PDB 1twf chain C domain 1 Region: 5 - 25 Aligned: 21 Modelled: 21 Confidence: 8.7% Identity: 24% Fold: DCoH-like Superfamily: RBP11-like subunits of RNA polymerase Family: RNA polymerase alpha subunit dimerisation domain Phyre2 PDB 2q22 chain A domain 1 Region: 69 - 130 Aligned: 58 Modelled: 62 Confidence: 8.3% Identity: 16% Fold: Ava3019-like Superfamily: Ava3019-like Family: Ava3019-like Phyre2 PDB 1zak chain A domain 2 Region: 127 - 137 Aligned: 11 Modelled: 11 Confidence: 7.7% Identity: 18% Fold: Rubredoxin-like Superfamily: Microbial and mitochondrial ADK, insert "zinc finger" domain Family: Microbial and mitochondrial ADK, insert "zinc finger" domain Phyre2 PDB 2ahm chain G Region: 113 - 129 Aligned: 17 Modelled: 17 Confidence: 6.8% Identity: 24% PDB header:viral protein, replication Chain: G: PDB Molecule:replicase polyprotein 1ab, heavy chain; PDBTitle: crystal structure of sars-cov super complex of non-structural2 proteins: the hexadecamer Phyre2 PDB 1ibx chain B Region: 22 - 39 Aligned: 18 Modelled: 18 Confidence: 6.3% Identity: 17% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:chimera of igg binding protein g and dna PDBTitle: nmr structure of dff40 and dff45 n-terminal domain complex Phyre2 PDB 1ibx chain B Region: 22 - 39 Aligned: 18 Modelled: 18 Confidence: 6.3% Identity: 17% Fold: beta-Grasp (ubiquitin-like) Superfamily: CAD & PB1 domains Family: CAD domain Phyre2 PDB 1x4t chain A domain 1 Region: 49 - 107 Aligned: 53 Modelled: 59 Confidence: 6.0% Identity: 19% Fold: Long alpha-hairpin Superfamily: ISY1 domain-like Family: ISY1 N-terminal domain-like Phyre2 PDB 2eel chain A Region: 22 - 52 Aligned: 31 Modelled: 31 Confidence: 5.5% Identity: 13% PDB header:apoptosis Chain: A: PDB Molecule:cell death activator cide-a; PDBTitle: solution structure of the cide-n domain of human cell death2 activator cide-a Phyre2 1 c2kz6A_ 2 c3o0rC_ 3 d1fcqa_ 4 d1d4ba_ 5 c2atmA_ 6 d1bgva2 7 d1twfc1 8 d2q22a1 9 d1zaka2 10 c2ahmG_ 11 c1ibxB_ 12 d1ibxb_ 13 d1x4ta1 14 c2eelA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2kz6A_ 98.3 20 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2 2 c3o0rC_ 41.9 28 PDB header:immune system/oxidoreductase Chain: C: PDB Molecule:nitric oxide reductase subunit c; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment 3 d1fcqa_ 17.6 22 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Bee venom hyaluronidase 4 d1d4ba_ 14.1 23 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:CAD domain 5 c2atmA_ 10.9 27 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure of the recombinant allergen ves v 2 6 d1bgva2 8.9 8 Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Aminoacid dehydrogenases 7 d1twfc1 8.7 24 Fold:DCoH-like Superfamily:RBP11-like subunits of RNA polymerase Family:RNA polymerase alpha subunit dimerisation domain 8 d2q22a1 8.3 16 Fold:Ava3019-like Superfamily:Ava3019-like Family:Ava3019-like 9 d1zaka2 7.7 18 Fold:Rubredoxin-like Superfamily:Microbial and mitochondrial ADK, insert "zinc finger" domain Family:Microbial and mitochondrial ADK, insert "zinc finger" domain 10 c2ahmG_ 6.8 24 PDB header:viral protein, replication Chain: G: PDB Molecule:replicase polyprotein 1ab, heavy chain; PDBTitle: crystal structure of sars-cov super complex of non-structural2 proteins: the hexadecamer 11 c1ibxB_ 6.3 17 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:chimera of igg binding protein g and dna PDBTitle: nmr structure of dff40 and dff45 n-terminal domain complex 12 d1ibxb_ 6.3 17 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:CAD domain 13 d1x4ta1 6.0 19 Fold:Long alpha-hairpin Superfamily:ISY1 domain-like Family:ISY1 N-terminal domain-like 14 c2eelA_ 5.5 13 PDB header:apoptosis Chain: A: PDB Molecule:cell death activator cide-a; PDBTitle: solution structure of the cide-n domain of human cell death2 activator cide-a

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0