Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	P	L	N	D	L	S	L	K	T	Q	P	V	Q	L	N	K	V	T	S	N	T	E	S	T	I	K	Q	H	E	L	V	S	D	D	A	I	I	N	E	L	S	S	E	L	V	S	C	L	G	N	G	K	F	T	P	I	S	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?		?		?		?	?	?	?	?		?	?	?	?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.
Sequence		D	S	K	L	F	N	M	L	S	E	F	K	L	L	H	S	E	Y	F	E	W	G	D	Y	S	L	W	F	Q	D	F	S	I	Y	N	K	I	G	F	I	M	I	E	K	I	R	E	L	V	T	H	P	F	G	I	N
Secondary structure
SS confidence
Disorder																																																				?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2k5c chain A Region: 53 - 72 Aligned: 20 Modelled: 20 Confidence: 12.9% Identity: 45% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein pf0385; PDBTitle: nmr structure for pf0385 Phyre2 PDB 3otb chain B Region: 34 - 88 Aligned: 55 Modelled: 55 Confidence: 10.7% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:trna(his) guanylyltransferase; PDBTitle: crystal structure of human trnahis guanylyltransferase (thg1) - dgtp2 complex Phyre2 PDB 1gm5 chain A domain 1 Region: 96 - 106 Aligned: 11 Modelled: 11 Confidence: 9.1% Identity: 45% Fold: Four-helical up-and-down bundle Superfamily: RecG, N-terminal domain Family: RecG, N-terminal domain Phyre2 PDB 1oey chain J Region: 76 - 95 Aligned: 20 Modelled: 20 Confidence: 7.6% Identity: 20% Fold: beta-Grasp (ubiquitin-like) Superfamily: CAD & PB1 domains Family: PB1 domain Phyre2 PDB 1kdx chain B Region: 38 - 45 Aligned: 8 Modelled: 8 Confidence: 7.3% Identity: 63% PDB header:transcription regulation complex Chain: B: PDB Molecule:creb; PDBTitle: kix domain of mouse cbp (creb binding protein) in complex2 with phosphorylated kinase inducible domain (pkid) of rat3 creb (cyclic amp response element binding protein), nmr 174 structures Phyre2 PDB 3euk chain L Region: 35 - 94 Aligned: 59 Modelled: 60 Confidence: 7.3% Identity: 20% PDB header:cell cycle Chain: L: PDB Molecule:chromosome partition protein muke; PDBTitle: crystal structure of muke-mukf(residues 292-443)-mukb(head2 domain)-atpgammas complex, asymmetric dimer Phyre2 PDB 3ejh chain B Region: 49 - 62 Aligned: 14 Modelled: 14 Confidence: 7.2% Identity: 29% PDB header:cell adhesion Chain: B: PDB Molecule:fibronectin; PDBTitle: crystal structure of the fibronectin 8-9fni domain pair in complex2 with a type-i collagen peptide Phyre2 PDB 1x4q chain A Region: 42 - 72 Aligned: 31 Modelled: 31 Confidence: 7.2% Identity: 32% PDB header:rna binding protein Chain: A: PDB Molecule:u4/u6 small nuclear ribonucleoprotein prp3; PDBTitle: solution structure of pwi domain in u4/u6 small nuclear2 ribonucleoprotein prp3(hprp3) Phyre2 PDB 3chm chain A Region: 59 - 108 Aligned: 42 Modelled: 50 Confidence: 6.5% Identity: 24% PDB header:plant protein Chain: A: PDB Molecule:cop9 signalosome complex subunit 7; PDBTitle: crystal structure of pci domain from a. thaliana cop9 signalosome2 subunit 7 (csn7) Phyre2 PDB 2kmc chain A Region: 80 - 90 Aligned: 11 Modelled: 11 Confidence: 6.3% Identity: 45% PDB header:cell adhesion Chain: A: PDB Molecule:fermitin family homolog 1; PDBTitle: solution structure of the n-terminal domain of kindlin-1 Phyre2 PDB 3lr6 chain A Region: 36 - 70 Aligned: 35 Modelled: 35 Confidence: 5.8% Identity: 20% PDB header:structural protein Chain: A: PDB Molecule:major ampullate spidroin 1; PDBTitle: self-assembly of spider silk proteins is controlled by a ph-sensitive2 relay Phyre2 PDB 3n7m chain A Region: 82 - 96 Aligned: 15 Modelled: 15 Confidence: 5.7% Identity: 33% PDB header:toxin Chain: A: PDB Molecule:neurotoxin; PDBTitle: crystal structure of w1252a mutant of hcr d/c vpi 5995 Phyre2 1 c2k5cA_ 2 c3otbB_ 3 d1gm5a1 4 d1oeyj_ 5 c1kdxB_ 6 c3eukL_ 7 c3ejhB_ 8 c1x4qA_ 9 c3chmA_ 10 c2kmcA_ 11 c3lr6A_ 12 c3n7mA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2k5cA_ 12.9 45 PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein pf0385; PDBTitle: nmr structure for pf0385 2 c3otbB_ 10.7 24 PDB header:transferase Chain: B: PDB Molecule:trna(his) guanylyltransferase; PDBTitle: crystal structure of human trnahis guanylyltransferase (thg1) - dgtp2 complex 3 d1gm5a1 9.1 45 Fold:Four-helical up-and-down bundle Superfamily:RecG, N-terminal domain Family:RecG, N-terminal domain 4 d1oeyj_ 7.6 20 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:PB1 domain 5 c1kdxB_ 7.3 63 PDB header:transcription regulation complex Chain: B: PDB Molecule:creb; PDBTitle: kix domain of mouse cbp (creb binding protein) in complex2 with phosphorylated kinase inducible domain (pkid) of rat3 creb (cyclic amp response element binding protein), nmr 174 structures 6 c3eukL_ 7.3 20 PDB header:cell cycle Chain: L: PDB Molecule:chromosome partition protein muke; PDBTitle: crystal structure of muke-mukf(residues 292-443)-mukb(head2 domain)-atpgammas complex, asymmetric dimer 7 c3ejhB_ 7.2 29 PDB header:cell adhesion Chain: B: PDB Molecule:fibronectin; PDBTitle: crystal structure of the fibronectin 8-9fni domain pair in complex2 with a type-i collagen peptide 8 c1x4qA_ 7.2 32 PDB header:rna binding protein Chain: A: PDB Molecule:u4/u6 small nuclear ribonucleoprotein prp3; PDBTitle: solution structure of pwi domain in u4/u6 small nuclear2 ribonucleoprotein prp3(hprp3) 9 c3chmA_ 6.5 24 PDB header:plant protein Chain: A: PDB Molecule:cop9 signalosome complex subunit 7; PDBTitle: crystal structure of pci domain from a. thaliana cop9 signalosome2 subunit 7 (csn7) 10 c2kmcA_ 6.3 45 PDB header:cell adhesion Chain: A: PDB Molecule:fermitin family homolog 1; PDBTitle: solution structure of the n-terminal domain of kindlin-1 11 c3lr6A_ 5.8 20 PDB header:structural protein Chain: A: PDB Molecule:major ampullate spidroin 1; PDBTitle: self-assembly of spider silk proteins is controlled by a ph-sensitive2 relay 12 c3n7mA_ 5.7 33 PDB header:toxin Chain: A: PDB Molecule:neurotoxin; PDBTitle: crystal structure of w1252a mutant of hcr d/c vpi 5995

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0