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Job DescriptionP43672
Confidence100.00%DateWed Jan 25 15:20:54 GMT 2012
Rank5Aligned Residues499
% Identity29%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   4.....10... ......20.........30.........40.........50.........60....... ..
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Query Sequence  ISMHGAWLSF. . . SDAPLLDNAELHIEDNERVCLVGRNGAGKSTLMKILNREQGLDDGRIIYEQDLI. . . . . . . . . . . VA
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Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIG
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460.......
 
   70.........80.........90.........100.........110.........120.........130.........140.........
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Query Sequence  RLQQDPPRNVEGSVYDFVAEGIEEQAEYLKRYHDISRLVMNDPSEKNLNELAKVQEQLDHHNLWQLENRINEVLAQLGLD
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Template Sequence  VVSQEPVLFAT. TIAENIRYGREDVTM. . . . . . . . . . . . . . . . . . . . . . . . DEIEKAVKEANAYD. . . FIMKLPHQFDTL
Template Known Secondary structure  SS



SS.

SS

........................TT
TT...STTGGG

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   468.470........ .480.........490... ......500....... ..510.........
 
   150.........160.........170.........180.........190.........200.. .......210.........220.......
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Query Sequence  PNVALSSLSGGWLRKAALGRALVSNPRVLLLDEPTNHLDIETIDWLEGFLKTF. . NGTIIFISHDRSFIRNMATRIVDLD
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Template Sequence  VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVR. NADVIAGFD
Template Known Secondary structure 
SSSS
SS


SBTT
SS
TTSS
S
T.T
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   520.........530.........540.........550.........560.........570.........580......... 590........
 
   228.230.........240.........250.........260.........270......
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Query Sequence  RGKLVTYPGNYDQYLLEKEEALRVEELQNAEFDRKLAQEEVWIRQGIKA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  GGVIVE. QGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGV
Template Known Secondary structure  SS



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   599600.... .....610.........620.........630.........640.........650.........660.........670.......
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                               
                   
   
   
               
 
  
 
Template Sequence  FTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRL
Template Known Secondary structure  SS
STT

S
S

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   735....740.........750.........760.........770.........780.........790.........800.........810....
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  ANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIAT
Template Known Secondary structure  SS
STT
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   815....820.........830.........840.........850.........860.........870.........880.........890....
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  EAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVF
Template Known Secondary structure  TT
TTTTT
SS

TTTT
S
STT
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   895....900.........910.........920.........930.........940.........950.........960.........970....
 
   277..280.........290.........300.........310.........320......... 330........
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Query Sequence  . . . . . . . . . . . . . . . RRTRNEGRVRALKAMRRERGERREVMGTAKMQVEEASRSGKIVFEMEDVCYQV. . . NGKQLVKDF
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Template Sequence  SAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEG. . NVQFSGVVFNYPTRPSIPVLQGL
Template Known Secondary structure  TSSSS
SS




SS
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TTT


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SS
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   975....980.........990.........1000.........1010.........1020......... 1030.........1040.........1050..
 
   339340.........350.........360.........370........ .380... ......390.........400.......
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Query Sequence  SAQVLRGDKIALIGPNGCGKTTLLKLMLGQLQADSGRIHV. GTKLE. . . . . . . . . . VAYFDQHRAELDPDKTVMDNLAEG
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Template Sequence  SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFD. . CSIAENIAYG
Template Known Secondary structure 

SSS
SSSTTTTSS

SSSSS
BTSS
TTS
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S..SBT

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   1053......1060.........1070.........1080.........1090.........1100.........1110.........1120 .........1130
 
   408.410.........420.........430 .........440 .........450.........460.........470.......
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Query Sequence  KQEVMVNGKPRHVLGYLQDFLFH. . . . . . PKRAMTPVRA. . . . LSGGERNRLLLARLFLKPSNLLILDEPTNDLDVETLE
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Template Sequence  DNSRVVSYEE. . IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK
Template Known Secondary structure 
SS



..T
SSTTTGGG
B
STTS
SS


SSS
SSS

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   1131........1140 .........1150.........1160.........1170.........1180.........1190.........1200........
 
   478.480...... ...490.........500.........510.........520.........530.........540.
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Query Sequence  LLEELIDSY. . QGTVLLVSHDRQFVDNTVTECWIFEGGGKIGRYVGGYHDARGQQEQYVALKQPAV
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Template Sequence  VVQEALDKAREGRTCIVIAHRLSTIQN. ADLIVVIQ. NGKVKE. HGTHQQLLAQKGIYFSMVSVQA
Template Known Secondary structure  SSSS

S
TTGGGS.
S.TB.
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   12091210.........1220.........1230..... ....1240... ...... 1250.........1260.........1270.
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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