|   |
2 | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | |
|
. | . | . | . | . | 40 | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . |
|  |  |  |  |  |
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
T | D | K | I | A | V | L | L | G | G | T | S | A | E | R | E | V | S | L | N | S | G | A | A | V | L | A | G | L | R | E | G | G | . |
. |
I | D | A | Y | P | V | D | P | K | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
E | V | D | V | T | Q | L | K | S | M | G | F | Q | K | V | F | I | A | L |
Query Conservation |   |
  |   |
|
|   |
|   |   |
|
|   |   |   |
|   |   |
|   |
|   |
|   |   |   |
|   |   |
|
|   |   |   |
| . | . |   |   |
|   |   |
|
|   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
Template Conservation |   |
  |
|
|
|
|
|
|
|   |
|   |   | . | . | . | . | . | . | . | . | . |   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |
|   |
|   |   | . | . |
Template Sequence |   |
S | M | N | V | L | V | I | G | S | G | G | R | . |
. |
. |
. |
. |
. |
. |
. |
. |
E | H | S | M | L | H | H | I | R | K | S | T | L | L | N | K | L | F | I | A | P | G | R | E | G | M | S | G | L | A | D | I | I | D | I | D | I | N | S | T | I | E | V | I | Q | V | C | K | K | E | K | I | E | L | V | V | I | . |
. |
Template Known Secondary structure |   |
|  |  |  |  |  |  |  |
| S |  |  | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  | T | T |
| T | T |  |  |  |  |  |  |  |  |
|
| G | G | G | T | T | T | S |  |  |
|
|
|
| T | T |
|  |  |  |  |  |  |  |  |  |  | T | T |
|
|  |  |  |  | . | . |
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |
|
|
|  |  | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
0 | . | . | . | . | . | . | . | . | . | 10 | . | |
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | |
|
  |
  |   |
63 | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . |
Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |
|
|
|  |  |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |
|  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
H | G | R | G | G | E | D | G | T | L | Q | G | M | L | E | L | M | G | L | P | Y | T | G | S | G | V | M | A | S | A | L | S | M | D | K | L | R | S | K | L | L | W | Q | G | A | G | L | P | V | A | P | W | V | A | L | T | R | A | E | F | E | K | G | L | S | D | K | Q | L | A | E | I | S | A | L | G | L | P | V | I |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |   |   |   |
|   |   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |
|   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |
|   |   |
|   |   |   |
|
|
|   |
|   |   |   |   |   |   |   | . | . | . | . | . | . | . |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
|
|
Template Sequence |   |
G | P | E | T | P | L | M | N | G | L | S | D | A | L | T | E | E | G | I | L | V | F | G | P | S | K | A | A | A | R | L | E | S | S | K | G | F | T | K | E | L | C | M | R | Y | G | I | P | T | A | K | Y | G | Y | F | V | D | . |
. |
. |
. |
. |
. |
. |
T | N | S | A | Y | K | F | I | D | K | H | K | L | P | L | V |
Template Known Secondary structure |   |
| S |  |  |  |  |  | T | T |  |  |  |  |  |  |  | T | T |
|  |  |  | S |
|
|  |  |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |  | T |
|
| B |
|
|  |  |  |  | S | S | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  | S |
| S | S |  |  |
Template Predicted Secondary structure |   |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |
|
| . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
69 | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | |
|
|
|
|
|
|
. | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . |
  |
  |   |
143 | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | |
|
|
|
|
|
. | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | |
|
Predicted Secondary structure |   |
 |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
| . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |
|
|
|
| . | . |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
Query Sequence |   |
V | K | P | S | R | E | G | S | S | V | G | M | S | K | V | V | A | E | N | A | L | Q | D | A | L | R | L | A | F | Q | H | . |
. |
. |
. |
. |
. |
D | E | E | V | L | I | E | K | W | L | S | G | P | E | F | T | V | A | I | L | G | E | E | I | L | P | S | I | R | I | Q | P | S | G | T | F | Y | D | Y | E | A | . |
. |
Query Conservation |   |
|
|
|   |   |
|   |   |
|   |
|   |   |   |   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
Template Conservation |   |
|
|
|   |   |
|   |
|   |   |
|
|   |   |
|   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |
|   |
|   |
|   |
|
|   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
V | K | A | D | G | L | A | Q | G | K | G | T | V | I | C | H | T | H | E | E | A | Y | N | A | V | D | A | M | L | V | H | H | K | F | G | E | A | G | C | A | I | I | I | E | E | F | L | E | G | K | E | I | S | F | F | T | L | V | D | G | S | N | P | V | I | L | G | V | A | Q | D | Y | K | T | I | G | D | N | N | K |
Template Known Secondary structure |   |
 |  |  | S | S |
|
| T | T | T | S |  |  |  |  | S | S |  |  |  |  |  |  |  |  |  |  |  |  | T | S |
| T | T | G | G | G | G | S | S |  |  |  |  |  |
|
|
| S |  |  |  |  |  |  |  |  |  |  | S | S |
|  |  |  |  |  |  |  |  |  |
|
|  |  |  | G | G | G |  |
Template Predicted Secondary structure |   |
 |  |
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
142 | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . |
  |
  |   |
215 | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | |
|
. | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
| . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| . | . |
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
K | Y | L | S | D | E | T | Q | Y | F | C | P | A | G | L | . |
. |
. |
. |
. |
E | A | S | Q | E | A | N | L | Q | A | L | V | L | K | A | W | T | T | L | G | C | . |
. |
K | G | W | G | R | I | D | V | M | L | D | S | D | G | Q | F | Y | L | L | E | A | N | T | S | P | G | M | T | S | H | S | L | V | P | M | A | A |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |
|   |   |   | . | . | . | . | . |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
|   | . | . |   |
|   |   |   |
|
|   |   |   |   |   |
|
|   |   |   |
|
|
|
|
|   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |
|
|   |   |   |
|   |   |   |
|
|   |   |
|   |   |   |   | . |   |   |
|
|
|
|
|   |
|   |
| . | . | . |
|   |   |   |   |   |   |   |
Template Sequence |   |
G | P | N | T | G | G | M | G | S | Y | S | K | P | N | I | I | T | Q | E | M | E | H | I | I | I | Q | K | I | I | Y | P | T | I | K | A | M | F | N | M | N | I | Q | F | R | G | L | L | F | A | G | I | I | I | K | K | N | E | . |
P | K | L | L | E | Y | N | V | R | F | G | . |
. |
. |
D | P | E | T | Q | S | I | L |
Template Known Secondary structure |   |
 |  |  |
| S |
| S |  |  |  |  |
| T | T | S | S |
|  |  |  |  |  |  |  |  |  |  | T |  |  |  |  |  |  |  |  |  |  | T | T |
|
|
|  |  |  |  |  |  |  |  |  |  |  | T | T |  | . |  |  |  |  |  |  |  | S | S |
|
| . | . | . | T | T |  |  |  |  |  | G |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
| . |  |  |  |  |  |  |
|
|
|
|
| . | . | . |
|
|  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
222 | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | |
. | 280 | . | . | . | . | . | . | . | . | . | |
|
|
290 | . | . | . | . | . | . | . |
  |
  |   |
288 | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . |
Predicted Secondary structure |   |
 |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
R | Q | A | G | M | S | F | S | Q | L | V | V | R | I | L | E |
Query Conservation |   |
  |   |   |
|   |   |   |   |   |
|
|   |   |
|
|   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
P | R | L | N | S | D | F | L | K | L | L | S | L | T | A | K |
Template Known Secondary structure |   |
G | G | B |
| S |
|  |  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
 |  |  |
|
|
|  |  |  |  |  |  |  |  |  |
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
298 | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . |
  |