Job Description P29018 Confidence 100.00% Date Thu Jan 5 11:45:34 GMT 2012 Rank 4 Aligned Residues 572 % Identity 21% Template c3g5uB_ PDB info PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Resolution 3.80 Å

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		8	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.																				.	.	60	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		E	L	T	R	W	L	K	Q	Q	S	V	I	S	Q	R	W	L	N	I	S	R	L	L	G	F	V	S	G	I	L	I	I	A	Q	A	W	F	M	A	R	I	L	Q	H	M	I	M	E	N	I	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P	R	E	A	L	L	L	P	F	T	L
Query Conservation																																																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																																																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		S	V	L	T	M	F	R	Y	A	G	W	L	D	R	L	Y	M	L	V	G	T	L	A	A	I	I	H	G	V	A	L	P	L	M	M	L	I	F	G	D	M	T	D	S	F	A	S	V	G	N	V	S	K	N	S	T	N	M	S	E	A	D	K	R	A	M	F	A	K	L	E	E	E	M	T	T	Y	A	Y	Y
Template Known Secondary structure		T	T					T																																																	S	S		S
Template Predicted Secondary structure
Template SS confidence
		34	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.
		69	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	V	L	T	F	V	L	R	A	W	V	V	W	L	R	E	R	V	G	Y	H	A	G	Q	H	I	R	F	A	I	R	R	Q	V	L	D	R	L	Q	Q	A	G	P	A	W	I	Q	G	K	P	A	G	S	W	A	T	L	V	L	E	Q	I	D	D	M	H	D	Y	Y	A	R	Y	L	P	Q	M	A	L	A	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	T	G	I	G	A	G	V	L	I	V	A	Y	I	Q	V	S	F	W	C	L	A	A	G	R	Q	I	H	K	I	R	Q	K	F	F	H	A	I	M	N	Q	E	I	G	W	F	D	V	H	D	V	G	E	L	N	T	R	L	T	D	D	V	S	K	I	N	E	G	I	G	D	K	I	G	M	F	F	Q	A	M
Template Known Secondary structure																																											T	T					S	S		S
Template Predicted Secondary structure
Template SS confidence
		114	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.
		149	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	V	P	L	L	I	V	V	A	I	F	P	S	N	W	A	A	A	L	I	L	L	G	T	A	P	L	I	P	L	F	M	A	L	V	G	M	G	A	A	D	A	N	R	R	N	F	L	A	L	A	R	L	S	G	H	F	L	D	R	L	R	G	M	E	T	L	R	I	F	G	R	G	E	A	E	I	E	S	I
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	T	F	F	G	G	F	I	I	G	F	T	R	G	W	K	L	T	L	V	I	L	A	I	S	P	V	L	G	L	S	A	G	I	W	A	K	I	L	S	S	F	T	D	K	E	L	H	A	Y	A	K	A	G	A	V	A	E	E	V	L	A	A	I	R	T	V	I	A	F	G	G	Q	K	K	E	L	E	R	Y
Template Known Secondary structure														T	T	T	T	S																																							T	T	T											T	T					S
Template Predicted Secondary structure
Template SS confidence
		194	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.
		229	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	S	A	S	E	D	F	R	Q	R	T	M	E	V	L	R	L	A	F	L	S	S	G	I	L	E	F	F	T	S	L	S	I	A	L	V	A	V	Y	F	G	F	S	Y	L	G	E	L	D	F	G	H	Y	D	T	G	V	T	L	A	A	G	F	L	A	L	I	L	A	P	E	F	F	Q	P	L	R	D	L	G
Query Conservation
Alig confidence																																														.	.	.	.	.	.	.	.
Template Conservation																																														.	.	.	.	.	.	.	.
Template Sequence		N	N	N	L	E	E	A	K	R	L	G	I	K	K	A	I	T	A	N	I	S	M	G	A	A	F	L	L	I	Y	A	S	Y	A	L	A	F	W	Y	G	T	S	L	V	.	.	.	.	.	.	.	.	I	S	K	E	Y	S	I	G	Q	V	L	T	V	F	F	S	V	L	I	G	A	F	S	V	G	Q	A	S
Template Known Secondary structure														T	T	T																														.	.	.	.	.	.	.	.			S	S	S		S	S
Template Predicted Secondary structure																																														.	.	.	.	.	.	.	.
Template SS confidence
		274	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.									.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.
		309	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.		.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.			.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.
Predicted Secondary structure																									.																																.	.
Query SS confidence																									.																																.	.
Query Sequence		T	F	Y	H	A	K	A	Q	A	V	G	A	A	D	S	L	K	T	F	M	E	T	P	.	L	A	H	P	Q	R	G	E	A	E	L	A	S	T	D	P	V	T	I	E	A	E	E	L	F	I	T	S	P	E	G	.	.	K	T	L	A	G	P	L	N	F	T	L	P	A	G	Q	R	A	V	L	V	G	R	S
Query Conservation																									.																																.	.
Alig confidence																									.																																.	.
Template Conservation
Template Sequence		P	N	I	E	A	F	A	N	A	R	G	A	A	Y	E	V	F	K	I	I	D	N	K	P	S	I	D	S	F	S	K	S	G	H	K	P	D	N	I	Q	G	N	L	E	F	K	N	I	H	F	S	Y	P	S	R	K	E	V	Q	I	L	K	G	L	N	L	K	V	K	S	G	Q	T	V	A	L	V	G	N	S
Template Known Secondary structure																				T	T	S						S	S			S						T	T		S													S	S	T	T	S			S										T	T									S
Template Predicted Secondary structure
Template SS confidence
		346	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.
		386	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.		.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.
Predicted Secondary structure																			.
Query SS confidence																			.
Query Sequence		G	S	G	K	S	S	L	L	N	A	L	S	G	F	L	S	Y	.	Q	G	S	L	R	I	N	G	I	E	L	R	D	L	S	P	E	S	W	R	K	H	L	S	W	V	G	Q	N	P	Q	L	P	A	A	T	L	R	D	N	V	L	L	A	R	P	D	A	S	E	Q	E	L	Q	A	A	L	D	N	A	W	V
Query Conservation																			.
Alig confidence																			.
Template Conservation
Template Sequence		G	C	G	K	S	T	T	V	Q	L	M	Q	R	L	Y	D	P	L	D	G	M	V	S	I	D	G	Q	D	I	R	T	I	N	V	R	Y	L	R	E	I	I	G	V	V	S	Q	E	P	V	L	F	A	T	T	I	A	E	N	I	R	Y	G	R	E	D	V	T	M	D	E	I	E	K	A	V	K	E	A	N	A
Template Known Secondary structure		S	T	T								T	T	T	S	S			S							T	T			G	G	G	S														S	S					S	S											S	S													T	T
Template Predicted Secondary structure
Template SS confidence
		426	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.
		465	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	E	F	L	P	L	L	P	Q	G	V	D	T	P	V	G	D	Q	A	A	R	L	S	V	G	Q	A	Q	R	V	A	V	A	R	A	L	L	N	P	C	S	L	L	L	L	D	E	P	A	A	S	L	D	A	H	S	E	Q	R	V	M	E	A	L	N	A	A	S	L	R	Q	T	T	L	M	V	T	H	Q	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	D	F	I	M	K	L	P	H	Q	F	D	T	L	V	G	E	R	G	A	Q	L	S	G	G	Q	K	Q	R	I	A	I	A	R	A	L	V	R	N	P	K	I	L	L	L	D	E	A	T	S	A	L	D	T	E	S	E	A	V	V	Q	A	A	L	D	K	A	R	E	G	R	T	T	I	V	I	A	H	R	L
Template Known Secondary structure		T	T					S	T	T	G	G	G				S	S	S	S		S	S																			S						B	T	T		S	S																T	T	S	S							S
Template Predicted Secondary structure
Template SS confidence
		506	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.
		545	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	D	L	A	D	W	D	V	I	W	V	M	Q	D	G	R	I	I	E	Q	G	R	Y	A	E	L	S	V	A	G	G	P	F	A	T	L	L	A	H	R	Q	E	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		S	T	V	R	N	A	D	V	I	A	G	F	D	G	G	V	I	V	E	Q	G	N	H	D	E	L	M	R	E	K	G	I	Y	F	K	L	V	M	T	Q	T	L	D
Template Known Secondary structure					T	T		S						S	S	S															T	S									T
Template Predicted Secondary structure
Template SS confidence
		586	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.